Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease
: Polyunsaturated fatty acid (PUFA) levels (an index of the amount of substrate available for lipid peroxidation) were measured in several brain regions from patients who died with Parkinson's disease and age‐matched control human postmortem brains. PUFA levels were reduced in parkinsonian subs...
Gespeichert in:
| Veröffentlicht in: | Journal of neurochemistry 1989-02, Vol.52 (2), p.381-389 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 389 |
|---|---|
| container_issue | 2 |
| container_start_page | 381 |
| container_title | Journal of neurochemistry |
| container_volume | 52 |
| creator | Dexter, D. T. Carter, C. J. Wells, F. R. Javoy‐Agid, F. Agid, Y. Lees, A. Jenner, P. Marsden, C. D. |
| description | : Polyunsaturated fatty acid (PUFA) levels (an index of the amount of substrate available for lipid peroxidation) were measured in several brain regions from patients who died with Parkinson's disease and age‐matched control human postmortem brains. PUFA levels were reduced in parkinsonian substantia nigra compared to other brain regions and to control tissue. However, basal malondialdehyde (MDA; an intermediate in the lipid peroxidation process) levels were increased in parkinsonian nigra compared with other parkinsonian brain regions and control tissue. Expressing basal MDA levels in terms of PUFA content, the difference between parkinsonian and control substantia nigra was even more pronounced. Stimulating MDA production by incubating tissue with FeSO4 plus ascorbic acid, FeSO4 plus H2O2, or air alone produced lower MDA levels in the parkinsonian substantia nigra, probably reflecting the lower PUFA content. These results may indicate that an increased level of lipid peroxidation continues to occur in the parkinsonian nigra up to the time of death, perhaps because of continued exposure to excess free radicals derived from some endogenous or exogenous neurotoxic species. |
| doi_str_mv | 10.1111/j.1471-4159.1989.tb09133.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15186070</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15186070</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4961-d053b83535666988cb20f953b7ce17c2fd49b549aa1a289cf02eeea3cf625b4b3</originalsourceid><addsrcrecordid>eNqVkE2L2zAQhkXZkmbT_oSCKWz3ZFcjyR_aQ6GbfqWENND2LMayXJR17FTjsNl_X5uY3fPORTDvMzPiYewd8ASG-rBLQOUQK0h1ArrQSV9yDVImpxds_hhdsDnnQsSSK_GKXRLtOIdMZTBjM6EBuJBztr1FwiZa-4Ovoq0L3clX2PuujXwb_TqW1GPbe4w2_m_AaEXRqrXBIblqBLYY7nxLXXtN0WdPY_81e1ljQ-7N9C7Yn69ffi-_x-uf31bLT-vYKp1BXPFUloVMZZplmS4KWwpe66GXWwe5FXWldJkqjQgoCm1rLpxzKG2dibRUpVyw9-e9h9D9Ozrqzd6TdU2DreuOZCCFIuM5H8CbM2hDRxRcbQ7B7zE8GOBm1Gl2ZnRmRmdm1GkmneY0DL-drhzLvaseRyd_Q3415UgWmzpgaz09XdApcJWP3Mczd-8b9_CMH5gfm6UsQP4Hnf2RNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15186070</pqid></control><display><type>article</type><title>Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Dexter, D. T. ; Carter, C. J. ; Wells, F. R. ; Javoy‐Agid, F. ; Agid, Y. ; Lees, A. ; Jenner, P. ; Marsden, C. D.</creator><creatorcontrib>Dexter, D. T. ; Carter, C. J. ; Wells, F. R. ; Javoy‐Agid, F. ; Agid, Y. ; Lees, A. ; Jenner, P. ; Marsden, C. D.</creatorcontrib><description>: Polyunsaturated fatty acid (PUFA) levels (an index of the amount of substrate available for lipid peroxidation) were measured in several brain regions from patients who died with Parkinson's disease and age‐matched control human postmortem brains. PUFA levels were reduced in parkinsonian substantia nigra compared to other brain regions and to control tissue. However, basal malondialdehyde (MDA; an intermediate in the lipid peroxidation process) levels were increased in parkinsonian nigra compared with other parkinsonian brain regions and control tissue. Expressing basal MDA levels in terms of PUFA content, the difference between parkinsonian and control substantia nigra was even more pronounced. Stimulating MDA production by incubating tissue with FeSO4 plus ascorbic acid, FeSO4 plus H2O2, or air alone produced lower MDA levels in the parkinsonian substantia nigra, probably reflecting the lower PUFA content. These results may indicate that an increased level of lipid peroxidation continues to occur in the parkinsonian nigra up to the time of death, perhaps because of continued exposure to excess free radicals derived from some endogenous or exogenous neurotoxic species.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1989.tb09133.x</identifier><identifier>PMID: 2911023</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Animals ; Ascorbic Acid - pharmacology ; Biological and medical sciences ; Brain - metabolism ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Fatty Acids, Unsaturated - metabolism ; Female ; Ferrous Compounds - pharmacology ; Free Radicals ; Humans ; Hydrogen Peroxide - pharmacology ; Lipid Peroxidation ; Male ; Malondialdehyde ; Malondialdehyde - metabolism ; man ; Medical sciences ; Neurology ; Parkinson Disease - metabolism ; Parkinson's disease ; Postmortem Changes ; Rats ; Rats, Inbred Strains ; Substantia nigra ; Substantia Nigra - drug effects ; Substantia Nigra - metabolism ; Thiobarbiturates</subject><ispartof>Journal of neurochemistry, 1989-02, Vol.52 (2), p.381-389</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4961-d053b83535666988cb20f953b7ce17c2fd49b549aa1a289cf02eeea3cf625b4b3</citedby><cites>FETCH-LOGICAL-c4961-d053b83535666988cb20f953b7ce17c2fd49b549aa1a289cf02eeea3cf625b4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1989.tb09133.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1989.tb09133.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19510473$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2911023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dexter, D. T.</creatorcontrib><creatorcontrib>Carter, C. J.</creatorcontrib><creatorcontrib>Wells, F. R.</creatorcontrib><creatorcontrib>Javoy‐Agid, F.</creatorcontrib><creatorcontrib>Agid, Y.</creatorcontrib><creatorcontrib>Lees, A.</creatorcontrib><creatorcontrib>Jenner, P.</creatorcontrib><creatorcontrib>Marsden, C. D.</creatorcontrib><title>Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Polyunsaturated fatty acid (PUFA) levels (an index of the amount of substrate available for lipid peroxidation) were measured in several brain regions from patients who died with Parkinson's disease and age‐matched control human postmortem brains. PUFA levels were reduced in parkinsonian substantia nigra compared to other brain regions and to control tissue. However, basal malondialdehyde (MDA; an intermediate in the lipid peroxidation process) levels were increased in parkinsonian nigra compared with other parkinsonian brain regions and control tissue. Expressing basal MDA levels in terms of PUFA content, the difference between parkinsonian and control substantia nigra was even more pronounced. Stimulating MDA production by incubating tissue with FeSO4 plus ascorbic acid, FeSO4 plus H2O2, or air alone produced lower MDA levels in the parkinsonian substantia nigra, probably reflecting the lower PUFA content. These results may indicate that an increased level of lipid peroxidation continues to occur in the parkinsonian nigra up to the time of death, perhaps because of continued exposure to excess free radicals derived from some endogenous or exogenous neurotoxic species.</description><subject>Aged</subject><subject>Animals</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Female</subject><subject>Ferrous Compounds - pharmacology</subject><subject>Free Radicals</subject><subject>Humans</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - metabolism</subject><subject>man</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson's disease</subject><subject>Postmortem Changes</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Substantia nigra</subject><subject>Substantia Nigra - drug effects</subject><subject>Substantia Nigra - metabolism</subject><subject>Thiobarbiturates</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE2L2zAQhkXZkmbT_oSCKWz3ZFcjyR_aQ6GbfqWENND2LMayXJR17FTjsNl_X5uY3fPORTDvMzPiYewd8ASG-rBLQOUQK0h1ArrQSV9yDVImpxds_hhdsDnnQsSSK_GKXRLtOIdMZTBjM6EBuJBztr1FwiZa-4Ovoq0L3clX2PuujXwb_TqW1GPbe4w2_m_AaEXRqrXBIblqBLYY7nxLXXtN0WdPY_81e1ljQ-7N9C7Yn69ffi-_x-uf31bLT-vYKp1BXPFUloVMZZplmS4KWwpe66GXWwe5FXWldJkqjQgoCm1rLpxzKG2dibRUpVyw9-e9h9D9Ozrqzd6TdU2DreuOZCCFIuM5H8CbM2hDRxRcbQ7B7zE8GOBm1Gl2ZnRmRmdm1GkmneY0DL-drhzLvaseRyd_Q3415UgWmzpgaz09XdApcJWP3Mczd-8b9_CMH5gfm6UsQP4Hnf2RNA</recordid><startdate>198902</startdate><enddate>198902</enddate><creator>Dexter, D. T.</creator><creator>Carter, C. J.</creator><creator>Wells, F. R.</creator><creator>Javoy‐Agid, F.</creator><creator>Agid, Y.</creator><creator>Lees, A.</creator><creator>Jenner, P.</creator><creator>Marsden, C. D.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>198902</creationdate><title>Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease</title><author>Dexter, D. T. ; Carter, C. J. ; Wells, F. R. ; Javoy‐Agid, F. ; Agid, Y. ; Lees, A. ; Jenner, P. ; Marsden, C. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4961-d053b83535666988cb20f953b7ce17c2fd49b549aa1a289cf02eeea3cf625b4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aged</topic><topic>Animals</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Female</topic><topic>Ferrous Compounds - pharmacology</topic><topic>Free Radicals</topic><topic>Humans</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - metabolism</topic><topic>man</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson's disease</topic><topic>Postmortem Changes</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Substantia nigra</topic><topic>Substantia Nigra - drug effects</topic><topic>Substantia Nigra - metabolism</topic><topic>Thiobarbiturates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dexter, D. T.</creatorcontrib><creatorcontrib>Carter, C. J.</creatorcontrib><creatorcontrib>Wells, F. R.</creatorcontrib><creatorcontrib>Javoy‐Agid, F.</creatorcontrib><creatorcontrib>Agid, Y.</creatorcontrib><creatorcontrib>Lees, A.</creatorcontrib><creatorcontrib>Jenner, P.</creatorcontrib><creatorcontrib>Marsden, C. D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dexter, D. T.</au><au>Carter, C. J.</au><au>Wells, F. R.</au><au>Javoy‐Agid, F.</au><au>Agid, Y.</au><au>Lees, A.</au><au>Jenner, P.</au><au>Marsden, C. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1989-02</date><risdate>1989</risdate><volume>52</volume><issue>2</issue><spage>381</spage><epage>389</epage><pages>381-389</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Polyunsaturated fatty acid (PUFA) levels (an index of the amount of substrate available for lipid peroxidation) were measured in several brain regions from patients who died with Parkinson's disease and age‐matched control human postmortem brains. PUFA levels were reduced in parkinsonian substantia nigra compared to other brain regions and to control tissue. However, basal malondialdehyde (MDA; an intermediate in the lipid peroxidation process) levels were increased in parkinsonian nigra compared with other parkinsonian brain regions and control tissue. Expressing basal MDA levels in terms of PUFA content, the difference between parkinsonian and control substantia nigra was even more pronounced. Stimulating MDA production by incubating tissue with FeSO4 plus ascorbic acid, FeSO4 plus H2O2, or air alone produced lower MDA levels in the parkinsonian substantia nigra, probably reflecting the lower PUFA content. These results may indicate that an increased level of lipid peroxidation continues to occur in the parkinsonian nigra up to the time of death, perhaps because of continued exposure to excess free radicals derived from some endogenous or exogenous neurotoxic species.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2911023</pmid><doi>10.1111/j.1471-4159.1989.tb09133.x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 1989-02, Vol.52 (2), p.381-389 |
| issn | 0022-3042 1471-4159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15186070 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Animals Ascorbic Acid - pharmacology Biological and medical sciences Brain - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fatty Acids, Unsaturated - metabolism Female Ferrous Compounds - pharmacology Free Radicals Humans Hydrogen Peroxide - pharmacology Lipid Peroxidation Male Malondialdehyde Malondialdehyde - metabolism man Medical sciences Neurology Parkinson Disease - metabolism Parkinson's disease Postmortem Changes Rats Rats, Inbred Strains Substantia nigra Substantia Nigra - drug effects Substantia Nigra - metabolism Thiobarbiturates |
| title | Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A41%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Basal%20Lipid%20Peroxidation%20in%20Substantia%20Nigra%20Is%20Increased%20in%20Parkinson's%20Disease&rft.jtitle=Journal%20of%20neurochemistry&rft.au=Dexter,%20D.%20T.&rft.date=1989-02&rft.volume=52&rft.issue=2&rft.spage=381&rft.epage=389&rft.pages=381-389&rft.issn=0022-3042&rft.eissn=1471-4159&rft.coden=JONRA9&rft_id=info:doi/10.1111/j.1471-4159.1989.tb09133.x&rft_dat=%3Cproquest_cross%3E15186070%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15186070&rft_id=info:pmid/2911023&rfr_iscdi=true |