Synthesis of β-cyclodextrin modified chitosan–poly(acrylic acid) nanoparticles and use as drug carriers

► CS–PAACD NPs was obtained by introducing β-CD into CS–PAA nanoparticles. ► The size and the structure of CS–PAACD NPs can be controlled by varying the content of β-CD in them. ► These CS–PAACD NPs had a pH responsible property and excellent encapsulation ability to paclitaxel. ► These paclitaxel l...

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Veröffentlicht in:	Carbohydrate polymers 2012-09, Vol.90 (1), p.361-369
Hauptverfasser:	Wang, Xue, Chen, Changjing, Huo, Da, Qian, Hanqing, Ding, Yin, Hu, Yong, Jiang, Xiqun
Format:	Artikel
Sprache:	eng
Schlagworte:	acrylic acid Acrylic Resins - administration & dosage Acrylic Resins - chemical synthesis Applied sciences aqueous solutions atomic force microscopy beta-cyclodextrin beta-Cyclodextrins - administration & dosage beta-Cyclodextrins - chemical synthesis Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects Cell Survival - physiology Chitosan Chitosan - administration & dosage Chitosan - chemical synthesis Cyclodextrin drug carriers Drug Carriers - administration & dosage Drug Carriers - chemical synthesis drugs encapsulation Exact sciences and technology General pharmacology Humans hydrophobicity Medical sciences microstructure Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Natural polymers Paclitaxel Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers scanning electron microscopy solubility Starch and polysaccharides transmission electron microscopy
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