Toll‐like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

The global health and economic burden of type 2 diabetes (T2D) has reached staggering proportions. Current projections estimate that 592 million people will have diabetes by 2035. T2D—which comprises 90% of cases—is a complex disease, in most cases resulting from a combination of predisposing genes...

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Veröffentlicht in:	Immunology and cell biology 2014-04, Vol.92 (4), p.314-323
Hauptverfasser:	Westwell‐Roper, Clara, Nackiewicz, Dominika, Dan, Meixia, Ehses, Jan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - therapy Humans inflammation Inflammation - immunology Inflammation - pathology Islets of Langerhans - immunology Islets of Langerhans - pathology macrophage Macrophages - pathology NLRP3 inflammasome pancreatic beta pancreatic islet Toll-Like Receptors - metabolism Toll‐like receptor
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