Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase Cα

[Display omitted] •Expression of syndecan-4 enhances cellular uptake of octaarginine (R8) peptide.•R8 induces syndecan-4 clustering on plasma membranes.•Syndecan-4 clustering enhances the binding of PKCα in the cytosol.•Cytoplasmic V domain of syndecan-4 is important for R8 cellular uptake. Arginine...

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