Design, synthesis, anti-schistosomal activity and molecular docking of novel 8-hydroxyquinoline-5-sufonyl 1,4-diazepine derivatives

[Display omitted] ► Novel 8-hydroxyquinoline-5-sufonyl 1,4-diazepine derivatives were synthesized. ► Their in vitro anti-schistosomal activity were reported. ► Compound 7b showed the highest anti-schistosomal activity. ► The most active compounds underwent molecular docking against TGR. ► Compound 7...

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Veröffentlicht in:	Bioorganic chemistry 2013-02, Vol.46, p.17-25
Hauptverfasser:	Eweas, Ahmad F., Allam, Gamal, Abuelsaad, Abdelaziz S.A., ALGhamdi, Abdul Hamid, Maghrabi, Ibrahim A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Diazepines 8-Hydroxyquinoline Animals Anti-schistosoma Azepines - chemical synthesis Azepines - chemistry Azepines - pharmacology Drug Design Glutathione Reductase - antagonists & inhibitors Glutathione Reductase - chemistry Glutathione Reductase - metabolism Humans Hydroxyquinolines - chemical synthesis Hydroxyquinolines - chemistry Hydroxyquinolines - pharmacology Models, Molecular Molecular docking Molecular Docking Simulation Schistosoma Schistosoma - drug effects Schistosoma - enzymology Schistosoma - physiology Schistosomiasis - drug therapy Schistosomiasis - parasitology Schistosomicides - chemical synthesis Schistosomicides - chemistry Schistosomicides - pharmacology Thioredoxin-Disulfide Reductase - antagonists & inhibitors Thioredoxin-Disulfide Reductase - chemistry Thioredoxin-Disulfide Reductase - metabolism Thioredoxin-glutatione reductase (TGR)
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