Biocompatibility assessment of porous chitosan-Nafion and chitosan-PTFE composites in vivo
Chitosan (CS) is widely used as a scaffold material in tissue engineering. The objective of this study was to test whether porous chitosan membrane (PCSM) coating for Nafion used in implantable sensor reduced fibrous capsule (FC) density and promoted superior vascularization compared with PCSM coati...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2014-06, Vol.102 (6), p.2055-2060 |
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| creator | Liu, Bo-Ji Ma, Li-Nan Su, Juan Jing, Wei-Wei Wei, Min-Jie Sha, Xian-Zheng |
| description | Chitosan (CS) is widely used as a scaffold material in tissue engineering. The objective of this study was to test whether porous chitosan membrane (PCSM) coating for Nafion used in implantable sensor reduced fibrous capsule (FC) density and promoted superior vascularization compared with PCSM coating for polytetrafluoroethylene (PTFE). PCSM was fabricated with solvent casting/particulate leaching method using silica gel as porogen and characterized in vitro. Then, PCSM‐Nafion and PCSM‐PTFE composites were assembled with hydrated PCSM and implanted subcutaneously in rats. The histological analysis was performed in comparison with Nafion and PTFE. Implants were explanted 35, 65, and 100 days after the implantation. Histological assessments indicated that both composites achieved presumed effects of porous coatings on decreasing collagen deposition and promoting angiogenesis. PCSM‐PTFE exerted higher collagen deposition by area ratio, both within and outside, compared with that of PCSM‐Nafion. Angiogenesis within and outside the PCSM‐Nafion both increased over time, but that of the PCSM‐PTFE within decreased. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2055–2060, 2014. |
| doi_str_mv | 10.1002/jbm.a.34830 |
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The objective of this study was to test whether porous chitosan membrane (PCSM) coating for Nafion used in implantable sensor reduced fibrous capsule (FC) density and promoted superior vascularization compared with PCSM coating for polytetrafluoroethylene (PTFE). PCSM was fabricated with solvent casting/particulate leaching method using silica gel as porogen and characterized in vitro. Then, PCSM‐Nafion and PCSM‐PTFE composites were assembled with hydrated PCSM and implanted subcutaneously in rats. The histological analysis was performed in comparison with Nafion and PTFE. Implants were explanted 35, 65, and 100 days after the implantation. Histological assessments indicated that both composites achieved presumed effects of porous coatings on decreasing collagen deposition and promoting angiogenesis. PCSM‐PTFE exerted higher collagen deposition by area ratio, both within and outside, compared with that of PCSM‐Nafion. Angiogenesis within and outside the PCSM‐Nafion both increased over time, but that of the PCSM‐PTFE within decreased. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2055–2060, 2014.</description><identifier>ISSN: 1549-3296</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.34830</identifier><identifier>PMID: 23765695</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Animals ; biocompatibility ; Biocompatible Materials - adverse effects ; Biocompatible Materials - chemistry ; Biological and medical sciences ; chitosan ; Chitosan - adverse effects ; Chitosan - chemistry ; Fluorocarbon Polymers - chemistry ; foreign body response ; Foreign-Body Reaction - etiology ; Foreign-Body Reaction - pathology ; implantable sensor ; Medical sciences ; Polytetrafluoroethylene - adverse effects ; Polytetrafluoroethylene - chemistry ; Porosity ; porous composite ; Rats ; Rats, Sprague-Dawley ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Tissue Scaffolds - adverse effects ; Tissue Scaffolds - chemistry</subject><ispartof>Journal of biomedical materials research. 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Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Chitosan (CS) is widely used as a scaffold material in tissue engineering. The objective of this study was to test whether porous chitosan membrane (PCSM) coating for Nafion used in implantable sensor reduced fibrous capsule (FC) density and promoted superior vascularization compared with PCSM coating for polytetrafluoroethylene (PTFE). PCSM was fabricated with solvent casting/particulate leaching method using silica gel as porogen and characterized in vitro. Then, PCSM‐Nafion and PCSM‐PTFE composites were assembled with hydrated PCSM and implanted subcutaneously in rats. The histological analysis was performed in comparison with Nafion and PTFE. Implants were explanted 35, 65, and 100 days after the implantation. Histological assessments indicated that both composites achieved presumed effects of porous coatings on decreasing collagen deposition and promoting angiogenesis. PCSM‐PTFE exerted higher collagen deposition by area ratio, both within and outside, compared with that of PCSM‐Nafion. Angiogenesis within and outside the PCSM‐Nafion both increased over time, but that of the PCSM‐PTFE within decreased. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2055–2060, 2014.</description><subject>Animals</subject><subject>biocompatibility</subject><subject>Biocompatible Materials - adverse effects</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological and medical sciences</subject><subject>chitosan</subject><subject>Chitosan - adverse effects</subject><subject>Chitosan - chemistry</subject><subject>Fluorocarbon Polymers - chemistry</subject><subject>foreign body response</subject><subject>Foreign-Body Reaction - etiology</subject><subject>Foreign-Body Reaction - pathology</subject><subject>implantable sensor</subject><subject>Medical sciences</subject><subject>Polytetrafluoroethylene - adverse effects</subject><subject>Polytetrafluoroethylene - chemistry</subject><subject>Porosity</subject><subject>porous composite</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. 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Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Bo-Ji</au><au>Ma, Li-Nan</au><au>Su, Juan</au><au>Jing, Wei-Wei</au><au>Wei, Min-Jie</au><au>Sha, Xian-Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatibility assessment of porous chitosan-Nafion and chitosan-PTFE composites in vivo</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2014-06</date><risdate>2014</risdate><volume>102</volume><issue>6</issue><spage>2055</spage><epage>2060</epage><pages>2055-2060</pages><issn>1549-3296</issn><eissn>1552-4965</eissn><abstract>Chitosan (CS) is widely used as a scaffold material in tissue engineering. The objective of this study was to test whether porous chitosan membrane (PCSM) coating for Nafion used in implantable sensor reduced fibrous capsule (FC) density and promoted superior vascularization compared with PCSM coating for polytetrafluoroethylene (PTFE). PCSM was fabricated with solvent casting/particulate leaching method using silica gel as porogen and characterized in vitro. Then, PCSM‐Nafion and PCSM‐PTFE composites were assembled with hydrated PCSM and implanted subcutaneously in rats. The histological analysis was performed in comparison with Nafion and PTFE. Implants were explanted 35, 65, and 100 days after the implantation. Histological assessments indicated that both composites achieved presumed effects of porous coatings on decreasing collagen deposition and promoting angiogenesis. PCSM‐PTFE exerted higher collagen deposition by area ratio, both within and outside, compared with that of PCSM‐Nafion. Angiogenesis within and outside the PCSM‐Nafion both increased over time, but that of the PCSM‐PTFE within decreased. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2055–2060, 2014.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>23765695</pmid><doi>10.1002/jbm.a.34830</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals biocompatibility Biocompatible Materials - adverse effects Biocompatible Materials - chemistry Biological and medical sciences chitosan Chitosan - adverse effects Chitosan - chemistry Fluorocarbon Polymers - chemistry foreign body response Foreign-Body Reaction - etiology Foreign-Body Reaction - pathology implantable sensor Medical sciences Polytetrafluoroethylene - adverse effects Polytetrafluoroethylene - chemistry Porosity porous composite Rats Rats, Sprague-Dawley Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tissue Scaffolds - adverse effects Tissue Scaffolds - chemistry |
| title | Biocompatibility assessment of porous chitosan-Nafion and chitosan-PTFE composites in vivo |
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