T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8+CD28+ T cells but not in CD8+CD28− T cells

A key feature of the aged human immune system is the accumulation of highly differentiated CD8+CD28− T cells, a phenomenon that negatively influences immune function in the elderly. However, the mechanisms that regulate survival or death of CD8+CD28− T cells remain incompletely understood. Macroauto...

Ausführliche Beschreibung