rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype
SCOPE: Carnosic acid (CA) and rosemary extracts (REs) have antiobesity effects but the mechanisms are not understood. We investigated some of the potential mechanisms contributing to the metabolic effects of an RE enriched in CA. METHODS AND RESULTS: An RE (∼40% CA) was administered to lean (Le, fa/...
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| Veröffentlicht in: | Molecular nutrition & food research 2014-05, Vol.58 (5), p.942-953 |
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| creator | Romo‐Vaquero, María Larrosa, Mar Yáñez‐Gascón, María J Issaly, Nicolas Flanagan, John Roller, Marc Tomás‐Barberán, Francisco A Espín, Juan C García‐Conesa, María‐Teresa |
| description | SCOPE: Carnosic acid (CA) and rosemary extracts (REs) have antiobesity effects but the mechanisms are not understood. We investigated some of the potential mechanisms contributing to the metabolic effects of an RE enriched in CA. METHODS AND RESULTS: An RE (∼40% CA) was administered to lean (Le, fa/+) and obese (Ob, fa/fa) female Zucker rats for 64 days. Several adipocytokines, brain‐derived neurotrophic factor, phosphorylated AMP‐activated protein kinase, and hepatic gene expression changes were investigated. The RE significantly decreased circulating tumor necrosis factor alpha (RE/CT = 0.36, p < 0.0003), IL‐1β (0.48, p < 0.032), and leptin (0.48, p < 0.002), and upregulated adiponectin (1.47, p < 0.045) in the Le rats. The RE also induced phase I and phase II gene expression and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha. Notably, the RE decreased adipose phosphorylated AMP‐activated protein kinase and did not affect hepatic peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha in the Ob rats. CONCLUSION: Our results show that an RE rich in CA exerts anti‐inflammatory effects and affects hepatic metabolism in normal Le rats. We report significant differences in the expression and regulation of key metabolic sensors between Le and Ob rats that may contribute to explain the different ability of the two genotypes to respond to the RE. |
| doi_str_mv | 10.1002/mnfr.201300524 |
| format | Article |
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We investigated some of the potential mechanisms contributing to the metabolic effects of an RE enriched in CA. METHODS AND RESULTS: An RE (∼40% CA) was administered to lean (Le, fa/+) and obese (Ob, fa/fa) female Zucker rats for 64 days. Several adipocytokines, brain‐derived neurotrophic factor, phosphorylated AMP‐activated protein kinase, and hepatic gene expression changes were investigated. The RE significantly decreased circulating tumor necrosis factor alpha (RE/CT = 0.36, p < 0.0003), IL‐1β (0.48, p < 0.032), and leptin (0.48, p < 0.002), and upregulated adiponectin (1.47, p < 0.045) in the Le rats. The RE also induced phase I and phase II gene expression and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha. Notably, the RE decreased adipose phosphorylated AMP‐activated protein kinase and did not affect hepatic peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha in the Ob rats. CONCLUSION: Our results show that an RE rich in CA exerts anti‐inflammatory effects and affects hepatic metabolism in normal Le rats. We report significant differences in the expression and regulation of key metabolic sensors between Le and Ob rats that may contribute to explain the different ability of the two genotypes to respond to the RE.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201300524</identifier><identifier>PMID: 24550204</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA</publisher><subject>Adiponectin ; Adiponectin - genetics ; Adiponectin - metabolism ; AMP-Activated Protein Kinases - genetics ; AMP-Activated Protein Kinases - metabolism ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Obesity Agents - pharmacology ; Biological and medical sciences ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Diterpenes, Abietane - pharmacology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; gene expression ; gene expression regulation ; Genotype ; IL-1β ; interleukin-1 ; Interleukin-1beta - genetics ; Interleukin-1beta - metabolism ; Leptin ; Leptin - genetics ; Leptin - metabolism ; Liver - drug effects ; Liver - metabolism ; Medical sciences ; Metabolic diseases ; metabolism ; Obesity ; Obesity - drug therapy ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Phosphorylated AMP-activated protein kinase ; Plant Extracts - pharmacology ; protein kinases ; Rats ; Rats, Zucker ; rosemary ; Rosmarinus - chemistry ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Tumor necrosis factor alpha ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism ; Up-Regulation ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Molecular nutrition & food research, 2014-05, Vol.58 (5), p.942-953</ispartof><rights>2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 INIST-CNRS</rights><rights>2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4322-4fd5fbbcaa8f788ac0833a2dbe5203bed2b088ef1e524bb4eb46cb0bf8cbac273</citedby><cites>FETCH-LOGICAL-c4322-4fd5fbbcaa8f788ac0833a2dbe5203bed2b088ef1e524bb4eb46cb0bf8cbac273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201300524$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201300524$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28427300$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24550204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romo‐Vaquero, María</creatorcontrib><creatorcontrib>Larrosa, Mar</creatorcontrib><creatorcontrib>Yáñez‐Gascón, María J</creatorcontrib><creatorcontrib>Issaly, Nicolas</creatorcontrib><creatorcontrib>Flanagan, John</creatorcontrib><creatorcontrib>Roller, Marc</creatorcontrib><creatorcontrib>Tomás‐Barberán, Francisco A</creatorcontrib><creatorcontrib>Espín, Juan C</creatorcontrib><creatorcontrib>García‐Conesa, María‐Teresa</creatorcontrib><title>rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype</title><title>Molecular nutrition & food research</title><addtitle>Mol. Nutr. Food Res</addtitle><description>SCOPE: Carnosic acid (CA) and rosemary extracts (REs) have antiobesity effects but the mechanisms are not understood. We investigated some of the potential mechanisms contributing to the metabolic effects of an RE enriched in CA. METHODS AND RESULTS: An RE (∼40% CA) was administered to lean (Le, fa/+) and obese (Ob, fa/fa) female Zucker rats for 64 days. Several adipocytokines, brain‐derived neurotrophic factor, phosphorylated AMP‐activated protein kinase, and hepatic gene expression changes were investigated. The RE significantly decreased circulating tumor necrosis factor alpha (RE/CT = 0.36, p < 0.0003), IL‐1β (0.48, p < 0.032), and leptin (0.48, p < 0.002), and upregulated adiponectin (1.47, p < 0.045) in the Le rats. The RE also induced phase I and phase II gene expression and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha. Notably, the RE decreased adipose phosphorylated AMP‐activated protein kinase and did not affect hepatic peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha in the Ob rats. CONCLUSION: Our results show that an RE rich in CA exerts anti‐inflammatory effects and affects hepatic metabolism in normal Le rats. We report significant differences in the expression and regulation of key metabolic sensors between Le and Ob rats that may contribute to explain the different ability of the two genotypes to respond to the RE.</description><subject>Adiponectin</subject><subject>Adiponectin - genetics</subject><subject>Adiponectin - metabolism</subject><subject>AMP-Activated Protein Kinases - genetics</subject><subject>AMP-Activated Protein Kinases - metabolism</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Diterpenes, Abietane - pharmacology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gene expression</subject><subject>gene expression regulation</subject><subject>Genotype</subject><subject>IL-1β</subject><subject>interleukin-1</subject><subject>Interleukin-1beta - genetics</subject><subject>Interleukin-1beta - metabolism</subject><subject>Leptin</subject><subject>Leptin - genetics</subject><subject>Leptin - metabolism</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>metabolism</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha</subject><subject>Phosphorylated AMP-activated protein kinase</subject><subject>Plant Extracts - pharmacology</subject><subject>protein kinases</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>rosemary</subject><subject>Rosmarinus - chemistry</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Tumor necrosis factor alpha</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Up-Regulation</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhUcIREthyxK8QWKT4NckI3Y0Ii0QigRUSN1Y157r1GTGDrYDzd_jl-FJQljijV_fOffq3Kp6yuiYUcpf9d7GMadMUFpzea86ZRMmRpIJcf945vVJ9Sil75QKxqV4WJ1wWdeUU3la_Y4hYQ9xS_AuRzCZoI_O3GJLnCcGog_JGQLGlYd-HcNPTMS4aDYdZOeXBFq3Dmabw8r58gW-JX1oh99yW-GW9JhBh66YJPQpxDQYdwie3GzMCiOJkNNrMosuOwPdzsEEX5pJuwKtsxYjeoM7Zb5FEjQmJEv0IW_X-Lh6YKFL-OSwn1XX87dfZ5ejxaeLd7M3i5GRgvORtG1ttTYAjZ02DRjaCAG81VhzKjS2XNOmQcvKXWotUcuJ0VTbxmgwfCrOqpd735LCjw2mrHqXDHYdeAybpFjNmgkvixZ0vEdNiTdFtGod3ZCyYlQNc1PD3NRxbkXw7OC90T22R_zvoArw4gBAKinZCN649I9rZOmQDpXlnvvlOtz-p6z6eDX_zJngRTbay1zKeHeUQVypyVRMa_Xt6kKdz-r388WHS3VT-Od73kJQsIyllesvxVdSSqclWCr-AOUIz-M</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Romo‐Vaquero, María</creator><creator>Larrosa, Mar</creator><creator>Yáñez‐Gascón, María J</creator><creator>Issaly, Nicolas</creator><creator>Flanagan, John</creator><creator>Roller, Marc</creator><creator>Tomás‐Barberán, Francisco A</creator><creator>Espín, Juan C</creator><creator>García‐Conesa, María‐Teresa</creator><general>Wiley-VCH Verlag GmbH & Co. KGaA</general><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype</title><author>Romo‐Vaquero, María ; Larrosa, Mar ; Yáñez‐Gascón, María J ; Issaly, Nicolas ; Flanagan, John ; Roller, Marc ; Tomás‐Barberán, Francisco A ; Espín, Juan C ; García‐Conesa, María‐Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4322-4fd5fbbcaa8f788ac0833a2dbe5203bed2b088ef1e524bb4eb46cb0bf8cbac273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adiponectin</topic><topic>Adiponectin - genetics</topic><topic>Adiponectin - metabolism</topic><topic>AMP-Activated Protein Kinases - genetics</topic><topic>AMP-Activated Protein Kinases - metabolism</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Diterpenes, Abietane - pharmacology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gene expression</topic><topic>gene expression regulation</topic><topic>Genotype</topic><topic>IL-1β</topic><topic>interleukin-1</topic><topic>Interleukin-1beta - genetics</topic><topic>Interleukin-1beta - metabolism</topic><topic>Leptin</topic><topic>Leptin - genetics</topic><topic>Leptin - metabolism</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>metabolism</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha</topic><topic>Phosphorylated AMP-activated protein kinase</topic><topic>Plant Extracts - pharmacology</topic><topic>protein kinases</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>rosemary</topic><topic>Rosmarinus - chemistry</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Tumor necrosis factor alpha</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Up-Regulation</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romo‐Vaquero, María</creatorcontrib><creatorcontrib>Larrosa, Mar</creatorcontrib><creatorcontrib>Yáñez‐Gascón, María J</creatorcontrib><creatorcontrib>Issaly, Nicolas</creatorcontrib><creatorcontrib>Flanagan, John</creatorcontrib><creatorcontrib>Roller, Marc</creatorcontrib><creatorcontrib>Tomás‐Barberán, Francisco A</creatorcontrib><creatorcontrib>Espín, Juan C</creatorcontrib><creatorcontrib>García‐Conesa, María‐Teresa</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romo‐Vaquero, María</au><au>Larrosa, Mar</au><au>Yáñez‐Gascón, María J</au><au>Issaly, Nicolas</au><au>Flanagan, John</au><au>Roller, Marc</au><au>Tomás‐Barberán, Francisco A</au><au>Espín, Juan C</au><au>García‐Conesa, María‐Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol. Nutr. Food Res</addtitle><date>2014-05</date><risdate>2014</risdate><volume>58</volume><issue>5</issue><spage>942</spage><epage>953</epage><pages>942-953</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>SCOPE: Carnosic acid (CA) and rosemary extracts (REs) have antiobesity effects but the mechanisms are not understood. We investigated some of the potential mechanisms contributing to the metabolic effects of an RE enriched in CA. METHODS AND RESULTS: An RE (∼40% CA) was administered to lean (Le, fa/+) and obese (Ob, fa/fa) female Zucker rats for 64 days. Several adipocytokines, brain‐derived neurotrophic factor, phosphorylated AMP‐activated protein kinase, and hepatic gene expression changes were investigated. The RE significantly decreased circulating tumor necrosis factor alpha (RE/CT = 0.36, p < 0.0003), IL‐1β (0.48, p < 0.032), and leptin (0.48, p < 0.002), and upregulated adiponectin (1.47, p < 0.045) in the Le rats. The RE also induced phase I and phase II gene expression and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha. Notably, the RE decreased adipose phosphorylated AMP‐activated protein kinase and did not affect hepatic peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha in the Ob rats. CONCLUSION: Our results show that an RE rich in CA exerts anti‐inflammatory effects and affects hepatic metabolism in normal Le rats. We report significant differences in the expression and regulation of key metabolic sensors between Le and Ob rats that may contribute to explain the different ability of the two genotypes to respond to the RE.</abstract><cop>Weinheim</cop><pub>Wiley-VCH Verlag GmbH & Co. KGaA</pub><pmid>24550204</pmid><doi>10.1002/mnfr.201300524</doi><tpages>12</tpages></addata></record> |
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| subjects | Adiponectin Adiponectin - genetics Adiponectin - metabolism AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Anti-Inflammatory Agents - pharmacology Anti-Obesity Agents - pharmacology Biological and medical sciences Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Diterpenes, Abietane - pharmacology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology gene expression gene expression regulation Genotype IL-1β interleukin-1 Interleukin-1beta - genetics Interleukin-1beta - metabolism Leptin Leptin - genetics Leptin - metabolism Liver - drug effects Liver - metabolism Medical sciences Metabolic diseases metabolism Obesity Obesity - drug therapy Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Phosphorylated AMP-activated protein kinase Plant Extracts - pharmacology protein kinases Rats Rats, Zucker rosemary Rosmarinus - chemistry Transcription Factors - genetics Transcription Factors - metabolism Tumor necrosis factor alpha Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Up-Regulation Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype |
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