Gastrectomy for stage IV gastric cancer. a systematic review and meta-analysis
Gastrectomy as a primary treatment for patients with metastatic gastric cancer (M1) is highly controversial. Herein, a review of the literature was undertaken with the aim of assessing evidence regarding associated morbidity and mortality, overall survival, palliation and quality of life. A systemat...
Gespeichert in:
| Veröffentlicht in: | Anticancer research 2014-05, Vol.34 (5), p.2079-2085 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2085 |
|---|---|
| container_issue | 5 |
| container_start_page | 2079 |
| container_title | Anticancer research |
| container_volume | 34 |
| creator | Lasithiotakis, Konstantinos Antoniou, Stavros A Antoniou, George A Kaklamanos, Ioannis Zoras, Odysseas |
| description | Gastrectomy as a primary treatment for patients with metastatic gastric cancer (M1) is highly controversial. Herein, a review of the literature was undertaken with the aim of assessing evidence regarding associated morbidity and mortality, overall survival, palliation and quality of life.
A systematic review of the literature from 1980 to 2013 was undertaken to identify relevant studies. Outcome data were pooled, and combined overall effect sizes were calculated using fixed or random effects models. The search identified 19 non-randomized studies reporting on 2,911 patients.
Overall postoperative mortality and morbidity were 14% and 27% and were higher in Western than in Asian patients. In studies published during the past decade postoperative mortality was less than 5%. The weighted 1- and 2-year overall survival rates were 38% and 17%, and were twice as high in Asian versus Western patients. In the meta-analysis, the 1-year overall survival was significantly higher in patients undergoing gastrectomy versus conservative (odds ratio (OR)=4.9, 95% confidence interval (CI)=3.2 to 7.5, p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1520109249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1520109249</sourcerecordid><originalsourceid>FETCH-LOGICAL-p211t-d47b0526ad27b9912ea2418c9f3c6aef3ce04c33382dbc9801296f4531bc80c03</originalsourceid><addsrcrecordid>eNo1kE1LxDAYhIMg7rr6FyRHL5V8tUmOsui6sOhFvZa36dul0rQ1SZX-eyuulxmYeZjDnJE115ZnOpdsRS5j_GCsKKyRF2QllNaGMbsmzzuIKaBLg59pMwQaExyR7t_p8bdoHXXQOwx3FGicY0IPaQkDfrX4TaGvqccEGfTQzbGNV-S8gS7i9ck35O3x4XX7lB1edvvt_SEbBecpq5WuWC4KqIWurOUCQShunG2kKwAXRaaclNKIunLWMC5s0ahc8soZ5pjckNu_3TEMnxPGVPo2Ouw66HGYYslzwTizQtkFvTmhU-WxLsfQeghz-f-B_AFs0Vau</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1520109249</pqid></control><display><type>article</type><title>Gastrectomy for stage IV gastric cancer. a systematic review and meta-analysis</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Lasithiotakis, Konstantinos ; Antoniou, Stavros A ; Antoniou, George A ; Kaklamanos, Ioannis ; Zoras, Odysseas</creator><creatorcontrib>Lasithiotakis, Konstantinos ; Antoniou, Stavros A ; Antoniou, George A ; Kaklamanos, Ioannis ; Zoras, Odysseas</creatorcontrib><description>Gastrectomy as a primary treatment for patients with metastatic gastric cancer (M1) is highly controversial. Herein, a review of the literature was undertaken with the aim of assessing evidence regarding associated morbidity and mortality, overall survival, palliation and quality of life.
A systematic review of the literature from 1980 to 2013 was undertaken to identify relevant studies. Outcome data were pooled, and combined overall effect sizes were calculated using fixed or random effects models. The search identified 19 non-randomized studies reporting on 2,911 patients.
Overall postoperative mortality and morbidity were 14% and 27% and were higher in Western than in Asian patients. In studies published during the past decade postoperative mortality was less than 5%. The weighted 1- and 2-year overall survival rates were 38% and 17%, and were twice as high in Asian versus Western patients. In the meta-analysis, the 1-year overall survival was significantly higher in patients undergoing gastrectomy versus conservative (odds ratio (OR)=4.9, 95% confidence interval (CI)=3.2 to 7.5, p<0.0001) or gastrectomy versus non-resectional treatment (OR=2.6, 95% CI=1.7 to 4.3, p<0.0001). Studies reporting on quality of life and palliation indicate a possible benefit of such palliative gastrectomy.
A possible benefit of gastrectomy compared to non-resectional treatment for stage IV gastric cancer in terms of survival and palliation was evident but has to be cautiously interpreted due to potential sources of bias of retrospective non-randomized studies. Several questions regarding the optimal management of these patients remain unanswered and require a properly-designed randomized trial.</description><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 24778009</identifier><language>eng</language><publisher>Greece</publisher><subject>Gastrectomy - mortality ; Humans ; Neoplasm Staging ; Palliative Care - methods ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Treatment Outcome</subject><ispartof>Anticancer research, 2014-05, Vol.34 (5), p.2079-2085</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24778009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lasithiotakis, Konstantinos</creatorcontrib><creatorcontrib>Antoniou, Stavros A</creatorcontrib><creatorcontrib>Antoniou, George A</creatorcontrib><creatorcontrib>Kaklamanos, Ioannis</creatorcontrib><creatorcontrib>Zoras, Odysseas</creatorcontrib><title>Gastrectomy for stage IV gastric cancer. a systematic review and meta-analysis</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Gastrectomy as a primary treatment for patients with metastatic gastric cancer (M1) is highly controversial. Herein, a review of the literature was undertaken with the aim of assessing evidence regarding associated morbidity and mortality, overall survival, palliation and quality of life.
A systematic review of the literature from 1980 to 2013 was undertaken to identify relevant studies. Outcome data were pooled, and combined overall effect sizes were calculated using fixed or random effects models. The search identified 19 non-randomized studies reporting on 2,911 patients.
Overall postoperative mortality and morbidity were 14% and 27% and were higher in Western than in Asian patients. In studies published during the past decade postoperative mortality was less than 5%. The weighted 1- and 2-year overall survival rates were 38% and 17%, and were twice as high in Asian versus Western patients. In the meta-analysis, the 1-year overall survival was significantly higher in patients undergoing gastrectomy versus conservative (odds ratio (OR)=4.9, 95% confidence interval (CI)=3.2 to 7.5, p<0.0001) or gastrectomy versus non-resectional treatment (OR=2.6, 95% CI=1.7 to 4.3, p<0.0001). Studies reporting on quality of life and palliation indicate a possible benefit of such palliative gastrectomy.
A possible benefit of gastrectomy compared to non-resectional treatment for stage IV gastric cancer in terms of survival and palliation was evident but has to be cautiously interpreted due to potential sources of bias of retrospective non-randomized studies. Several questions regarding the optimal management of these patients remain unanswered and require a properly-designed randomized trial.</description><subject>Gastrectomy - mortality</subject><subject>Humans</subject><subject>Neoplasm Staging</subject><subject>Palliative Care - methods</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Treatment Outcome</subject><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LxDAYhIMg7rr6FyRHL5V8tUmOsui6sOhFvZa36dul0rQ1SZX-eyuulxmYeZjDnJE115ZnOpdsRS5j_GCsKKyRF2QllNaGMbsmzzuIKaBLg59pMwQaExyR7t_p8bdoHXXQOwx3FGicY0IPaQkDfrX4TaGvqccEGfTQzbGNV-S8gS7i9ck35O3x4XX7lB1edvvt_SEbBecpq5WuWC4KqIWurOUCQShunG2kKwAXRaaclNKIunLWMC5s0ahc8soZ5pjckNu_3TEMnxPGVPo2Ouw66HGYYslzwTizQtkFvTmhU-WxLsfQeghz-f-B_AFs0Vau</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Lasithiotakis, Konstantinos</creator><creator>Antoniou, Stavros A</creator><creator>Antoniou, George A</creator><creator>Kaklamanos, Ioannis</creator><creator>Zoras, Odysseas</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>Gastrectomy for stage IV gastric cancer. a systematic review and meta-analysis</title><author>Lasithiotakis, Konstantinos ; Antoniou, Stavros A ; Antoniou, George A ; Kaklamanos, Ioannis ; Zoras, Odysseas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-d47b0526ad27b9912ea2418c9f3c6aef3ce04c33382dbc9801296f4531bc80c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Gastrectomy - mortality</topic><topic>Humans</topic><topic>Neoplasm Staging</topic><topic>Palliative Care - methods</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lasithiotakis, Konstantinos</creatorcontrib><creatorcontrib>Antoniou, Stavros A</creatorcontrib><creatorcontrib>Antoniou, George A</creatorcontrib><creatorcontrib>Kaklamanos, Ioannis</creatorcontrib><creatorcontrib>Zoras, Odysseas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lasithiotakis, Konstantinos</au><au>Antoniou, Stavros A</au><au>Antoniou, George A</au><au>Kaklamanos, Ioannis</au><au>Zoras, Odysseas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastrectomy for stage IV gastric cancer. a systematic review and meta-analysis</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2014-05</date><risdate>2014</risdate><volume>34</volume><issue>5</issue><spage>2079</spage><epage>2085</epage><pages>2079-2085</pages><eissn>1791-7530</eissn><abstract>Gastrectomy as a primary treatment for patients with metastatic gastric cancer (M1) is highly controversial. Herein, a review of the literature was undertaken with the aim of assessing evidence regarding associated morbidity and mortality, overall survival, palliation and quality of life.
A systematic review of the literature from 1980 to 2013 was undertaken to identify relevant studies. Outcome data were pooled, and combined overall effect sizes were calculated using fixed or random effects models. The search identified 19 non-randomized studies reporting on 2,911 patients.
Overall postoperative mortality and morbidity were 14% and 27% and were higher in Western than in Asian patients. In studies published during the past decade postoperative mortality was less than 5%. The weighted 1- and 2-year overall survival rates were 38% and 17%, and were twice as high in Asian versus Western patients. In the meta-analysis, the 1-year overall survival was significantly higher in patients undergoing gastrectomy versus conservative (odds ratio (OR)=4.9, 95% confidence interval (CI)=3.2 to 7.5, p<0.0001) or gastrectomy versus non-resectional treatment (OR=2.6, 95% CI=1.7 to 4.3, p<0.0001). Studies reporting on quality of life and palliation indicate a possible benefit of such palliative gastrectomy.
A possible benefit of gastrectomy compared to non-resectional treatment for stage IV gastric cancer in terms of survival and palliation was evident but has to be cautiously interpreted due to potential sources of bias of retrospective non-randomized studies. Several questions regarding the optimal management of these patients remain unanswered and require a properly-designed randomized trial.</abstract><cop>Greece</cop><pmid>24778009</pmid><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1791-7530 |
| ispartof | Anticancer research, 2014-05, Vol.34 (5), p.2079-2085 |
| issn | 1791-7530 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1520109249 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Gastrectomy - mortality Humans Neoplasm Staging Palliative Care - methods Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Treatment Outcome |
| title | Gastrectomy for stage IV gastric cancer. a systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T23%3A59%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gastrectomy%20for%20stage%20IV%20gastric%20cancer.%20a%20systematic%20review%20and%20meta-analysis&rft.jtitle=Anticancer%20research&rft.au=Lasithiotakis,%20Konstantinos&rft.date=2014-05&rft.volume=34&rft.issue=5&rft.spage=2079&rft.epage=2085&rft.pages=2079-2085&rft.eissn=1791-7530&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1520109249%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1520109249&rft_id=info:pmid/24778009&rfr_iscdi=true |