Early reversible induction of leukotriene synthesis in chicken myelomonocytic cells transformed by a temperature-sensitive mutant of avian leukemia virus E26

We used chicken myelomonocytic cells transformed by a temperature-sensitive mutant of the myb/ets oncogene-containing avian leukemia virus E26 to study the regulation of leukotriene (LT) synthesis during macrophage differentiation. Cells exposed to arachidonic acid and the Ca2+ ionophore 23187 produ...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-02, Vol.86 (3), p.921-924
Hauptverfasser:	Habenicht, A.J.R, Goerig, M, Rothe, D.E.R, Specht, E, Ziegler, R, Glomset, J.A, Graf, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Arachidonic Acid Arachidonic Acids - metabolism avian leukosis virus Avian Leukosis Virus - genetics AVIAN ONCOVIRUS Biological and medical sciences Blood cells Bone marrow Cell Line Cell Transformation, Neoplastic CELLS Cells, Cultured Cellular differentiation CELLULE CELULAS CHICKENS Cycloheximide - pharmacology Dactinomycin - pharmacology FAGOCITOS FONCTION PHYSIOLOGIQUE FUNCION FISIOLOGICA Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Kinetics Leukotriene B4 - biosynthesis Leukotrienes Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - metabolism METABOLITE METABOLITES METABOLITOS MUTANT MUTANTES MUTANTS Mutation Myeloid cells: ontogeny, maturation, markers, receptors N-Formylmethionine Leucyl-Phenylalanine - pharmacology Oncogenes ONCOVIRUS AVIAIRE ONCOVIRUS AVIAR PHAGOCYTE PHAGOCYTES PHYSIOLOGICAL FUNCTIONS POLLO POULET SRS-A - biosynthesis TEMPERATURA TEMPERATURE Up regulation Viruses
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