Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells
The synthetic nonapeptide 1-desamino-8-D-arginine vasopressin (dDAVP) can reduce tumor cell growth through agonist action on the vasopressin V2 receptor. A structure-antiproliferative activity relationship analysis of dDAVP was performed using the alanine scanning technique on the aggressive MDA-MB-...
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creator | PASTRIAN, MARÍA B GUZMÁN, FANNY GARONA, JUAN PIFANO, MARINA RIPOLL, GISELLE V CASCONE, OSVALDO CICCIA, GRACIELA N ALBERICIO, FERNANDO GÓMEZ, DANIEL E ALONSO, DANIEL F IANNUCCI, NANCY B |
description | The synthetic nonapeptide 1-desamino-8-D-arginine vasopressin (dDAVP) can reduce tumor cell growth through agonist action on the vasopressin V2 receptor. A structure-antiproliferative activity relationship analysis of dDAVP was performed using the alanine scanning technique on the aggressive MDA-MB-231 human breast carcinoma cell line. The results from this analysis demonstrated that the amino acids located at the loop of dDAVP are important for the antiproliferative activity of dDAVP, highlighting the key role of the N-terminal region of the peptide in the interaction with the tumor cell surface receptor. The findings from this study present novel strategies for designing improved compounds with enhanced stability for cancer therapy. |
doi_str_mv | 10.3892/mmr.2014.2140 |
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A structure-antiproliferative activity relationship analysis of dDAVP was performed using the alanine scanning technique on the aggressive MDA-MB-231 human breast carcinoma cell line. The results from this analysis demonstrated that the amino acids located at the loop of dDAVP are important for the antiproliferative activity of dDAVP, highlighting the key role of the N-terminal region of the peptide in the interaction with the tumor cell surface receptor. The findings from this study present novel strategies for designing improved compounds with enhanced stability for cancer therapy.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2014.2140</identifier><identifier>PMID: 24737067</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Ala-scanning ; Alanine ; Amino Acid Sequence ; Amino acids ; Arginine ; Argipressin ; Breast cancer ; Breast carcinoma ; Bridges ; Cancer cells ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell surface ; Chemical properties ; cytostatic effect ; Deamino Arginine Vasopressin - analogs & derivatives ; Deamino Arginine Vasopressin - chemistry ; Deamino Arginine Vasopressin - pharmacology ; desmopressin ; Humans ; Metastasis ; Molecular weight ; Mutagenesis ; Peptides ; Physiological aspects ; Receptors, Vasopressin - agonists ; Receptors, Vasopressin - chemistry ; Scanning ; Structure-Activity Relationship ; Structure-activity relationships (Biochemistry) ; Studies ; Tumor Stem Cell Assay ; V2 receptor ; Vasopressin ; vasopressin analogs</subject><ispartof>Molecular medicine reports, 2014-06, Vol.9 (6), p.2568-2572</ispartof><rights>Copyright © 2014, Spandidos Publications</rights><rights>COPYRIGHT 2014 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-ea5a11ec55f801cf5e182b59cbeaf4cdbe0c08c982fb214fe51e1964b928833f3</citedby><cites>FETCH-LOGICAL-c459t-ea5a11ec55f801cf5e182b59cbeaf4cdbe0c08c982fb214fe51e1964b928833f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,5570,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24737067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PASTRIAN, MARÍA B</creatorcontrib><creatorcontrib>GUZMÁN, FANNY</creatorcontrib><creatorcontrib>GARONA, JUAN</creatorcontrib><creatorcontrib>PIFANO, MARINA</creatorcontrib><creatorcontrib>RIPOLL, GISELLE V</creatorcontrib><creatorcontrib>CASCONE, OSVALDO</creatorcontrib><creatorcontrib>CICCIA, GRACIELA N</creatorcontrib><creatorcontrib>ALBERICIO, FERNANDO</creatorcontrib><creatorcontrib>GÓMEZ, DANIEL E</creatorcontrib><creatorcontrib>ALONSO, DANIEL F</creatorcontrib><creatorcontrib>IANNUCCI, NANCY B</creatorcontrib><title>Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>The synthetic nonapeptide 1-desamino-8-D-arginine vasopressin (dDAVP) can reduce tumor cell growth through agonist action on the vasopressin V2 receptor. A structure-antiproliferative activity relationship analysis of dDAVP was performed using the alanine scanning technique on the aggressive MDA-MB-231 human breast carcinoma cell line. The results from this analysis demonstrated that the amino acids located at the loop of dDAVP are important for the antiproliferative activity of dDAVP, highlighting the key role of the N-terminal region of the peptide in the interaction with the tumor cell surface receptor. The findings from this study present novel strategies for designing improved compounds with enhanced stability for cancer therapy.</description><subject>Ala-scanning</subject><subject>Alanine</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Arginine</subject><subject>Argipressin</subject><subject>Breast cancer</subject><subject>Breast carcinoma</subject><subject>Bridges</subject><subject>Cancer cells</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell surface</subject><subject>Chemical properties</subject><subject>cytostatic effect</subject><subject>Deamino Arginine Vasopressin - analogs & derivatives</subject><subject>Deamino Arginine Vasopressin - chemistry</subject><subject>Deamino Arginine Vasopressin - pharmacology</subject><subject>desmopressin</subject><subject>Humans</subject><subject>Metastasis</subject><subject>Molecular weight</subject><subject>Mutagenesis</subject><subject>Peptides</subject><subject>Physiological aspects</subject><subject>Receptors, Vasopressin - agonists</subject><subject>Receptors, Vasopressin - chemistry</subject><subject>Scanning</subject><subject>Structure-Activity Relationship</subject><subject>Structure-activity relationships (Biochemistry)</subject><subject>Studies</subject><subject>Tumor Stem Cell Assay</subject><subject>V2 receptor</subject><subject>Vasopressin</subject><subject>vasopressin analogs</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkkuPFCEUhStG44yjS7eGxIWzoeVRVMFyMjpqMokLH1tCUZceJlVQAtVxfoz_VTrdjo8YEiA33z33BE7TPKdkw6Vir-c5bRih7YbRljxoTmmvKOaEtA-Pd6ZUf9I8yfmWkE4woR43J6zteU-6_rT58amk1ZY1ATa2-J0vdyjBZIqPId_4BUWHKB4hm9mHiCV-g03a-uADoJ3JcUmQsw_IZGTqHopfUpy8g1QldoDMFkJBMaCbda7Any1fWZ1kYSkxYfh-rG6RNcFCQhamKT9tHjkzZXh2PM-aL1dvP1--x9cf3324vLjGthWqYDDCUApWCCcJtU4AlWwQyg5gXGvHAYgl0irJ3FCfyYGgQFXXDopJybnjZ835Qbea_7ZCLnr2ee_ABIhr1lRQKWnPBK_oy3_Q27imUN1pqjhrO95J8Zvamgm0Dy6WZOxeVF-0VHSqUz2p1OY_VF0jzN7GAM7X-l8N-NBgU8w5gdNL8rNJd5oSvY-DrnHQ-zjofRwq_-Jodh1mGO_pX_9fgVcHIC8mjH6M-Z6pSpgoTDrMRCf5T4nIv88</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>PASTRIAN, MARÍA B</creator><creator>GUZMÁN, FANNY</creator><creator>GARONA, JUAN</creator><creator>PIFANO, MARINA</creator><creator>RIPOLL, GISELLE V</creator><creator>CASCONE, OSVALDO</creator><creator>CICCIA, GRACIELA N</creator><creator>ALBERICIO, FERNANDO</creator><creator>GÓMEZ, DANIEL E</creator><creator>ALONSO, DANIEL F</creator><creator>IANNUCCI, NANCY B</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells</title><author>PASTRIAN, MARÍA B ; GUZMÁN, FANNY ; GARONA, JUAN ; PIFANO, MARINA ; RIPOLL, GISELLE V ; CASCONE, OSVALDO ; CICCIA, GRACIELA N ; ALBERICIO, FERNANDO ; GÓMEZ, DANIEL E ; ALONSO, DANIEL F ; IANNUCCI, NANCY B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-ea5a11ec55f801cf5e182b59cbeaf4cdbe0c08c982fb214fe51e1964b928833f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Ala-scanning</topic><topic>Alanine</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Arginine</topic><topic>Argipressin</topic><topic>Breast cancer</topic><topic>Breast carcinoma</topic><topic>Bridges</topic><topic>Cancer cells</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell surface</topic><topic>Chemical properties</topic><topic>cytostatic effect</topic><topic>Deamino Arginine Vasopressin - analogs & derivatives</topic><topic>Deamino Arginine Vasopressin - chemistry</topic><topic>Deamino Arginine Vasopressin - pharmacology</topic><topic>desmopressin</topic><topic>Humans</topic><topic>Metastasis</topic><topic>Molecular weight</topic><topic>Mutagenesis</topic><topic>Peptides</topic><topic>Physiological aspects</topic><topic>Receptors, Vasopressin - agonists</topic><topic>Receptors, Vasopressin - chemistry</topic><topic>Scanning</topic><topic>Structure-Activity Relationship</topic><topic>Structure-activity relationships (Biochemistry)</topic><topic>Studies</topic><topic>Tumor Stem Cell Assay</topic><topic>V2 receptor</topic><topic>Vasopressin</topic><topic>vasopressin analogs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PASTRIAN, MARÍA B</creatorcontrib><creatorcontrib>GUZMÁN, FANNY</creatorcontrib><creatorcontrib>GARONA, JUAN</creatorcontrib><creatorcontrib>PIFANO, MARINA</creatorcontrib><creatorcontrib>RIPOLL, GISELLE V</creatorcontrib><creatorcontrib>CASCONE, OSVALDO</creatorcontrib><creatorcontrib>CICCIA, GRACIELA N</creatorcontrib><creatorcontrib>ALBERICIO, FERNANDO</creatorcontrib><creatorcontrib>GÓMEZ, DANIEL E</creatorcontrib><creatorcontrib>ALONSO, DANIEL F</creatorcontrib><creatorcontrib>IANNUCCI, NANCY B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PASTRIAN, MARÍA B</au><au>GUZMÁN, FANNY</au><au>GARONA, JUAN</au><au>PIFANO, MARINA</au><au>RIPOLL, GISELLE V</au><au>CASCONE, OSVALDO</au><au>CICCIA, GRACIELA N</au><au>ALBERICIO, FERNANDO</au><au>GÓMEZ, DANIEL E</au><au>ALONSO, DANIEL F</au><au>IANNUCCI, NANCY B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>9</volume><issue>6</issue><spage>2568</spage><epage>2572</epage><pages>2568-2572</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>The synthetic nonapeptide 1-desamino-8-D-arginine vasopressin (dDAVP) can reduce tumor cell growth through agonist action on the vasopressin V2 receptor. A structure-antiproliferative activity relationship analysis of dDAVP was performed using the alanine scanning technique on the aggressive MDA-MB-231 human breast carcinoma cell line. The results from this analysis demonstrated that the amino acids located at the loop of dDAVP are important for the antiproliferative activity of dDAVP, highlighting the key role of the N-terminal region of the peptide in the interaction with the tumor cell surface receptor. The findings from this study present novel strategies for designing improved compounds with enhanced stability for cancer therapy.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>24737067</pmid><doi>10.3892/mmr.2014.2140</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Ala-scanning Alanine Amino Acid Sequence Amino acids Arginine Argipressin Breast cancer Breast carcinoma Bridges Cancer cells Cell Line, Tumor Cell Proliferation - drug effects Cell surface Chemical properties cytostatic effect Deamino Arginine Vasopressin - analogs & derivatives Deamino Arginine Vasopressin - chemistry Deamino Arginine Vasopressin - pharmacology desmopressin Humans Metastasis Molecular weight Mutagenesis Peptides Physiological aspects Receptors, Vasopressin - agonists Receptors, Vasopressin - chemistry Scanning Structure-Activity Relationship Structure-activity relationships (Biochemistry) Studies Tumor Stem Cell Assay V2 receptor Vasopressin vasopressin analogs |
title | Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells |
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