Assessing the Impact of HER2 Status on the Antitumor Activity of an HSP90 Inhibitor in Human Tumor Xenograft Mice Using Pharmacokinetic–Pharmacodynamic Modeling

The purpose of this study is to assess the impact of human epidermal growth factor receptor 2 (HER2) status on the antitumor activity of CH5164840, an orally available heat shock protein 90 (HSP90) inhibitor, using pharmacokinetic–pharmacodynamic modeling. Athymic mice, each implanted with one of ei...

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Veröffentlicht in:	DRUG METABOLISM AND PHARMACOKINETICS 2014, Vol.29 (2), p.185-191
Hauptverfasser:	Saitoh, Ryoichi, Nagayasu, Miho, Shibahara, Norihito, Ono, Naomi, Suda, Atsushi, Kato, Motohiro, Ishigai, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals anticancer Antineoplastic Agents - blood Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Benzoquinones - administration & dosage Benzoquinones - blood Benzoquinones - pharmacokinetics Benzoquinones - pharmacology Biomarkers, Tumor - metabolism Cell Line, Tumor dose-response Dose-Response Relationship, Drug Female HSP90 HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Humans Lactams, Macrocyclic - administration & dosage Lactams, Macrocyclic - blood Lactams, Macrocyclic - pharmacokinetics Lactams, Macrocyclic - pharmacology mathematical model Mice, Nude Models, Biological Neoplasms - blood Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - pathology pharmacodynamics pharmacokinetic/pharmacodynamic models pharmacokinetics Receptor, ErbB-2 - metabolism Tumor Burden - drug effects Xenograft Model Antitumor Assays
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