Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development

Recurrent depressive disorder (rDD) is a multifactorial disease. Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressiv...

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Veröffentlicht in:Progress in neuro-psychopharmacology & biological psychiatry 2013-08, Vol.45, p.117-124
Hauptverfasser: Gałecki, Piotr, Gałecka, Elżbieta, Maes, Michael, Orzechowska, Agata, Berent, Dominika, Talarowska, Monika, Bobińska, Kinga, Lewiński, Andrzej, Bieńkiewicz, Małgorzata, Szemraj, Janusz
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container_title Progress in neuro-psychopharmacology & biological psychiatry
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creator Gałecki, Piotr
Gałecka, Elżbieta
Maes, Michael
Orzechowska, Agata
Berent, Dominika
Talarowska, Monika
Bobińska, Kinga
Lewiński, Andrzej
Bieńkiewicz, Małgorzata
Szemraj, Janusz
description Recurrent depressive disorder (rDD) is a multifactorial disease. Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available. The aim of the study was to analyze the association between VEGFA gene polymorphisms (+405G/C; rs2010963, +936C/T; rs 3025039), VEGFA gene expression, and its serum protein levels in rDD in the Caucasian population. In the current study, 268 patients and 200 healthy controls of the Caucasian origin were involved. Genotyping and gene expression were performed using polymerase chain reaction (PCR)-based methods. Enzyme-linked immunosorbent assay (ELISA) was used for detection of circulating serum VEGF levels. The distribution of VEGFA polymorphism +405G/C differed significantly between rDD patients and healthy subjects. The results of this study indicated that the C allele and CC genotype of VEGFA are risk factors for rDD. Haplotypes CC and TG are the important factors for depression development. Further, VEGFA mRNA expression and VEGF levels were higher in rDD patients than in controls. The VEGFA gene polymorphism may serve as a prognostic factor for rDD development. Our study showed higher levels of both VEGFA mRNA in the peripheral blood cells and serum VEGF in patients diagnosed with rDD than in healthy controls. The obtained results suggest VEGF and the gene encoding the molecule play a role in the etiology of the disease and should be further investigated. •VEGF levels are increased in recurrent depression.•Genetic variant of VEGFA determines risk of recurrent depression.•VEGFA is one of the factors involved in etiology of depression.
doi_str_mv 10.1016/j.pnpbp.2013.04.011
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Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available. The aim of the study was to analyze the association between VEGFA gene polymorphisms (+405G/C; rs2010963, +936C/T; rs 3025039), VEGFA gene expression, and its serum protein levels in rDD in the Caucasian population. In the current study, 268 patients and 200 healthy controls of the Caucasian origin were involved. Genotyping and gene expression were performed using polymerase chain reaction (PCR)-based methods. Enzyme-linked immunosorbent assay (ELISA) was used for detection of circulating serum VEGF levels. The distribution of VEGFA polymorphism +405G/C differed significantly between rDD patients and healthy subjects. The results of this study indicated that the C allele and CC genotype of VEGFA are risk factors for rDD. Haplotypes CC and TG are the important factors for depression development. Further, VEGFA mRNA expression and VEGF levels were higher in rDD patients than in controls. The VEGFA gene polymorphism may serve as a prognostic factor for rDD development. Our study showed higher levels of both VEGFA mRNA in the peripheral blood cells and serum VEGF in patients diagnosed with rDD than in healthy controls. 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Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available. The aim of the study was to analyze the association between VEGFA gene polymorphisms (+405G/C; rs2010963, +936C/T; rs 3025039), VEGFA gene expression, and its serum protein levels in rDD in the Caucasian population. In the current study, 268 patients and 200 healthy controls of the Caucasian origin were involved. Genotyping and gene expression were performed using polymerase chain reaction (PCR)-based methods. Enzyme-linked immunosorbent assay (ELISA) was used for detection of circulating serum VEGF levels. The distribution of VEGFA polymorphism +405G/C differed significantly between rDD patients and healthy subjects. The results of this study indicated that the C allele and CC genotype of VEGFA are risk factors for rDD. Haplotypes CC and TG are the important factors for depression development. Further, VEGFA mRNA expression and VEGF levels were higher in rDD patients than in controls. The VEGFA gene polymorphism may serve as a prognostic factor for rDD development. Our study showed higher levels of both VEGFA mRNA in the peripheral blood cells and serum VEGF in patients diagnosed with rDD than in healthy controls. 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Psychiatry</topic><topic>Recurrence</topic><topic>Recurrent depressive disorder</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>VEGF levels inflammation</topic><topic>VEGFA gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gałecki, Piotr</creatorcontrib><creatorcontrib>Gałecka, Elżbieta</creatorcontrib><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>Orzechowska, Agata</creatorcontrib><creatorcontrib>Berent, Dominika</creatorcontrib><creatorcontrib>Talarowska, Monika</creatorcontrib><creatorcontrib>Bobińska, Kinga</creatorcontrib><creatorcontrib>Lewiński, Andrzej</creatorcontrib><creatorcontrib>Bieńkiewicz, Małgorzata</creatorcontrib><creatorcontrib>Szemraj, Janusz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Progress in neuro-psychopharmacology &amp; biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gałecki, Piotr</au><au>Gałecka, Elżbieta</au><au>Maes, Michael</au><au>Orzechowska, Agata</au><au>Berent, Dominika</au><au>Talarowska, Monika</au><au>Bobińska, Kinga</au><au>Lewiński, Andrzej</au><au>Bieńkiewicz, Małgorzata</au><au>Szemraj, Janusz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development</atitle><jtitle>Progress in neuro-psychopharmacology &amp; biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>45</volume><spage>117</spage><epage>124</epage><pages>117-124</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Recurrent depressive disorder (rDD) is a multifactorial disease. Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available. The aim of the study was to analyze the association between VEGFA gene polymorphisms (+405G/C; rs2010963, +936C/T; rs 3025039), VEGFA gene expression, and its serum protein levels in rDD in the Caucasian population. In the current study, 268 patients and 200 healthy controls of the Caucasian origin were involved. Genotyping and gene expression were performed using polymerase chain reaction (PCR)-based methods. Enzyme-linked immunosorbent assay (ELISA) was used for detection of circulating serum VEGF levels. The distribution of VEGFA polymorphism +405G/C differed significantly between rDD patients and healthy subjects. The results of this study indicated that the C allele and CC genotype of VEGFA are risk factors for rDD. Haplotypes CC and TG are the important factors for depression development. Further, VEGFA mRNA expression and VEGF levels were higher in rDD patients than in controls. The VEGFA gene polymorphism may serve as a prognostic factor for rDD development. Our study showed higher levels of both VEGFA mRNA in the peripheral blood cells and serum VEGF in patients diagnosed with rDD than in healthy controls. The obtained results suggest VEGF and the gene encoding the molecule play a role in the etiology of the disease and should be further investigated. •VEGF levels are increased in recurrent depression.•Genetic variant of VEGFA determines risk of recurrent depression.•VEGFA is one of the factors involved in etiology of depression.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>23673188</pmid><doi>10.1016/j.pnpbp.2013.04.011</doi><tpages>8</tpages></addata></record>
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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Adult
Adult and adolescent clinical studies
Biological and medical sciences
Case-Control Studies
Caucasian population
Depression
Depressive Disorder - genetics
European Continental Ancestry Group - genetics
Female
Gene Expression - genetics
Genetic Predisposition to Disease - genetics
Haplotypes
Haplotypes - genetics
Humans
Male
Medical sciences
Middle Aged
Mood disorders
Neuropharmacology
Peripheral blood
Pharmacology. Drug treatments
Polymorphism, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Recurrence
Recurrent depressive disorder
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor A - genetics
VEGF levels inflammation
VEGFA gene
title Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development
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