Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

Lgr4 and Lgr5 are known markers of adult and embryonic tissue stem cells in various organs. However, whether Lgr4 and Lgr5 are important for embryonic development remains unclear. To study their functions during intestinal crypt, skin and kidney development we now generated mice lacking either Lgr4...

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Veröffentlicht in:	Developmental biology 2014-06, Vol.390 (2), p.181-190
Hauptverfasser:	Kinzel, Bernd, Pikiolek, Monika, Orsini, Vanessa, Sprunger, Joëlle, Isken, Andrea, Zietzling, Svenja, Desplanches, Magali, Dubost, Valerie, Breustedt, Daniel, Valdez, Reginald, Liu, Dong, Theil, Diethilde, Müller, Matthias, Dietrich, Bill, Bouwmeester, Tewis, Ruffner, Heinz, Tchorz, Jan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Southern DNA Primers - genetics Gene Components Genotype Green Fluorescent Proteins Immunohistochemistry Intestine Intestines - embryology Kidney Kidney - embryology Mice Mice, Inbred BALB C Mice, Knockout Mouse development Polymerase Chain Reaction Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - physiology Reverse Transcriptase Polymerase Chain Reaction Skin Skin - embryology Stem Cells - physiology Tissue stem cell Wnt signaling Wnt Signaling Pathway - genetics Wnt Signaling Pathway - physiology
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