Ultraviolet-crosslinked hydrogel sustained-release hydrophobic antibiotics with long-term antibacterial activity and limited cytotoxicity
ABSTRACT To prolong erythromycin (EM) release and prevent the side effects of EM, a Pluronic F‐127 diacrylate macromer (PF127) was synthesized and then self‐assembled into micelles with their hydrophobic cores loaded with EM. The EM‐loaded micelles were mixed with a photoinitiator to form the EM/PF1...
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| Veröffentlicht in: | Journal of applied polymer science 2014-07, Vol.131 (13), p.np-n/a |
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| container_title | Journal of applied polymer science |
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| creator | Liu, Tao Wu, Ting Liu, Hongxi Ke, Bo Huang, Hongxing Jiang, Zhenyou Xie, Mingqiang |
| description | ABSTRACT
To prolong erythromycin (EM) release and prevent the side effects of EM, a Pluronic F‐127 diacrylate macromer (PF127) was synthesized and then self‐assembled into micelles with their hydrophobic cores loaded with EM. The EM‐loaded micelles were mixed with a photoinitiator to form the EM/PF127 hydrogels rapidly under a low‐intensity UV light. Afterward, the hydrogel properties, antibacterial performance, and cytotoxicity of this novel hybrid hydrogel were investigated. The results show that the EM/PF127 hydrogel had a rapid gelation time. The sustained release of EM reduced its side effects. With controlled antibacterial activity, the use of EM would be safer and more efficient. What is more, the EM/PF127 hydrogel showed a slight cytotoxicity, and this suggests great potential application as antibacterial hydrogels in the prevention of postoperative infection. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40438. |
| doi_str_mv | 10.1002/app.40438 |
| format | Article |
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To prolong erythromycin (EM) release and prevent the side effects of EM, a Pluronic F‐127 diacrylate macromer (PF127) was synthesized and then self‐assembled into micelles with their hydrophobic cores loaded with EM. The EM‐loaded micelles were mixed with a photoinitiator to form the EM/PF127 hydrogels rapidly under a low‐intensity UV light. Afterward, the hydrogel properties, antibacterial performance, and cytotoxicity of this novel hybrid hydrogel were investigated. The results show that the EM/PF127 hydrogel had a rapid gelation time. The sustained release of EM reduced its side effects. With controlled antibacterial activity, the use of EM would be safer and more efficient. What is more, the EM/PF127 hydrogel showed a slight cytotoxicity, and this suggests great potential application as antibacterial hydrogels in the prevention of postoperative infection. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40438.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.40438</identifier><identifier>CODEN: JAPNAB</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Applied sciences ; Biological and medical sciences ; composites ; crosslinking ; drug-delivery systems ; Exact sciences and technology ; gels ; General pharmacology ; Materials science ; Medical sciences ; Organic polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; photopolymerization ; Physicochemistry of polymers ; Polymers ; Properties and characterization ; Solution and gel properties</subject><ispartof>Journal of applied polymer science, 2014-07, Vol.131 (13), p.np-n/a</ispartof><rights>Copyright © 2014 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3988-936d60fc73c32bb86c72b79a59e658d52f9860becf6685d628c4c555ed87694b3</citedby><cites>FETCH-LOGICAL-c3988-936d60fc73c32bb86c72b79a59e658d52f9860becf6685d628c4c555ed87694b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.40438$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.40438$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28416984$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Tao</creatorcontrib><creatorcontrib>Wu, Ting</creatorcontrib><creatorcontrib>Liu, Hongxi</creatorcontrib><creatorcontrib>Ke, Bo</creatorcontrib><creatorcontrib>Huang, Hongxing</creatorcontrib><creatorcontrib>Jiang, Zhenyou</creatorcontrib><creatorcontrib>Xie, Mingqiang</creatorcontrib><title>Ultraviolet-crosslinked hydrogel sustained-release hydrophobic antibiotics with long-term antibacterial activity and limited cytotoxicity</title><title>Journal of applied polymer science</title><addtitle>J. Appl. Polym. Sci</addtitle><description>ABSTRACT
To prolong erythromycin (EM) release and prevent the side effects of EM, a Pluronic F‐127 diacrylate macromer (PF127) was synthesized and then self‐assembled into micelles with their hydrophobic cores loaded with EM. The EM‐loaded micelles were mixed with a photoinitiator to form the EM/PF127 hydrogels rapidly under a low‐intensity UV light. Afterward, the hydrogel properties, antibacterial performance, and cytotoxicity of this novel hybrid hydrogel were investigated. The results show that the EM/PF127 hydrogel had a rapid gelation time. The sustained release of EM reduced its side effects. With controlled antibacterial activity, the use of EM would be safer and more efficient. What is more, the EM/PF127 hydrogel showed a slight cytotoxicity, and this suggests great potential application as antibacterial hydrogels in the prevention of postoperative infection. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40438.</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>composites</subject><subject>crosslinking</subject><subject>drug-delivery systems</subject><subject>Exact sciences and technology</subject><subject>gels</subject><subject>General pharmacology</subject><subject>Materials science</subject><subject>Medical sciences</subject><subject>Organic polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>photopolymerization</subject><subject>Physicochemistry of polymers</subject><subject>Polymers</subject><subject>Properties and characterization</subject><subject>Solution and gel properties</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kc9OFTEUxhujiVdk4RtMYkxkMdBO_0y7RCJoQpAY0GXT6XS4B3qnY9sLzCP41hYGWZi46mm_3_lO2w-hdwTvE4ybAzNN-wwzKl-gFcGqrZlo5Eu0KhqppVL8NXqT0jXGhHAsVuj3pc_R3ELwLtc2hpQ8jDeur9ZzH8OV81XapmxgdH0dnXcmuUWa1qEDW5kxQwchg03VHeR15cN4VWcXN4tkbKnB-KoUcAt5Lsd95WEDuQyxcw453IMtwlv0ajA-ud2ndQddHn--OPpSn347-Xp0eFpbqqSsFRW9wINtqaVN10lh26ZrleHKCS573gxKCtw5OwgheV9eb5nlnLtetkKxju6gj4vvFMOvrUtZbyBZ570ZXdgmTXiDqWBMsYK-_we9Dts4ltsVijSUtq1UhdpbqMfvi27QU4SNibMmWD-Eokso-jGUwn54cjTJGj9EM1pIzw2NZEQo-TD5YOHuwLv5_4b68Pz8r3O9dEDK7v65w8QbLVracv3z7ESzsx_fySdRNvQPZxGtkw</recordid><startdate>20140705</startdate><enddate>20140705</enddate><creator>Liu, Tao</creator><creator>Wu, Ting</creator><creator>Liu, Hongxi</creator><creator>Ke, Bo</creator><creator>Huang, Hongxing</creator><creator>Jiang, Zhenyou</creator><creator>Xie, Mingqiang</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7QL</scope><scope>7T7</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20140705</creationdate><title>Ultraviolet-crosslinked hydrogel sustained-release hydrophobic antibiotics with long-term antibacterial activity and limited cytotoxicity</title><author>Liu, Tao ; Wu, Ting ; Liu, Hongxi ; Ke, Bo ; Huang, Hongxing ; Jiang, Zhenyou ; Xie, Mingqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3988-936d60fc73c32bb86c72b79a59e658d52f9860becf6685d628c4c555ed87694b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>composites</topic><topic>crosslinking</topic><topic>drug-delivery systems</topic><topic>Exact sciences and technology</topic><topic>gels</topic><topic>General pharmacology</topic><topic>Materials science</topic><topic>Medical sciences</topic><topic>Organic polymers</topic><topic>Pharmaceutical technology. 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Drug treatments</topic><topic>photopolymerization</topic><topic>Physicochemistry of polymers</topic><topic>Polymers</topic><topic>Properties and characterization</topic><topic>Solution and gel properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Tao</creatorcontrib><creatorcontrib>Wu, Ting</creatorcontrib><creatorcontrib>Liu, Hongxi</creatorcontrib><creatorcontrib>Ke, Bo</creatorcontrib><creatorcontrib>Huang, Hongxing</creatorcontrib><creatorcontrib>Jiang, Zhenyou</creatorcontrib><creatorcontrib>Xie, Mingqiang</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Tao</au><au>Wu, Ting</au><au>Liu, Hongxi</au><au>Ke, Bo</au><au>Huang, Hongxing</au><au>Jiang, Zhenyou</au><au>Xie, Mingqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultraviolet-crosslinked hydrogel sustained-release hydrophobic antibiotics with long-term antibacterial activity and limited cytotoxicity</atitle><jtitle>Journal of applied polymer science</jtitle><addtitle>J. Appl. Polym. Sci</addtitle><date>2014-07-05</date><risdate>2014</risdate><volume>131</volume><issue>13</issue><spage>np</spage><epage>n/a</epage><pages>np-n/a</pages><issn>0021-8995</issn><eissn>1097-4628</eissn><coden>JAPNAB</coden><abstract>ABSTRACT
To prolong erythromycin (EM) release and prevent the side effects of EM, a Pluronic F‐127 diacrylate macromer (PF127) was synthesized and then self‐assembled into micelles with their hydrophobic cores loaded with EM. The EM‐loaded micelles were mixed with a photoinitiator to form the EM/PF127 hydrogels rapidly under a low‐intensity UV light. Afterward, the hydrogel properties, antibacterial performance, and cytotoxicity of this novel hybrid hydrogel were investigated. The results show that the EM/PF127 hydrogel had a rapid gelation time. The sustained release of EM reduced its side effects. With controlled antibacterial activity, the use of EM would be safer and more efficient. What is more, the EM/PF127 hydrogel showed a slight cytotoxicity, and this suggests great potential application as antibacterial hydrogels in the prevention of postoperative infection. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40438.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1002/app.40438</doi><tpages>8</tpages></addata></record> |
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| subjects | Applied sciences Biological and medical sciences composites crosslinking drug-delivery systems Exact sciences and technology gels General pharmacology Materials science Medical sciences Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments photopolymerization Physicochemistry of polymers Polymers Properties and characterization Solution and gel properties |
| title | Ultraviolet-crosslinked hydrogel sustained-release hydrophobic antibiotics with long-term antibacterial activity and limited cytotoxicity |
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