RASSF10 is epigenetically inactivated and induces apoptosis in lung cancer cell lines

Abstract Ras-association domain family 10 (RASSF10), the latest member of the RASSF family with Ras effector function, has been frequently inactivated by aberrant promoter hypermethylation in several human cancers. However, its role in lung cancer has remained unclear. In this study, we investigated...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2014-04, Vol.68 (3), p.321-326
Hauptverfasser:	Wang, Yanfu, Ma, Tianxiao, Bi, Jing, Song, Bo, Zhou, Ying, Zhang, Caihua, Gao, Mingyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - genetics Azacitidine - analogs & derivatives Azacitidine - pharmacology Blotting, Western Cell Culture Techniques Cell Line, Tumor COBRA DNA Methylation - drug effects Epigenesis, Genetic - drug effects Gene Knockdown Techniques Humans Internal Medicine Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Medical Education Methylation Microscopy, Fluorescence RASSF10 RNA, Small Interfering - genetics Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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