Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development
Recurrent depressive disorder (rDD) is a multifactorial disease. Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressiv...
Gespeichert in:
Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2013-08, Vol.45, p.117-124 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 124 |
---|---|
container_issue | |
container_start_page | 117 |
container_title | Progress in neuro-psychopharmacology & biological psychiatry |
container_volume | 45 |
creator | Gałecki, Piotr Gałecka, Elżbieta Maes, Michael Orzechowska, Agata Berent, Dominika Talarowska, Monika Bobińska, Kinga Lewiński, Andrzej Bieńkiewicz, Małgorzata Szemraj, Janusz |
description | Recurrent depressive disorder (rDD) is a multifactorial disease. Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available. The aim of the study was to analyze the association between VEGFA gene polymorphisms (+405G/C; rs2010963, +936C/T; rs 3025039), VEGFA gene expression, and its serum protein levels in rDD in the Caucasian population.
In the current study, 268 patients and 200 healthy controls of the Caucasian origin were involved. Genotyping and gene expression were performed using polymerase chain reaction (PCR)-based methods. Enzyme-linked immunosorbent assay (ELISA) was used for detection of circulating serum VEGF levels.
The distribution of VEGFA polymorphism +405G/C differed significantly between rDD patients and healthy subjects. The results of this study indicated that the C allele and CC genotype of VEGFA are risk factors for rDD. Haplotypes CC and TG are the important factors for depression development. Further, VEGFA mRNA expression and VEGF levels were higher in rDD patients than in controls.
The VEGFA gene polymorphism may serve as a prognostic factor for rDD development. Our study showed higher levels of both VEGFA mRNA in the peripheral blood cells and serum VEGF in patients diagnosed with rDD than in healthy controls. The obtained results suggest VEGF and the gene encoding the molecule play a role in the etiology of the disease and should be further investigated.
•VEGF levels are increased in recurrent depression.•Genetic variant of VEGFA determines risk of recurrent depression.•VEGFA is one of the factors involved in etiology of depression. |
doi_str_mv | 10.1016/j.pnpbp.2013.04.011 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1520361444</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0278584613000778</els_id><sourcerecordid>1412156739</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-bc41e03cb8bd48d96c3795a33f66f336cfe948cdeefc4935b4176e5f3d6c208e3</originalsourceid><addsrcrecordid>eNqFkc9u1DAQhyMEokvhCZCQL0jlsMGOHcc5cKiq_kGqxAV6tRx7vOtVEgdPsmifgZfGZbdwg5Mtz_fzjOYrireMlowy-XFXTuPUTWVFGS-pKCljz4oVU41ai4rJ58WKVvleKyHPileIO0ozSfnL4qzisuFMqVXx88GgXXqTCIwuzlvog-nJJsUf85Z4Y-eYyAZGIBcP17c3lx_IFPvDENO0DTggGcyBIKQ9EINkSnEzRpyDPSWR-BxPYJeUYJyJgykBYsi4CxiTg5Tf9tDHacj118ULb3qEN6fzvPh2c_316m59_-X289Xl_doKpeZ1ZwUDym2nOieUa6XlTVsbzr2UnnNpPbRCWQfgrWh53QnWSKg9d9JWVAE_Ly6O_-aBvy-Asx4CWuh7M0JcULO6olwyIcT_UcEqVudlthnlR9SmiJjA6ymFwaSDZlQ_CtM7_VuYfhSmqdBZWE69OzVYugHcn8yToQy8PwFZlOl9MqMN-JdrJG1bSTP36chB3tw-QNJoA4wWXMgCZu1i-OcgvwBo_bga</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1412156739</pqid></control><display><type>article</type><title>Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Gałecki, Piotr ; Gałecka, Elżbieta ; Maes, Michael ; Orzechowska, Agata ; Berent, Dominika ; Talarowska, Monika ; Bobińska, Kinga ; Lewiński, Andrzej ; Bieńkiewicz, Małgorzata ; Szemraj, Janusz</creator><creatorcontrib>Gałecki, Piotr ; Gałecka, Elżbieta ; Maes, Michael ; Orzechowska, Agata ; Berent, Dominika ; Talarowska, Monika ; Bobińska, Kinga ; Lewiński, Andrzej ; Bieńkiewicz, Małgorzata ; Szemraj, Janusz</creatorcontrib><description>Recurrent depressive disorder (rDD) is a multifactorial disease. Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available. The aim of the study was to analyze the association between VEGFA gene polymorphisms (+405G/C; rs2010963, +936C/T; rs 3025039), VEGFA gene expression, and its serum protein levels in rDD in the Caucasian population.
In the current study, 268 patients and 200 healthy controls of the Caucasian origin were involved. Genotyping and gene expression were performed using polymerase chain reaction (PCR)-based methods. Enzyme-linked immunosorbent assay (ELISA) was used for detection of circulating serum VEGF levels.
The distribution of VEGFA polymorphism +405G/C differed significantly between rDD patients and healthy subjects. The results of this study indicated that the C allele and CC genotype of VEGFA are risk factors for rDD. Haplotypes CC and TG are the important factors for depression development. Further, VEGFA mRNA expression and VEGF levels were higher in rDD patients than in controls.
The VEGFA gene polymorphism may serve as a prognostic factor for rDD development. Our study showed higher levels of both VEGFA mRNA in the peripheral blood cells and serum VEGF in patients diagnosed with rDD than in healthy controls. The obtained results suggest VEGF and the gene encoding the molecule play a role in the etiology of the disease and should be further investigated.
•VEGF levels are increased in recurrent depression.•Genetic variant of VEGFA determines risk of recurrent depression.•VEGFA is one of the factors involved in etiology of depression.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2013.04.011</identifier><identifier>PMID: 23673188</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Case-Control Studies ; Caucasian population ; Depression ; Depressive Disorder - genetics ; European Continental Ancestry Group - genetics ; Female ; Gene Expression - genetics ; Genetic Predisposition to Disease - genetics ; Haplotypes ; Haplotypes - genetics ; Humans ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Neuropharmacology ; Peripheral blood ; Pharmacology. Drug treatments ; Polymorphism, Genetic - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Recurrence ; Recurrent depressive disorder ; Vascular Endothelial Growth Factor A - blood ; Vascular Endothelial Growth Factor A - genetics ; VEGF levels inflammation ; VEGFA gene</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2013-08, Vol.45, p.117-124</ispartof><rights>2013 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-bc41e03cb8bd48d96c3795a33f66f336cfe948cdeefc4935b4176e5f3d6c208e3</citedby><cites>FETCH-LOGICAL-c488t-bc41e03cb8bd48d96c3795a33f66f336cfe948cdeefc4935b4176e5f3d6c208e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2013.04.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27609960$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23673188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gałecki, Piotr</creatorcontrib><creatorcontrib>Gałecka, Elżbieta</creatorcontrib><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>Orzechowska, Agata</creatorcontrib><creatorcontrib>Berent, Dominika</creatorcontrib><creatorcontrib>Talarowska, Monika</creatorcontrib><creatorcontrib>Bobińska, Kinga</creatorcontrib><creatorcontrib>Lewiński, Andrzej</creatorcontrib><creatorcontrib>Bieńkiewicz, Małgorzata</creatorcontrib><creatorcontrib>Szemraj, Janusz</creatorcontrib><title>Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Recurrent depressive disorder (rDD) is a multifactorial disease. Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available. The aim of the study was to analyze the association between VEGFA gene polymorphisms (+405G/C; rs2010963, +936C/T; rs 3025039), VEGFA gene expression, and its serum protein levels in rDD in the Caucasian population.
In the current study, 268 patients and 200 healthy controls of the Caucasian origin were involved. Genotyping and gene expression were performed using polymerase chain reaction (PCR)-based methods. Enzyme-linked immunosorbent assay (ELISA) was used for detection of circulating serum VEGF levels.
The distribution of VEGFA polymorphism +405G/C differed significantly between rDD patients and healthy subjects. The results of this study indicated that the C allele and CC genotype of VEGFA are risk factors for rDD. Haplotypes CC and TG are the important factors for depression development. Further, VEGFA mRNA expression and VEGF levels were higher in rDD patients than in controls.
The VEGFA gene polymorphism may serve as a prognostic factor for rDD development. Our study showed higher levels of both VEGFA mRNA in the peripheral blood cells and serum VEGF in patients diagnosed with rDD than in healthy controls. The obtained results suggest VEGF and the gene encoding the molecule play a role in the etiology of the disease and should be further investigated.
•VEGF levels are increased in recurrent depression.•Genetic variant of VEGFA determines risk of recurrent depression.•VEGFA is one of the factors involved in etiology of depression.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Caucasian population</subject><subject>Depression</subject><subject>Depressive Disorder - genetics</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Gene Expression - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Neuropharmacology</subject><subject>Peripheral blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Recurrence</subject><subject>Recurrent depressive disorder</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>VEGF levels inflammation</subject><subject>VEGFA gene</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhyMEokvhCZCQL0jlsMGOHcc5cKiq_kGqxAV6tRx7vOtVEgdPsmifgZfGZbdwg5Mtz_fzjOYrireMlowy-XFXTuPUTWVFGS-pKCljz4oVU41ai4rJ58WKVvleKyHPileIO0ozSfnL4qzisuFMqVXx88GgXXqTCIwuzlvog-nJJsUf85Z4Y-eYyAZGIBcP17c3lx_IFPvDENO0DTggGcyBIKQ9EINkSnEzRpyDPSWR-BxPYJeUYJyJgykBYsi4CxiTg5Tf9tDHacj118ULb3qEN6fzvPh2c_316m59_-X289Xl_doKpeZ1ZwUDym2nOieUa6XlTVsbzr2UnnNpPbRCWQfgrWh53QnWSKg9d9JWVAE_Ly6O_-aBvy-Asx4CWuh7M0JcULO6olwyIcT_UcEqVudlthnlR9SmiJjA6ymFwaSDZlQ_CtM7_VuYfhSmqdBZWE69OzVYugHcn8yToQy8PwFZlOl9MqMN-JdrJG1bSTP36chB3tw-QNJoA4wWXMgCZu1i-OcgvwBo_bga</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Gałecki, Piotr</creator><creator>Gałecka, Elżbieta</creator><creator>Maes, Michael</creator><creator>Orzechowska, Agata</creator><creator>Berent, Dominika</creator><creator>Talarowska, Monika</creator><creator>Bobińska, Kinga</creator><creator>Lewiński, Andrzej</creator><creator>Bieńkiewicz, Małgorzata</creator><creator>Szemraj, Janusz</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130801</creationdate><title>Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development</title><author>Gałecki, Piotr ; Gałecka, Elżbieta ; Maes, Michael ; Orzechowska, Agata ; Berent, Dominika ; Talarowska, Monika ; Bobińska, Kinga ; Lewiński, Andrzej ; Bieńkiewicz, Małgorzata ; Szemraj, Janusz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-bc41e03cb8bd48d96c3795a33f66f336cfe948cdeefc4935b4176e5f3d6c208e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Caucasian population</topic><topic>Depression</topic><topic>Depressive Disorder - genetics</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Gene Expression - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Haplotypes</topic><topic>Haplotypes - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Neuropharmacology</topic><topic>Peripheral blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Recurrence</topic><topic>Recurrent depressive disorder</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>VEGF levels inflammation</topic><topic>VEGFA gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gałecki, Piotr</creatorcontrib><creatorcontrib>Gałecka, Elżbieta</creatorcontrib><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>Orzechowska, Agata</creatorcontrib><creatorcontrib>Berent, Dominika</creatorcontrib><creatorcontrib>Talarowska, Monika</creatorcontrib><creatorcontrib>Bobińska, Kinga</creatorcontrib><creatorcontrib>Lewiński, Andrzej</creatorcontrib><creatorcontrib>Bieńkiewicz, Małgorzata</creatorcontrib><creatorcontrib>Szemraj, Janusz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gałecki, Piotr</au><au>Gałecka, Elżbieta</au><au>Maes, Michael</au><au>Orzechowska, Agata</au><au>Berent, Dominika</au><au>Talarowska, Monika</au><au>Bobińska, Kinga</au><au>Lewiński, Andrzej</au><au>Bieńkiewicz, Małgorzata</au><au>Szemraj, Janusz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>45</volume><spage>117</spage><epage>124</epage><pages>117-124</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Recurrent depressive disorder (rDD) is a multifactorial disease. Vascular endothelial growth factor (VEGF) is one of the factors that have been suggested to play a role in the etiology and/or development of this disease. Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available. The aim of the study was to analyze the association between VEGFA gene polymorphisms (+405G/C; rs2010963, +936C/T; rs 3025039), VEGFA gene expression, and its serum protein levels in rDD in the Caucasian population.
In the current study, 268 patients and 200 healthy controls of the Caucasian origin were involved. Genotyping and gene expression were performed using polymerase chain reaction (PCR)-based methods. Enzyme-linked immunosorbent assay (ELISA) was used for detection of circulating serum VEGF levels.
The distribution of VEGFA polymorphism +405G/C differed significantly between rDD patients and healthy subjects. The results of this study indicated that the C allele and CC genotype of VEGFA are risk factors for rDD. Haplotypes CC and TG are the important factors for depression development. Further, VEGFA mRNA expression and VEGF levels were higher in rDD patients than in controls.
The VEGFA gene polymorphism may serve as a prognostic factor for rDD development. Our study showed higher levels of both VEGFA mRNA in the peripheral blood cells and serum VEGF in patients diagnosed with rDD than in healthy controls. The obtained results suggest VEGF and the gene encoding the molecule play a role in the etiology of the disease and should be further investigated.
•VEGF levels are increased in recurrent depression.•Genetic variant of VEGFA determines risk of recurrent depression.•VEGFA is one of the factors involved in etiology of depression.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>23673188</pmid><doi>10.1016/j.pnpbp.2013.04.011</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0278-5846 |
ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 2013-08, Vol.45, p.117-124 |
issn | 0278-5846 1878-4216 |
language | eng |
recordid | cdi_proquest_miscellaneous_1520361444 |
source | MEDLINE; Access via ScienceDirect (Elsevier) |
subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Case-Control Studies Caucasian population Depression Depressive Disorder - genetics European Continental Ancestry Group - genetics Female Gene Expression - genetics Genetic Predisposition to Disease - genetics Haplotypes Haplotypes - genetics Humans Male Medical sciences Middle Aged Mood disorders Neuropharmacology Peripheral blood Pharmacology. Drug treatments Polymorphism, Genetic - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Recurrence Recurrent depressive disorder Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - genetics VEGF levels inflammation VEGFA gene |
title | Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-06T02%3A34%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vascular%20endothelial%20growth%20factor%20gene%20(VEGFA)%20polymorphisms%20may%20serve%20as%20prognostic%20factors%20for%20recurrent%20depressive%20disorder%20development&rft.jtitle=Progress%20in%20neuro-psychopharmacology%20&%20biological%20psychiatry&rft.au=Ga%C5%82ecki,%20Piotr&rft.date=2013-08-01&rft.volume=45&rft.spage=117&rft.epage=124&rft.pages=117-124&rft.issn=0278-5846&rft.eissn=1878-4216&rft.coden=PNPPD7&rft_id=info:doi/10.1016/j.pnpbp.2013.04.011&rft_dat=%3Cproquest_cross%3E1412156739%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1412156739&rft_id=info:pmid/23673188&rft_els_id=S0278584613000778&rfr_iscdi=true |