Isolation of a pure octadecasaccharide with antithrombin activity from an ultra-low-molecular-weight heparin

Heparin and low-molecular-weight heparins (LMWHs) are anticoagulant drugs that mainly inhibit the coagulation cascade by indirectly interacting with factor Xa and factor IIa (thrombin). Inhibition of factor Xa by antithrombin (AT) requires the activation of AT by specific pentasaccharide sequences c...

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Veröffentlicht in:	Analytical biochemistry 2014-05, Vol.453, p.7-15
Hauptverfasser:	Mourier, Pierre A.J., Guichard, Olivier Y., Herman, Frédéric, Viskov, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-factor IIa Antithrombin Antithrombins - chemistry Antithrombins - isolation & purification Antithrombins - pharmacology Carbohydrate Conformation Carbohydrate Sequence Dose-Response Relationship, Drug Enzymatic sequencing Enzyme Activation - drug effects Factor Xa - metabolism Glycosaminoglycan 3-O-sulfation Heparin Heparin, Low-Molecular-Weight - chemistry Molecular Sequence Data Molecular Weight NMR Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology Structure-Activity Relationship Thrombin - antagonists & inhibitors Thrombin - metabolism
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