Endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors in Japan: Multicenter case series
Background and Aim To verify the current status in Japan on endoscopic diagnosis of superficial non‐ampullary duodenal epithelial tumors (SNADET) by a multicenter case series through a questionnaire survey. Methods Nine endoscopists and a surgeon responded to a questionnaire on endoscopic diagnosis...
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| Veröffentlicht in: | Digestive endoscopy 2014-04, Vol.26 (S2), p.23-29 |
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| container_title | Digestive endoscopy |
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| creator | Goda, Kenichi Kikuchi, Daisuke Yamamoto, Yorimasa Takimoto, Kengo Kakushima, Naomi Morita, Yoshinori Doyama, Hisashi Gotoda, Takuji Maehata, Yuji Abe, Noritsugu |
| description | Background and Aim
To verify the current status in Japan on endoscopic diagnosis of superficial non‐ampullary duodenal epithelial tumors (SNADET) by a multicenter case series through a questionnaire survey.
Methods
Nine endoscopists and a surgeon responded to a questionnaire on endoscopic diagnosis of SNADET. The subjects of this survey were histologically confirmed SNADET that were endoscopically or surgically resected from 2007 to 2012. This survey collected data of 364 patients with 396 SNADET.
Results
Of the 396 SNADET, 121 were histologically diagnosed as low‐grade dysplasia (LGD), 112 as high‐grade dysplasia (HGD), and 163 as superficial adenocarcinoma (SAC) including 153 mucosal carcinomas and 10 submucosal carcinomas. Total number of SNADET increased from 125 in the first half to 271 in the second half of the survey period. Compared to LGD, a significantly greater number of HGD or SAC was found in the tumors having a diameter >5 mm as well as solitary or predominantly red color. Preoperative endoscopic diagnosis indicated significantly higher sensitivity and accuracy and significantly lower specificity for HGD or SAC of final histology than preoperative biopsy. Ten submucosal carcinomas had 0‐I or 0‐IIa+IIc macroscopic‐type tumors with red color.
Conclusions
This multicenter case series study suggested that the number of resected SNADET is dramatically increasing in Japan. Tumor diameter >5 mm and red color seemed to be signs for tumors of HGD or SAC. Preoperative endoscopy may provide a more reliable diagnosis of final histology of HGD or SAC than preoperative biopsy. Further studies are warranted for establishing endoscopic features of submucosal carcinoma. |
| doi_str_mv | 10.1111/den.12277 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1518618468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1518618468</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3557-e16a42cd082bdaec6044e352b4922bce60b1e47f3865018b2b750466118bc9503</originalsourceid><addsrcrecordid>eNo9kM1SwyAURhlHR2t14Qs4LN3EAgGSutNaqx1_NlqXDCG3iiYQQzLat5dalQ134Hww50PoiJJTGteoBHdKGcuyLTSgnKcJlZJuowEZU5EImYo9tB_CGyGUjTnfRXuMZ4JEcoDc1JU-GN9Yg0urX5wPNmC_xKFvoF1aY3WFnXeJrpu-qnS7wmXv44fxGBrbvUK1Jrq-9m3A1uG5brQ7w3d91VkDroMWGx0AB2gthAO0s9RVgMPffYierqaPk-vk9mF2Mzm_TWwqRJYAlZozU5KcFaUGIwnnkApW8DFjhQFJCgo8W6a5jB55wYrow6N0nM1YkHSITjbvNq3_6CF0qrbBQBRw4PugqKC5pDmXeUSPf9G-qKFUTWvrqKn-OorAaAN82gpW__eUqHX5KnahfspXl9P7nyEmkk3Chg6-_hO6fVcySzOhnu9n6oLdLcTlfK4W6TdhioZ5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1518618468</pqid></control><display><type>article</type><title>Endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors in Japan: Multicenter case series</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Goda, Kenichi ; Kikuchi, Daisuke ; Yamamoto, Yorimasa ; Takimoto, Kengo ; Kakushima, Naomi ; Morita, Yoshinori ; Doyama, Hisashi ; Gotoda, Takuji ; Maehata, Yuji ; Abe, Noritsugu</creator><creatorcontrib>Goda, Kenichi ; Kikuchi, Daisuke ; Yamamoto, Yorimasa ; Takimoto, Kengo ; Kakushima, Naomi ; Morita, Yoshinori ; Doyama, Hisashi ; Gotoda, Takuji ; Maehata, Yuji ; Abe, Noritsugu</creatorcontrib><description>Background and Aim
To verify the current status in Japan on endoscopic diagnosis of superficial non‐ampullary duodenal epithelial tumors (SNADET) by a multicenter case series through a questionnaire survey.
Methods
Nine endoscopists and a surgeon responded to a questionnaire on endoscopic diagnosis of SNADET. The subjects of this survey were histologically confirmed SNADET that were endoscopically or surgically resected from 2007 to 2012. This survey collected data of 364 patients with 396 SNADET.
Results
Of the 396 SNADET, 121 were histologically diagnosed as low‐grade dysplasia (LGD), 112 as high‐grade dysplasia (HGD), and 163 as superficial adenocarcinoma (SAC) including 153 mucosal carcinomas and 10 submucosal carcinomas. Total number of SNADET increased from 125 in the first half to 271 in the second half of the survey period. Compared to LGD, a significantly greater number of HGD or SAC was found in the tumors having a diameter >5 mm as well as solitary or predominantly red color. Preoperative endoscopic diagnosis indicated significantly higher sensitivity and accuracy and significantly lower specificity for HGD or SAC of final histology than preoperative biopsy. Ten submucosal carcinomas had 0‐I or 0‐IIa+IIc macroscopic‐type tumors with red color.
Conclusions
This multicenter case series study suggested that the number of resected SNADET is dramatically increasing in Japan. Tumor diameter >5 mm and red color seemed to be signs for tumors of HGD or SAC. Preoperative endoscopy may provide a more reliable diagnosis of final histology of HGD or SAC than preoperative biopsy. Further studies are warranted for establishing endoscopic features of submucosal carcinoma.</description><identifier>ISSN: 0915-5635</identifier><identifier>EISSN: 1443-1661</identifier><identifier>DOI: 10.1111/den.12277</identifier><identifier>PMID: 24750144</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; adenoma ; Aged ; Ampulla of Vater ; Biopsy, Needle ; carcinoma ; Carcinoma - diagnosis ; Carcinoma - pathology ; Carcinoma - surgery ; Cohort Studies ; Cross-Sectional Studies ; Diagnosis, Differential ; duodenal cancer ; Duodenal Neoplasms - diagnosis ; Duodenal Neoplasms - pathology ; Duodenal Neoplasms - surgery ; Duodenoscopy - methods ; endoscopic diagnosis ; Endoscopy - methods ; Female ; Humans ; Immunohistochemistry ; Intestinal Mucosa - pathology ; Japan ; Male ; Middle Aged ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; non-ampullary tumor ; Retrospective Studies ; Risk Assessment ; Statistics, Nonparametric ; Surveys and Questionnaires</subject><ispartof>Digestive endoscopy, 2014-04, Vol.26 (S2), p.23-29</ispartof><rights>2014 The Authors. Digestive Endoscopy © 2014 Japan Gastroenterological Endoscopy Society</rights><rights>2014 The Authors. Digestive Endoscopy © 2014 Japan Gastroenterological Endoscopy Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fden.12277$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fden.12277$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24750144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goda, Kenichi</creatorcontrib><creatorcontrib>Kikuchi, Daisuke</creatorcontrib><creatorcontrib>Yamamoto, Yorimasa</creatorcontrib><creatorcontrib>Takimoto, Kengo</creatorcontrib><creatorcontrib>Kakushima, Naomi</creatorcontrib><creatorcontrib>Morita, Yoshinori</creatorcontrib><creatorcontrib>Doyama, Hisashi</creatorcontrib><creatorcontrib>Gotoda, Takuji</creatorcontrib><creatorcontrib>Maehata, Yuji</creatorcontrib><creatorcontrib>Abe, Noritsugu</creatorcontrib><title>Endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors in Japan: Multicenter case series</title><title>Digestive endoscopy</title><addtitle>Digestive Endoscopy</addtitle><description>Background and Aim
To verify the current status in Japan on endoscopic diagnosis of superficial non‐ampullary duodenal epithelial tumors (SNADET) by a multicenter case series through a questionnaire survey.
Methods
Nine endoscopists and a surgeon responded to a questionnaire on endoscopic diagnosis of SNADET. The subjects of this survey were histologically confirmed SNADET that were endoscopically or surgically resected from 2007 to 2012. This survey collected data of 364 patients with 396 SNADET.
Results
Of the 396 SNADET, 121 were histologically diagnosed as low‐grade dysplasia (LGD), 112 as high‐grade dysplasia (HGD), and 163 as superficial adenocarcinoma (SAC) including 153 mucosal carcinomas and 10 submucosal carcinomas. Total number of SNADET increased from 125 in the first half to 271 in the second half of the survey period. Compared to LGD, a significantly greater number of HGD or SAC was found in the tumors having a diameter >5 mm as well as solitary or predominantly red color. Preoperative endoscopic diagnosis indicated significantly higher sensitivity and accuracy and significantly lower specificity for HGD or SAC of final histology than preoperative biopsy. Ten submucosal carcinomas had 0‐I or 0‐IIa+IIc macroscopic‐type tumors with red color.
Conclusions
This multicenter case series study suggested that the number of resected SNADET is dramatically increasing in Japan. Tumor diameter >5 mm and red color seemed to be signs for tumors of HGD or SAC. Preoperative endoscopy may provide a more reliable diagnosis of final histology of HGD or SAC than preoperative biopsy. Further studies are warranted for establishing endoscopic features of submucosal carcinoma.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>adenoma</subject><subject>Aged</subject><subject>Ampulla of Vater</subject><subject>Biopsy, Needle</subject><subject>carcinoma</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diagnosis, Differential</subject><subject>duodenal cancer</subject><subject>Duodenal Neoplasms - diagnosis</subject><subject>Duodenal Neoplasms - pathology</subject><subject>Duodenal Neoplasms - surgery</subject><subject>Duodenoscopy - methods</subject><subject>endoscopic diagnosis</subject><subject>Endoscopy - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intestinal Mucosa - pathology</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>non-ampullary tumor</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Statistics, Nonparametric</subject><subject>Surveys and Questionnaires</subject><issn>0915-5635</issn><issn>1443-1661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1SwyAURhlHR2t14Qs4LN3EAgGSutNaqx1_NlqXDCG3iiYQQzLat5dalQ134Hww50PoiJJTGteoBHdKGcuyLTSgnKcJlZJuowEZU5EImYo9tB_CGyGUjTnfRXuMZ4JEcoDc1JU-GN9Yg0urX5wPNmC_xKFvoF1aY3WFnXeJrpu-qnS7wmXv44fxGBrbvUK1Jrq-9m3A1uG5brQ7w3d91VkDroMWGx0AB2gthAO0s9RVgMPffYierqaPk-vk9mF2Mzm_TWwqRJYAlZozU5KcFaUGIwnnkApW8DFjhQFJCgo8W6a5jB55wYrow6N0nM1YkHSITjbvNq3_6CF0qrbBQBRw4PugqKC5pDmXeUSPf9G-qKFUTWvrqKn-OorAaAN82gpW__eUqHX5KnahfspXl9P7nyEmkk3Chg6-_hO6fVcySzOhnu9n6oLdLcTlfK4W6TdhioZ5</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Goda, Kenichi</creator><creator>Kikuchi, Daisuke</creator><creator>Yamamoto, Yorimasa</creator><creator>Takimoto, Kengo</creator><creator>Kakushima, Naomi</creator><creator>Morita, Yoshinori</creator><creator>Doyama, Hisashi</creator><creator>Gotoda, Takuji</creator><creator>Maehata, Yuji</creator><creator>Abe, Noritsugu</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors in Japan: Multicenter case series</title><author>Goda, Kenichi ; Kikuchi, Daisuke ; Yamamoto, Yorimasa ; Takimoto, Kengo ; Kakushima, Naomi ; Morita, Yoshinori ; Doyama, Hisashi ; Gotoda, Takuji ; Maehata, Yuji ; Abe, Noritsugu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3557-e16a42cd082bdaec6044e352b4922bce60b1e47f3865018b2b750466118bc9503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>adenoma</topic><topic>Aged</topic><topic>Ampulla of Vater</topic><topic>Biopsy, Needle</topic><topic>carcinoma</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diagnosis, Differential</topic><topic>duodenal cancer</topic><topic>Duodenal Neoplasms - diagnosis</topic><topic>Duodenal Neoplasms - pathology</topic><topic>Duodenal Neoplasms - surgery</topic><topic>Duodenoscopy - methods</topic><topic>endoscopic diagnosis</topic><topic>Endoscopy - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intestinal Mucosa - pathology</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>non-ampullary tumor</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Statistics, Nonparametric</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goda, Kenichi</creatorcontrib><creatorcontrib>Kikuchi, Daisuke</creatorcontrib><creatorcontrib>Yamamoto, Yorimasa</creatorcontrib><creatorcontrib>Takimoto, Kengo</creatorcontrib><creatorcontrib>Kakushima, Naomi</creatorcontrib><creatorcontrib>Morita, Yoshinori</creatorcontrib><creatorcontrib>Doyama, Hisashi</creatorcontrib><creatorcontrib>Gotoda, Takuji</creatorcontrib><creatorcontrib>Maehata, Yuji</creatorcontrib><creatorcontrib>Abe, Noritsugu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goda, Kenichi</au><au>Kikuchi, Daisuke</au><au>Yamamoto, Yorimasa</au><au>Takimoto, Kengo</au><au>Kakushima, Naomi</au><au>Morita, Yoshinori</au><au>Doyama, Hisashi</au><au>Gotoda, Takuji</au><au>Maehata, Yuji</au><au>Abe, Noritsugu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors in Japan: Multicenter case series</atitle><jtitle>Digestive endoscopy</jtitle><addtitle>Digestive Endoscopy</addtitle><date>2014-04</date><risdate>2014</risdate><volume>26</volume><issue>S2</issue><spage>23</spage><epage>29</epage><pages>23-29</pages><issn>0915-5635</issn><eissn>1443-1661</eissn><abstract>Background and Aim
To verify the current status in Japan on endoscopic diagnosis of superficial non‐ampullary duodenal epithelial tumors (SNADET) by a multicenter case series through a questionnaire survey.
Methods
Nine endoscopists and a surgeon responded to a questionnaire on endoscopic diagnosis of SNADET. The subjects of this survey were histologically confirmed SNADET that were endoscopically or surgically resected from 2007 to 2012. This survey collected data of 364 patients with 396 SNADET.
Results
Of the 396 SNADET, 121 were histologically diagnosed as low‐grade dysplasia (LGD), 112 as high‐grade dysplasia (HGD), and 163 as superficial adenocarcinoma (SAC) including 153 mucosal carcinomas and 10 submucosal carcinomas. Total number of SNADET increased from 125 in the first half to 271 in the second half of the survey period. Compared to LGD, a significantly greater number of HGD or SAC was found in the tumors having a diameter >5 mm as well as solitary or predominantly red color. Preoperative endoscopic diagnosis indicated significantly higher sensitivity and accuracy and significantly lower specificity for HGD or SAC of final histology than preoperative biopsy. Ten submucosal carcinomas had 0‐I or 0‐IIa+IIc macroscopic‐type tumors with red color.
Conclusions
This multicenter case series study suggested that the number of resected SNADET is dramatically increasing in Japan. Tumor diameter >5 mm and red color seemed to be signs for tumors of HGD or SAC. Preoperative endoscopy may provide a more reliable diagnosis of final histology of HGD or SAC than preoperative biopsy. Further studies are warranted for establishing endoscopic features of submucosal carcinoma.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>24750144</pmid><doi>10.1111/den.12277</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - pathology Adenocarcinoma - surgery adenoma Aged Ampulla of Vater Biopsy, Needle carcinoma Carcinoma - diagnosis Carcinoma - pathology Carcinoma - surgery Cohort Studies Cross-Sectional Studies Diagnosis, Differential duodenal cancer Duodenal Neoplasms - diagnosis Duodenal Neoplasms - pathology Duodenal Neoplasms - surgery Duodenoscopy - methods endoscopic diagnosis Endoscopy - methods Female Humans Immunohistochemistry Intestinal Mucosa - pathology Japan Male Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging non-ampullary tumor Retrospective Studies Risk Assessment Statistics, Nonparametric Surveys and Questionnaires |
| title | Endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors in Japan: Multicenter case series |
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