Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1)

Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1). Since MRP1 mediates resistance to a variety of therapeutic drugs, we investigated whether the cellular folate concentration influences the MRP1-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer chemotherapy and pharmacology 2014-05, Vol.73 (5), p.911-917
Hauptverfasser:	Hooijberg, Jan Hendrik, Jansen, Gerrit, Kathmann, Ietje, Pieters, Rob, Laan, Adrie C., van Zantwijk, Ina, Kaspers, Gertjan J. L., Peters, Godefridus J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Biological Transport Cancer Research Cell Line, Tumor Drug Resistance - drug effects Folic Acid - metabolism Humans Medical sciences Medicine Medicine & Public Health Methotrexate - pharmacology Multidrug Resistance-Associated Proteins - drug effects Multidrug Resistance-Associated Proteins - metabolism Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!