The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle
Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates diverse cellular processes, such as development, reprogramming, differentiation, and proliferation. In regards to these processes, studies of Dot1/DOT1L-dependent H3K79 methylation have mainly focused on the transc...
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| Veröffentlicht in: | Cell cycle (Georgetown, Tex.) Tex.), 2014-03, Vol.13 (5), p.726-738 |
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| creator | Kim, Wootae Choi, Minji Kim, Ja-Eun |
| description | Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates diverse cellular processes, such as development, reprogramming, differentiation, and proliferation. In regards to these processes, studies of Dot1/DOT1L-dependent H3K79 methylation have mainly focused on the transcriptional regulation of specific genes. Although the gene transcription mediated by Dot1/DOT1L during the cell cycle is not fully understood, H3K79 methylation plays a critical role in the progression of G
1
phase, S phase, mitosis, and meiosis. This modification may contribute to the chromatin structure that controls gene expression, replication initiation, DNA damage response, microtubule reorganization, chromosome segregation, and heterochromatin formation. Overall, Dot1/DOT1L is required to maintain genomic and chromosomal stability. This review summarizes the several functions of Dot1/DOT1L and highlights its role in cell cycle regulation. |
| doi_str_mv | 10.4161/cc.28104 |
| format | Article |
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1
phase, S phase, mitosis, and meiosis. This modification may contribute to the chromatin structure that controls gene expression, replication initiation, DNA damage response, microtubule reorganization, chromosome segregation, and heterochromatin formation. Overall, Dot1/DOT1L is required to maintain genomic and chromosomal stability. This review summarizes the several functions of Dot1/DOT1L and highlights its role in cell cycle regulation.</description><identifier>ISSN: 1538-4101</identifier><identifier>EISSN: 1551-4005</identifier><identifier>DOI: 10.4161/cc.28104</identifier><identifier>PMID: 24526115</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; Cell Cycle ; Cellular Reprogramming ; Chromatin - genetics ; Chromatin - metabolism ; differentiation ; DNA Damage ; DOT1L ; H3K79 ; histone methyltransferase ; Histones - metabolism ; Humans ; Lysine - metabolism ; meiosis ; Methylation ; Methyltransferases - metabolism ; mitosis ; Neoplasms - metabolism ; Neoplasms - pathology ; proliferation ; replication ; Review ; senescence</subject><ispartof>Cell cycle (Georgetown, Tex.), 2014-03, Vol.13 (5), p.726-738</ispartof><rights>Copyright © 2014 Landes Bioscience 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-a91c87a3908e5568a03f4d56fe18a5483ad4a7ab305ee2a8181515a5ecb3033f3</citedby><cites>FETCH-LOGICAL-c482t-a91c87a3908e5568a03f4d56fe18a5483ad4a7ab305ee2a8181515a5ecb3033f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979909/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979909/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24526115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Wootae</creatorcontrib><creatorcontrib>Choi, Minji</creatorcontrib><creatorcontrib>Kim, Ja-Eun</creatorcontrib><title>The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle</title><title>Cell cycle (Georgetown, Tex.)</title><addtitle>Cell Cycle</addtitle><description>Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates diverse cellular processes, such as development, reprogramming, differentiation, and proliferation. In regards to these processes, studies of Dot1/DOT1L-dependent H3K79 methylation have mainly focused on the transcriptional regulation of specific genes. Although the gene transcription mediated by Dot1/DOT1L during the cell cycle is not fully understood, H3K79 methylation plays a critical role in the progression of G
1
phase, S phase, mitosis, and meiosis. This modification may contribute to the chromatin structure that controls gene expression, replication initiation, DNA damage response, microtubule reorganization, chromosome segregation, and heterochromatin formation. Overall, Dot1/DOT1L is required to maintain genomic and chromosomal stability. This review summarizes the several functions of Dot1/DOT1L and highlights its role in cell cycle regulation.</description><subject>Animals</subject><subject>Cell Cycle</subject><subject>Cellular Reprogramming</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>differentiation</subject><subject>DNA Damage</subject><subject>DOT1L</subject><subject>H3K79</subject><subject>histone methyltransferase</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Lysine - metabolism</subject><subject>meiosis</subject><subject>Methylation</subject><subject>Methyltransferases - metabolism</subject><subject>mitosis</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>proliferation</subject><subject>replication</subject><subject>Review</subject><subject>senescence</subject><issn>1538-4101</issn><issn>1551-4005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNplkVtLHDEUgENpqZcW-gskj30ZzZkkM5kXQbRaYUEo2-dwzJ64KZmJJtmW_fedVWstfcoh5-M7N8Y-gThW0MGJc8etAaHesH3QGholhH67i6VpFAjYYwel_BCiNf0A79leq3TbAeh99m25Jr4OpaaJ-Eh1vY0141Q8ZSzEL1KFk4ubJSw4Fo7c5VCDw8gz3W0i1pR58rzODkcxcrd1kT6wdx5joY_P7yH7fvllef61WdxcXZ-fLRqnTFsbHMCZHuUgDGndGRTSq5XuPIFBrYzElcIeb6XQRC0aMKBBoyY3f0np5SE7ffLeb25HWjma5s6jvc9hxLy1CYP9NzOFtb1LP60c-mEQwyz4_CzI6WFDpdoxlN0cOFHaFDvX640RQnR_UZdTKZn8SxkQdncC65x9PMGMHr1u6wX8s_MZkE9AmHzKI_5KOa5sxW1M2c-7d6FY-Z_2N1jBktk</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Kim, Wootae</creator><creator>Choi, Minji</creator><creator>Kim, Ja-Eun</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140301</creationdate><title>The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle</title><author>Kim, Wootae ; Choi, Minji ; Kim, Ja-Eun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-a91c87a3908e5568a03f4d56fe18a5483ad4a7ab305ee2a8181515a5ecb3033f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Cell Cycle</topic><topic>Cellular Reprogramming</topic><topic>Chromatin - genetics</topic><topic>Chromatin - metabolism</topic><topic>differentiation</topic><topic>DNA Damage</topic><topic>DOT1L</topic><topic>H3K79</topic><topic>histone methyltransferase</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Lysine - metabolism</topic><topic>meiosis</topic><topic>Methylation</topic><topic>Methyltransferases - metabolism</topic><topic>mitosis</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>proliferation</topic><topic>replication</topic><topic>Review</topic><topic>senescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Wootae</creatorcontrib><creatorcontrib>Choi, Minji</creatorcontrib><creatorcontrib>Kim, Ja-Eun</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell cycle (Georgetown, Tex.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Wootae</au><au>Choi, Minji</au><au>Kim, Ja-Eun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle</atitle><jtitle>Cell cycle (Georgetown, Tex.)</jtitle><addtitle>Cell Cycle</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>13</volume><issue>5</issue><spage>726</spage><epage>738</epage><pages>726-738</pages><issn>1538-4101</issn><eissn>1551-4005</eissn><abstract>Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates diverse cellular processes, such as development, reprogramming, differentiation, and proliferation. In regards to these processes, studies of Dot1/DOT1L-dependent H3K79 methylation have mainly focused on the transcriptional regulation of specific genes. Although the gene transcription mediated by Dot1/DOT1L during the cell cycle is not fully understood, H3K79 methylation plays a critical role in the progression of G
1
phase, S phase, mitosis, and meiosis. This modification may contribute to the chromatin structure that controls gene expression, replication initiation, DNA damage response, microtubule reorganization, chromosome segregation, and heterochromatin formation. Overall, Dot1/DOT1L is required to maintain genomic and chromosomal stability. This review summarizes the several functions of Dot1/DOT1L and highlights its role in cell cycle regulation.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>24526115</pmid><doi>10.4161/cc.28104</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cell Cycle Cellular Reprogramming Chromatin - genetics Chromatin - metabolism differentiation DNA Damage DOT1L H3K79 histone methyltransferase Histones - metabolism Humans Lysine - metabolism meiosis Methylation Methyltransferases - metabolism mitosis Neoplasms - metabolism Neoplasms - pathology proliferation replication Review senescence |
| title | The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle |
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