Comparison of treatment modalities for Contact granuloma: A Nationwide Multicenter Study
Objectives/Hypothesis This study evaluated the efficacy of commonly used treatment modalities and determined predictors of treatment outcome for contact granuloma. Study Design Retrospective study. Methods Twenty otolaryngologists from 18 university hospitals reviewed the medical records of their ow...
Gespeichert in:
| Veröffentlicht in: | The Laryngoscope 2014-05, Vol.124 (5), p.1187-1191 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1191 |
|---|---|
| container_issue | 5 |
| container_start_page | 1187 |
| container_title | The Laryngoscope |
| container_volume | 124 |
| creator | Lee, Seung Won Hong, Hyung Jun Choi, Seung Ho Sun, Dong IL Park, Young Hak Lee, Byung Joo Kwon, Seong Keun Park, IL Seok Lee, Sang Hyuk Son, Young-Ik |
| description | Objectives/Hypothesis
This study evaluated the efficacy of commonly used treatment modalities and determined predictors of treatment outcome for contact granuloma.
Study Design
Retrospective study.
Methods
Twenty otolaryngologists from 18 university hospitals reviewed the medical records of their own contact granuloma patients for the most recent 4 years. To be enrolled as a valid case, each treatment had to continue for at least 3 months. After excluding intubation granuloma, 590 cases of contact granuloma were analyzed. Treatment outcomes were assessed as complete response (CR), marked response (MR), partial response (PR), and no response. The chi‐square test was used to compare the efficacy of each treatment modality and logistic regression to determine the predictors of treatment outcome.
Results
The long‐term outcomes of good response (GR) (sum of CR and MR) rates after each treatment were 20.5% for observation, 31.6% for steroid inhalation, 44.0% for proton pump inhibitor (PPI), 44.3% for voice therapy, 60.0% for surgical removal, and 74.2% for botulinum toxin injection. Voice therapy, PPI, and botulinum toxin had more good responses than simple observation for the long‐term outcome (P |
| doi_str_mv | 10.1002/lary.24470 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1518623076</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1518623076</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4610-258a32fbc2287a52ac48d45d53551484216f9289b1ebf4bb0a2987fd7dbd13343</originalsourceid><addsrcrecordid>eNp9kM1O3DAUhS1UBMO0mz4AstRNhZTBv7HT3Sj8M6USUJWuLCd2kGkST21HMG9PpgMsWHR1F_c7R_d-AHzGaIYRIoetDqsZYUygLTDBnOKMFQX_ACbjkmaSk7tdsBfjA0JYUI52wC5hFAkm-QTclb5b6uCi76FvYApWp872CXbe6NYlZyNsfICl75OuE7wPuh9a3-lvcA6vdHK-f3TGwu9Dm1w9Bm2AN2kwq49gu9FttJ9e5hT8PDm-Lc-yxY_T83K-yGqWY5QRLjUlTVUTIoXmRNdMGsYNp5xjJhnBeVMQWVTYVg2rKqRJIUVjhKkMppTRKfi66V0G_3ewManOxdq2re6tH6LCHMucjO_mI_rlHfrgh9CP160pwZkQbE0dbKg6-BiDbdQyuG5UrDBSa99q7Vv98z3C-y-VQ9VZ84a-Ch4BvAEeXWtX_6lSi_n179fSbJNxMdmnt4wOf1QuqODq19Wpurgl6PKoFGpBnwGjl5lE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1517547746</pqid></control><display><type>article</type><title>Comparison of treatment modalities for Contact granuloma: A Nationwide Multicenter Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lee, Seung Won ; Hong, Hyung Jun ; Choi, Seung Ho ; Sun, Dong IL ; Park, Young Hak ; Lee, Byung Joo ; Kwon, Seong Keun ; Park, IL Seok ; Lee, Sang Hyuk ; Son, Young-Ik</creator><creatorcontrib>Lee, Seung Won ; Hong, Hyung Jun ; Choi, Seung Ho ; Sun, Dong IL ; Park, Young Hak ; Lee, Byung Joo ; Kwon, Seong Keun ; Park, IL Seok ; Lee, Sang Hyuk ; Son, Young-Ik</creatorcontrib><description>Objectives/Hypothesis
This study evaluated the efficacy of commonly used treatment modalities and determined predictors of treatment outcome for contact granuloma.
Study Design
Retrospective study.
Methods
Twenty otolaryngologists from 18 university hospitals reviewed the medical records of their own contact granuloma patients for the most recent 4 years. To be enrolled as a valid case, each treatment had to continue for at least 3 months. After excluding intubation granuloma, 590 cases of contact granuloma were analyzed. Treatment outcomes were assessed as complete response (CR), marked response (MR), partial response (PR), and no response. The chi‐square test was used to compare the efficacy of each treatment modality and logistic regression to determine the predictors of treatment outcome.
Results
The long‐term outcomes of good response (GR) (sum of CR and MR) rates after each treatment were 20.5% for observation, 31.6% for steroid inhalation, 44.0% for proton pump inhibitor (PPI), 44.3% for voice therapy, 60.0% for surgical removal, and 74.2% for botulinum toxin injection. Voice therapy, PPI, and botulinum toxin had more good responses than simple observation for the long‐term outcome (P < 0.05). Surgical removal had a significantly higher recurrence rate (37.1%) than simple observation (10.3%) (P < 0.05).
Conclusions
Voice therapy or PPI are recommended as first‐line treatments. Surgical removal should be reserved for selected patients because of the high chance of recurrence. Botulinum toxin injection can be used not only for primary cases but also for refractory cases with an expected high response rate.
Level of Evidence
4. Laryngoscope, 124:1187–1191, 2014</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.24470</identifier><identifier>PMID: 24307485</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Contact granuloma ; Disease Progression ; Drug therapy ; Female ; Granuloma - therapy ; Humans ; Laryngeal Diseases - therapy ; Laryngoscopy ; Male ; Medical research ; Middle Aged ; Recurrence ; Republic of Korea ; Retrospective Studies ; therapeutic ; treatment guideline ; Treatment Outcome</subject><ispartof>The Laryngoscope, 2014-05, Vol.124 (5), p.1187-1191</ispartof><rights>2013 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4610-258a32fbc2287a52ac48d45d53551484216f9289b1ebf4bb0a2987fd7dbd13343</citedby><cites>FETCH-LOGICAL-c4610-258a32fbc2287a52ac48d45d53551484216f9289b1ebf4bb0a2987fd7dbd13343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.24470$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.24470$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24307485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Seung Won</creatorcontrib><creatorcontrib>Hong, Hyung Jun</creatorcontrib><creatorcontrib>Choi, Seung Ho</creatorcontrib><creatorcontrib>Sun, Dong IL</creatorcontrib><creatorcontrib>Park, Young Hak</creatorcontrib><creatorcontrib>Lee, Byung Joo</creatorcontrib><creatorcontrib>Kwon, Seong Keun</creatorcontrib><creatorcontrib>Park, IL Seok</creatorcontrib><creatorcontrib>Lee, Sang Hyuk</creatorcontrib><creatorcontrib>Son, Young-Ik</creatorcontrib><title>Comparison of treatment modalities for Contact granuloma: A Nationwide Multicenter Study</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis
This study evaluated the efficacy of commonly used treatment modalities and determined predictors of treatment outcome for contact granuloma.
Study Design
Retrospective study.
Methods
Twenty otolaryngologists from 18 university hospitals reviewed the medical records of their own contact granuloma patients for the most recent 4 years. To be enrolled as a valid case, each treatment had to continue for at least 3 months. After excluding intubation granuloma, 590 cases of contact granuloma were analyzed. Treatment outcomes were assessed as complete response (CR), marked response (MR), partial response (PR), and no response. The chi‐square test was used to compare the efficacy of each treatment modality and logistic regression to determine the predictors of treatment outcome.
Results
The long‐term outcomes of good response (GR) (sum of CR and MR) rates after each treatment were 20.5% for observation, 31.6% for steroid inhalation, 44.0% for proton pump inhibitor (PPI), 44.3% for voice therapy, 60.0% for surgical removal, and 74.2% for botulinum toxin injection. Voice therapy, PPI, and botulinum toxin had more good responses than simple observation for the long‐term outcome (P < 0.05). Surgical removal had a significantly higher recurrence rate (37.1%) than simple observation (10.3%) (P < 0.05).
Conclusions
Voice therapy or PPI are recommended as first‐line treatments. Surgical removal should be reserved for selected patients because of the high chance of recurrence. Botulinum toxin injection can be used not only for primary cases but also for refractory cases with an expected high response rate.
Level of Evidence
4. Laryngoscope, 124:1187–1191, 2014</description><subject>Contact granuloma</subject><subject>Disease Progression</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Granuloma - therapy</subject><subject>Humans</subject><subject>Laryngeal Diseases - therapy</subject><subject>Laryngoscopy</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Recurrence</subject><subject>Republic of Korea</subject><subject>Retrospective Studies</subject><subject>therapeutic</subject><subject>treatment guideline</subject><subject>Treatment Outcome</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1O3DAUhS1UBMO0mz4AstRNhZTBv7HT3Sj8M6USUJWuLCd2kGkST21HMG9PpgMsWHR1F_c7R_d-AHzGaIYRIoetDqsZYUygLTDBnOKMFQX_ACbjkmaSk7tdsBfjA0JYUI52wC5hFAkm-QTclb5b6uCi76FvYApWp872CXbe6NYlZyNsfICl75OuE7wPuh9a3-lvcA6vdHK-f3TGwu9Dm1w9Bm2AN2kwq49gu9FttJ9e5hT8PDm-Lc-yxY_T83K-yGqWY5QRLjUlTVUTIoXmRNdMGsYNp5xjJhnBeVMQWVTYVg2rKqRJIUVjhKkMppTRKfi66V0G_3ewManOxdq2re6tH6LCHMucjO_mI_rlHfrgh9CP160pwZkQbE0dbKg6-BiDbdQyuG5UrDBSa99q7Vv98z3C-y-VQ9VZ84a-Ch4BvAEeXWtX_6lSi_n179fSbJNxMdmnt4wOf1QuqODq19Wpurgl6PKoFGpBnwGjl5lE</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Lee, Seung Won</creator><creator>Hong, Hyung Jun</creator><creator>Choi, Seung Ho</creator><creator>Sun, Dong IL</creator><creator>Park, Young Hak</creator><creator>Lee, Byung Joo</creator><creator>Kwon, Seong Keun</creator><creator>Park, IL Seok</creator><creator>Lee, Sang Hyuk</creator><creator>Son, Young-Ik</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>Comparison of treatment modalities for Contact granuloma: A Nationwide Multicenter Study</title><author>Lee, Seung Won ; Hong, Hyung Jun ; Choi, Seung Ho ; Sun, Dong IL ; Park, Young Hak ; Lee, Byung Joo ; Kwon, Seong Keun ; Park, IL Seok ; Lee, Sang Hyuk ; Son, Young-Ik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4610-258a32fbc2287a52ac48d45d53551484216f9289b1ebf4bb0a2987fd7dbd13343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Contact granuloma</topic><topic>Disease Progression</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Granuloma - therapy</topic><topic>Humans</topic><topic>Laryngeal Diseases - therapy</topic><topic>Laryngoscopy</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Recurrence</topic><topic>Republic of Korea</topic><topic>Retrospective Studies</topic><topic>therapeutic</topic><topic>treatment guideline</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Seung Won</creatorcontrib><creatorcontrib>Hong, Hyung Jun</creatorcontrib><creatorcontrib>Choi, Seung Ho</creatorcontrib><creatorcontrib>Sun, Dong IL</creatorcontrib><creatorcontrib>Park, Young Hak</creatorcontrib><creatorcontrib>Lee, Byung Joo</creatorcontrib><creatorcontrib>Kwon, Seong Keun</creatorcontrib><creatorcontrib>Park, IL Seok</creatorcontrib><creatorcontrib>Lee, Sang Hyuk</creatorcontrib><creatorcontrib>Son, Young-Ik</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Seung Won</au><au>Hong, Hyung Jun</au><au>Choi, Seung Ho</au><au>Sun, Dong IL</au><au>Park, Young Hak</au><au>Lee, Byung Joo</au><au>Kwon, Seong Keun</au><au>Park, IL Seok</au><au>Lee, Sang Hyuk</au><au>Son, Young-Ik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of treatment modalities for Contact granuloma: A Nationwide Multicenter Study</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2014-05</date><risdate>2014</risdate><volume>124</volume><issue>5</issue><spage>1187</spage><epage>1191</epage><pages>1187-1191</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
This study evaluated the efficacy of commonly used treatment modalities and determined predictors of treatment outcome for contact granuloma.
Study Design
Retrospective study.
Methods
Twenty otolaryngologists from 18 university hospitals reviewed the medical records of their own contact granuloma patients for the most recent 4 years. To be enrolled as a valid case, each treatment had to continue for at least 3 months. After excluding intubation granuloma, 590 cases of contact granuloma were analyzed. Treatment outcomes were assessed as complete response (CR), marked response (MR), partial response (PR), and no response. The chi‐square test was used to compare the efficacy of each treatment modality and logistic regression to determine the predictors of treatment outcome.
Results
The long‐term outcomes of good response (GR) (sum of CR and MR) rates after each treatment were 20.5% for observation, 31.6% for steroid inhalation, 44.0% for proton pump inhibitor (PPI), 44.3% for voice therapy, 60.0% for surgical removal, and 74.2% for botulinum toxin injection. Voice therapy, PPI, and botulinum toxin had more good responses than simple observation for the long‐term outcome (P < 0.05). Surgical removal had a significantly higher recurrence rate (37.1%) than simple observation (10.3%) (P < 0.05).
Conclusions
Voice therapy or PPI are recommended as first‐line treatments. Surgical removal should be reserved for selected patients because of the high chance of recurrence. Botulinum toxin injection can be used not only for primary cases but also for refractory cases with an expected high response rate.
Level of Evidence
4. Laryngoscope, 124:1187–1191, 2014</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24307485</pmid><doi>10.1002/lary.24470</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 2014-05, Vol.124 (5), p.1187-1191 |
| issn | 0023-852X 1531-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1518623076 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Contact granuloma Disease Progression Drug therapy Female Granuloma - therapy Humans Laryngeal Diseases - therapy Laryngoscopy Male Medical research Middle Aged Recurrence Republic of Korea Retrospective Studies therapeutic treatment guideline Treatment Outcome |
| title | Comparison of treatment modalities for Contact granuloma: A Nationwide Multicenter Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T11%3A36%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20treatment%20modalities%20for%20Contact%20granuloma:%20A%20Nationwide%20Multicenter%20Study&rft.jtitle=The%20Laryngoscope&rft.au=Lee,%20Seung%20Won&rft.date=2014-05&rft.volume=124&rft.issue=5&rft.spage=1187&rft.epage=1191&rft.pages=1187-1191&rft.issn=0023-852X&rft.eissn=1531-4995&rft_id=info:doi/10.1002/lary.24470&rft_dat=%3Cproquest_cross%3E1518623076%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1517547746&rft_id=info:pmid/24307485&rfr_iscdi=true |