Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen

CLL is an incurable disease with variable prognosis. The hyper reactivity of the B-cell receptor (BCR) to unknown antigen ligation plays a pivotal role in CLL-cell survival. We aimed to investigate the BCR signalling pathway using proteomics to identify novel proteins which may have clinical relevan...

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Veröffentlicht in:	Journal of proteomics 2013-10, Vol.91, p.478-485
Hauptverfasser:	Kashuba, Elena, Eagle, Gina L., Bailey, James, Evans, Paul, Welham, Kevin J., Allsup, David, Cawkwell, Lynn
Format:	Artikel
Sprache:	eng
Schlagworte:	antigens B-cell receptor B-lymphocytes B-Lymphocytes - metabolism biomarkers Biomarkers - metabolism Cell Survival Chronic lymphocytic leukaemia gene expression regulation Gene Expression Regulation, Leukemic Humans immunoblotting Kininogen Kininogens - metabolism leukemia Leukemia, Lymphocytic, Chronic, B-Cell - immunology mass spectrometry Phosphorylation Prognosis protein synthesis proteins Proteomics Proteomics - methods Receptors, Antigen, B-Cell - metabolism Signal Transduction two-dimensional gel electrophoresis Up-Regulation
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