Differences in the prevalence of metabolic disorders between prepubertal boys and girls from 5 to 8 years of age
Aim To determine the prevalence of metabolic abnormalities, and differences between the sexes, in prepubertal overweight and normal weight children aged from 5 to 8 years, without any signs of health impairments or metabolic disturbances at the time of recruitment. Methods General health status and...
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| Veröffentlicht in: | Acta Paediatrica 2014-04, Vol.103 (4), p.e154-e160 |
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| container_title | Acta Paediatrica |
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| creator | Maier, Ina B. Özel, Yelda Engstler, Anna Janina Puchinger, Sonja Wagnerberger, Sabine Hulpke-Wette, Martin Bischoff, Stephan C. Bergheim, Ina |
| description | Aim
To determine the prevalence of metabolic abnormalities, and differences between the sexes, in prepubertal overweight and normal weight children aged from 5 to 8 years, without any signs of health impairments or metabolic disturbances at the time of recruitment.
Methods
General health status and inflammatory markers were assessed in 100 overweight and 51 normal weight children, who were living in Germany and had undergone mandatory medical examinations. The study comprised of 81 girls and 70 boys.
Results
Despite being recruited as healthy, 73% of the overweight children and 16% of the normal weight children were found to suffer from one or more metabolic abnormalities, such as hypertension or insulin resistance. Girls with a body mass index (BMI) percentile of ≥80th showed an increased susceptibility to metabolic disorders, and a similar effect was found for boys with a BMI percentile of ≥95th. Plasma levels of pro‐inflammatory markers, such as plasminogen activator inhibitor‐1 and leptin, were also significantly higher in overweight than normal weight children.
Conclusion
Metabolic and cardiovascular abnormalities and pro‐inflammatory markers were prevalent in overweight prepubertal children. The prevalence rates appeared to differ between the sexes. |
| doi_str_mv | 10.1111/apa.12546 |
| format | Article |
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To determine the prevalence of metabolic abnormalities, and differences between the sexes, in prepubertal overweight and normal weight children aged from 5 to 8 years, without any signs of health impairments or metabolic disturbances at the time of recruitment.
Methods
General health status and inflammatory markers were assessed in 100 overweight and 51 normal weight children, who were living in Germany and had undergone mandatory medical examinations. The study comprised of 81 girls and 70 boys.
Results
Despite being recruited as healthy, 73% of the overweight children and 16% of the normal weight children were found to suffer from one or more metabolic abnormalities, such as hypertension or insulin resistance. Girls with a body mass index (BMI) percentile of ≥80th showed an increased susceptibility to metabolic disorders, and a similar effect was found for boys with a BMI percentile of ≥95th. Plasma levels of pro‐inflammatory markers, such as plasminogen activator inhibitor‐1 and leptin, were also significantly higher in overweight than normal weight children.
Conclusion
Metabolic and cardiovascular abnormalities and pro‐inflammatory markers were prevalent in overweight prepubertal children. The prevalence rates appeared to differ between the sexes.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.12546</identifier><identifier>PMID: 24761461</identifier><language>eng</language><publisher>Norway: Blackwell Publishing Ltd</publisher><subject>Child ; Child, Preschool ; Children ; Children & youth ; Female ; Girls ; Humans ; Inflammatory markers ; Male ; Metabolic abnormality ; Metabolic Diseases - complications ; Metabolic Diseases - epidemiology ; Metabolic disorders ; Overweight ; Overweight - complications ; Prevalence ; Sex Factors ; Sexual differences</subject><ispartof>Acta Paediatrica, 2014-04, Vol.103 (4), p.e154-e160</ispartof><rights>2013 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd</rights><rights>Copyright © 2014 Foundation Acta Pædiatrica</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5626-34e2e8275c25a70fb097764a2de52d933b70fbfd6447faaf496f82f378e25d7e3</citedby><cites>FETCH-LOGICAL-c5626-34e2e8275c25a70fb097764a2de52d933b70fbfd6447faaf496f82f378e25d7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.12546$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.12546$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24761461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maier, Ina B.</creatorcontrib><creatorcontrib>Özel, Yelda</creatorcontrib><creatorcontrib>Engstler, Anna Janina</creatorcontrib><creatorcontrib>Puchinger, Sonja</creatorcontrib><creatorcontrib>Wagnerberger, Sabine</creatorcontrib><creatorcontrib>Hulpke-Wette, Martin</creatorcontrib><creatorcontrib>Bischoff, Stephan C.</creatorcontrib><creatorcontrib>Bergheim, Ina</creatorcontrib><title>Differences in the prevalence of metabolic disorders between prepubertal boys and girls from 5 to 8 years of age</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim
To determine the prevalence of metabolic abnormalities, and differences between the sexes, in prepubertal overweight and normal weight children aged from 5 to 8 years, without any signs of health impairments or metabolic disturbances at the time of recruitment.
Methods
General health status and inflammatory markers were assessed in 100 overweight and 51 normal weight children, who were living in Germany and had undergone mandatory medical examinations. The study comprised of 81 girls and 70 boys.
Results
Despite being recruited as healthy, 73% of the overweight children and 16% of the normal weight children were found to suffer from one or more metabolic abnormalities, such as hypertension or insulin resistance. Girls with a body mass index (BMI) percentile of ≥80th showed an increased susceptibility to metabolic disorders, and a similar effect was found for boys with a BMI percentile of ≥95th. Plasma levels of pro‐inflammatory markers, such as plasminogen activator inhibitor‐1 and leptin, were also significantly higher in overweight than normal weight children.
Conclusion
Metabolic and cardiovascular abnormalities and pro‐inflammatory markers were prevalent in overweight prepubertal children. The prevalence rates appeared to differ between the sexes.</description><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Female</subject><subject>Girls</subject><subject>Humans</subject><subject>Inflammatory markers</subject><subject>Male</subject><subject>Metabolic abnormality</subject><subject>Metabolic Diseases - complications</subject><subject>Metabolic Diseases - epidemiology</subject><subject>Metabolic disorders</subject><subject>Overweight</subject><subject>Overweight - complications</subject><subject>Prevalence</subject><subject>Sex Factors</subject><subject>Sexual differences</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EotvCgT-ALHGBQ1p7_JUctwXaShWgAuJoOcm4pCRxsBPa_fd4u20PSMzF0uh5H438EvKKs0Oe58hN7pCDkvoJWXGteAEA5ilZsZKJQoESe2Q_pWvGQFRSPyd7II3mUvMVmd533mPEscFEu5HOP5FOEf-4fruiwdMBZ1eHvmto26UQW4yJ1jjfII5bclpqjLPraR02ibqxpVdd7BP1MQxU0TnQkm7Q5VB2uSt8QZ551yd8ef8ekO8fP3w7OSsuPp-en6wvikZp0IWQCFiCUQ0oZ5ivWWWMlg5aVNBWQtTbpW-1lMY752WlfQlemBJBtQbFAXm7804x_F4wzXboUoN970YMS7Jc8QqUZpJl9M0_6HVY4pivyxTTpgTOdKbe7agmhpQiejvFbnBxYzmz2xpsrsHe1ZDZ1_fGpR6wfSQf_j0DRzvgputx83-TXX9ZPyiLXaJLM94-Jlz8ZbURRtkfn07t5dnlMf8KwgrxF4pbn2Y</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Maier, Ina B.</creator><creator>Özel, Yelda</creator><creator>Engstler, Anna Janina</creator><creator>Puchinger, Sonja</creator><creator>Wagnerberger, Sabine</creator><creator>Hulpke-Wette, Martin</creator><creator>Bischoff, Stephan C.</creator><creator>Bergheim, Ina</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Differences in the prevalence of metabolic disorders between prepubertal boys and girls from 5 to 8 years of age</title><author>Maier, Ina B. ; Özel, Yelda ; Engstler, Anna Janina ; Puchinger, Sonja ; Wagnerberger, Sabine ; Hulpke-Wette, Martin ; Bischoff, Stephan C. ; Bergheim, Ina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5626-34e2e8275c25a70fb097764a2de52d933b70fbfd6447faaf496f82f378e25d7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Female</topic><topic>Girls</topic><topic>Humans</topic><topic>Inflammatory markers</topic><topic>Male</topic><topic>Metabolic abnormality</topic><topic>Metabolic Diseases - complications</topic><topic>Metabolic Diseases - epidemiology</topic><topic>Metabolic disorders</topic><topic>Overweight</topic><topic>Overweight - complications</topic><topic>Prevalence</topic><topic>Sex Factors</topic><topic>Sexual differences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maier, Ina B.</creatorcontrib><creatorcontrib>Özel, Yelda</creatorcontrib><creatorcontrib>Engstler, Anna Janina</creatorcontrib><creatorcontrib>Puchinger, Sonja</creatorcontrib><creatorcontrib>Wagnerberger, Sabine</creatorcontrib><creatorcontrib>Hulpke-Wette, Martin</creatorcontrib><creatorcontrib>Bischoff, Stephan C.</creatorcontrib><creatorcontrib>Bergheim, Ina</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maier, Ina B.</au><au>Özel, Yelda</au><au>Engstler, Anna Janina</au><au>Puchinger, Sonja</au><au>Wagnerberger, Sabine</au><au>Hulpke-Wette, Martin</au><au>Bischoff, Stephan C.</au><au>Bergheim, Ina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in the prevalence of metabolic disorders between prepubertal boys and girls from 5 to 8 years of age</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2014-04</date><risdate>2014</risdate><volume>103</volume><issue>4</issue><spage>e154</spage><epage>e160</epage><pages>e154-e160</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim
To determine the prevalence of metabolic abnormalities, and differences between the sexes, in prepubertal overweight and normal weight children aged from 5 to 8 years, without any signs of health impairments or metabolic disturbances at the time of recruitment.
Methods
General health status and inflammatory markers were assessed in 100 overweight and 51 normal weight children, who were living in Germany and had undergone mandatory medical examinations. The study comprised of 81 girls and 70 boys.
Results
Despite being recruited as healthy, 73% of the overweight children and 16% of the normal weight children were found to suffer from one or more metabolic abnormalities, such as hypertension or insulin resistance. Girls with a body mass index (BMI) percentile of ≥80th showed an increased susceptibility to metabolic disorders, and a similar effect was found for boys with a BMI percentile of ≥95th. Plasma levels of pro‐inflammatory markers, such as plasminogen activator inhibitor‐1 and leptin, were also significantly higher in overweight than normal weight children.
Conclusion
Metabolic and cardiovascular abnormalities and pro‐inflammatory markers were prevalent in overweight prepubertal children. The prevalence rates appeared to differ between the sexes.</abstract><cop>Norway</cop><pub>Blackwell Publishing Ltd</pub><pmid>24761461</pmid><doi>10.1111/apa.12546</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta Paediatrica, 2014-04, Vol.103 (4), p.e154-e160 |
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| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Child Child, Preschool Children Children & youth Female Girls Humans Inflammatory markers Male Metabolic abnormality Metabolic Diseases - complications Metabolic Diseases - epidemiology Metabolic disorders Overweight Overweight - complications Prevalence Sex Factors Sexual differences |
| title | Differences in the prevalence of metabolic disorders between prepubertal boys and girls from 5 to 8 years of age |
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