Effect of m-calpain in PKCalpha-mediated proliferation of pulmonary artery smooth muscle cells by low dose of ouabain

There is growing evidence that ouabain, a cardiotonic steroid may promote growth of cardiac and vascular myocytes, indicating its novel role in cell growth and proliferation, without appreciable inhibition of the sodium pump. The mechanism(s) by which low dose of ouabain produces pulmonary artery sm...

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Veröffentlicht in:	Indian journal of biochemistry & biophysics 2013-10, Vol.50 (5), p.419-427
Hauptverfasser:	Shaikh, Soni, Sarkar, Jaganmay, Pramanik, Asmita, Karmakar, Kanchan, Chakraborti, Sajal
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Calpain - metabolism Cattle Caveolae - drug effects Caveolae - metabolism Cell Cycle - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Enzyme Activation - drug effects Molecular Sequence Data Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Ouabain - pharmacology Protein Kinase C-alpha - chemistry Protein Kinase C-alpha - metabolism Proteolysis - drug effects Pulmonary Artery - cytology Sodium-Potassium-Exchanging ATPase - metabolism
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