MALDI imaging on tissue microarrays identifies molecular features associated with renal cell cancer phenotype

To identify molecular features associated with clinico-pathological parameters in renal cell cancer. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging was employed for a kidney cancer tissue microarray containing tissue samples from 789 patients for which clinical follow-...

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Veröffentlicht in:	Anticancer research 2014-05, Vol.34 (5), p.2255-2261
Hauptverfasser:	Steurer, Stefan, Seddiqi, Ahmad Shoaib, Singer, Julius Magnus, Bahar, Ahmad Soliaman, Eichelberg, Christian, Rink, Michael, Dahlem, Roland, Huland, Hartwig, Sauter, Guido, Simon, Ronald, Minner, Sarah, Burandt, Eike, Stahl, Phillip R, Schlomm, Thorsten, Wurlitzer, Marcus, Schlüter, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - pathology Female Humans Kidney Neoplasms - metabolism Kidney Neoplasms - mortality Kidney Neoplasms - pathology Male Middle Aged Neoplasm Grading Neoplasm Staging Phenotype Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Tissue Array Analysis - methods
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Zusammenfassung:	To identify molecular features associated with clinico-pathological parameters in renal cell cancer. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging was employed for a kidney cancer tissue microarray containing tissue samples from 789 patients for which clinical follow-up data were available. A comparison of mass spectrometric signals with clinico-pathological features revealed significant differences between papillary and clear cell renal cell cancer. Within the subgroup of clear cell RCC, statistical associations with tumor stage (seven signals, p
ISSN:	1791-7530