Impact of Hydrocortisone on Adult Height in Congenital Adrenal Hyperplasia—The Minnesota Cohort
Objective To estimate the impact of the average daily dose of hydrocortisone (HC) on the amount of growth attained in children with congenital adrenal hyperplasia (CAH). The effect of glucocorticoid therapy on adult height (AH) in children with CAH has yet to be elucidated. Study design Triple-logis...
Gespeichert in:
| Veröffentlicht in: | The Journal of pediatrics 2014-05, Vol.164 (5), p.1141-1146.e1 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1146.e1 |
|---|---|
| container_issue | 5 |
| container_start_page | 1141 |
| container_title | The Journal of pediatrics |
| container_volume | 164 |
| creator | Sarafoglou, Kyriakie, MD Addo, O. Yaw, PhD Turcotte, Lucie, MD Otten, Noelle, MD Wickremasinghe, Andrea, MD Pittock, Siobhan, MD Kyllo, Jennifer, MD Lteif, Aida N., MD Himes, John H., PhD Miller, Bradley S., MD, PhD |
| description | Objective To estimate the impact of the average daily dose of hydrocortisone (HC) on the amount of growth attained in children with congenital adrenal hyperplasia (CAH). The effect of glucocorticoid therapy on adult height (AH) in children with CAH has yet to be elucidated. Study design Triple-logistic models estimating components of growth and maturation were fitted to longitudinal records of 104 patients with classic CAH from 3 pediatric medical centers in Minnesota between 1955 and 2012. A total of 3664 clinical encounters were examined. Random-effects longitudinal models with time-related covariates were used to estimate the effect of HC therapy on linear growth. Results The predicted AH z -score (−0.7) was similar between the sexes and among CAH subtypes. The mean growth period HC dose was 18.9 ± 5.6 mg/m2 /day. In the final regression model, HC dose was negatively associated with predicted AH, with each mg/m2 /day increase in average growth period HC dose predicting a 0.37-cm decrease in AH ( P |
| doi_str_mv | 10.1016/j.jpeds.2014.01.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1517879611</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347614000171</els_id><sourcerecordid>1517879611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-80587eed9630ae46b88541be8c837e9f972284102e65e3f1c829b689c41a13da3</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhi1ERZfCEyChHLlkmYmdxDmAVK2ArdSqh5az5XUmXYesHewEaW88BE_Ik-CwhQMXpJHmMN8_o_l_xl4hrBGwetuv-5HauC4AxRowFT5hK4SmzivJ-VO2AiiKnIu6OmfPY-wBoBEAz9h5IcoKUIoV01eHUZsp8122PbbBGx8mG72jzLvssp2HKduSfdhPmXXZxrsHcnbSQxoFcqlvjyOFcdDR6p_ff9zvKbuxzlH0k074Pm17wc46PUR6-dgv2OePH-432_z69tPV5vI6NwLFlEsoZU3UNhUHTaLaSVkK3JE0ktfUdE1dFFIgFFSVxDs0smh2lWySWiNvNb9gb057x-C_zhQndbDR0DBoR36OCkusZd1UiAnlJ9QEH2OgTo3BHnQ4KgS1eKt69dtbtXirAFMtqtePB-bdgdq_mj9mJuDdCaD05jdLQUVjyRlqbSAzqdbb_xx4_4_eDNZZo4cvdKTY-zkky9MnKhYK1N0S75IuplABa-S_AGxroL8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1517879611</pqid></control><display><type>article</type><title>Impact of Hydrocortisone on Adult Height in Congenital Adrenal Hyperplasia—The Minnesota Cohort</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Sarafoglou, Kyriakie, MD ; Addo, O. Yaw, PhD ; Turcotte, Lucie, MD ; Otten, Noelle, MD ; Wickremasinghe, Andrea, MD ; Pittock, Siobhan, MD ; Kyllo, Jennifer, MD ; Lteif, Aida N., MD ; Himes, John H., PhD ; Miller, Bradley S., MD, PhD</creator><creatorcontrib>Sarafoglou, Kyriakie, MD ; Addo, O. Yaw, PhD ; Turcotte, Lucie, MD ; Otten, Noelle, MD ; Wickremasinghe, Andrea, MD ; Pittock, Siobhan, MD ; Kyllo, Jennifer, MD ; Lteif, Aida N., MD ; Himes, John H., PhD ; Miller, Bradley S., MD, PhD</creatorcontrib><description>Objective To estimate the impact of the average daily dose of hydrocortisone (HC) on the amount of growth attained in children with congenital adrenal hyperplasia (CAH). The effect of glucocorticoid therapy on adult height (AH) in children with CAH has yet to be elucidated. Study design Triple-logistic models estimating components of growth and maturation were fitted to longitudinal records of 104 patients with classic CAH from 3 pediatric medical centers in Minnesota between 1955 and 2012. A total of 3664 clinical encounters were examined. Random-effects longitudinal models with time-related covariates were used to estimate the effect of HC therapy on linear growth. Results The predicted AH z -score (−0.7) was similar between the sexes and among CAH subtypes. The mean growth period HC dose was 18.9 ± 5.6 mg/m2 /day. In the final regression model, HC dose was negatively associated with predicted AH, with each mg/m2 /day increase in average growth period HC dose predicting a 0.37-cm decrease in AH ( P < .004). Conclusion This study has quantified the fractional reduction in predicted final AH with an incremental increase in HC dose. These findings have important clinical implications in the decision making balance between HC replacement dose and adrenal androgen suppression in children with CAH.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2014.01.011</identifier><identifier>PMID: 24560184</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adrenal Hyperplasia, Congenital - drug therapy ; Adult ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Body Height - drug effects ; Child ; Child, Preschool ; Cohort Studies ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Hydrocortisone - pharmacology ; Hydrocortisone - therapeutic use ; Infant ; Linear Models ; Logistic Models ; Male ; Minnesota ; Pediatrics ; Treatment Outcome</subject><ispartof>The Journal of pediatrics, 2014-05, Vol.164 (5), p.1141-1146.e1</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-80587eed9630ae46b88541be8c837e9f972284102e65e3f1c829b689c41a13da3</citedby><cites>FETCH-LOGICAL-c414t-80587eed9630ae46b88541be8c837e9f972284102e65e3f1c829b689c41a13da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2014.01.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24560184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarafoglou, Kyriakie, MD</creatorcontrib><creatorcontrib>Addo, O. Yaw, PhD</creatorcontrib><creatorcontrib>Turcotte, Lucie, MD</creatorcontrib><creatorcontrib>Otten, Noelle, MD</creatorcontrib><creatorcontrib>Wickremasinghe, Andrea, MD</creatorcontrib><creatorcontrib>Pittock, Siobhan, MD</creatorcontrib><creatorcontrib>Kyllo, Jennifer, MD</creatorcontrib><creatorcontrib>Lteif, Aida N., MD</creatorcontrib><creatorcontrib>Himes, John H., PhD</creatorcontrib><creatorcontrib>Miller, Bradley S., MD, PhD</creatorcontrib><title>Impact of Hydrocortisone on Adult Height in Congenital Adrenal Hyperplasia—The Minnesota Cohort</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To estimate the impact of the average daily dose of hydrocortisone (HC) on the amount of growth attained in children with congenital adrenal hyperplasia (CAH). The effect of glucocorticoid therapy on adult height (AH) in children with CAH has yet to be elucidated. Study design Triple-logistic models estimating components of growth and maturation were fitted to longitudinal records of 104 patients with classic CAH from 3 pediatric medical centers in Minnesota between 1955 and 2012. A total of 3664 clinical encounters were examined. Random-effects longitudinal models with time-related covariates were used to estimate the effect of HC therapy on linear growth. Results The predicted AH z -score (−0.7) was similar between the sexes and among CAH subtypes. The mean growth period HC dose was 18.9 ± 5.6 mg/m2 /day. In the final regression model, HC dose was negatively associated with predicted AH, with each mg/m2 /day increase in average growth period HC dose predicting a 0.37-cm decrease in AH ( P < .004). Conclusion This study has quantified the fractional reduction in predicted final AH with an incremental increase in HC dose. These findings have important clinical implications in the decision making balance between HC replacement dose and adrenal androgen suppression in children with CAH.</description><subject>Adolescent</subject><subject>Adrenal Hyperplasia, Congenital - drug therapy</subject><subject>Adult</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Body Height - drug effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hydrocortisone - pharmacology</subject><subject>Hydrocortisone - therapeutic use</subject><subject>Infant</subject><subject>Linear Models</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Minnesota</subject><subject>Pediatrics</subject><subject>Treatment Outcome</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi1ERZfCEyChHLlkmYmdxDmAVK2ArdSqh5az5XUmXYesHewEaW88BE_Ik-CwhQMXpJHmMN8_o_l_xl4hrBGwetuv-5HauC4AxRowFT5hK4SmzivJ-VO2AiiKnIu6OmfPY-wBoBEAz9h5IcoKUIoV01eHUZsp8122PbbBGx8mG72jzLvssp2HKduSfdhPmXXZxrsHcnbSQxoFcqlvjyOFcdDR6p_ff9zvKbuxzlH0k074Pm17wc46PUR6-dgv2OePH-432_z69tPV5vI6NwLFlEsoZU3UNhUHTaLaSVkK3JE0ktfUdE1dFFIgFFSVxDs0smh2lWySWiNvNb9gb057x-C_zhQndbDR0DBoR36OCkusZd1UiAnlJ9QEH2OgTo3BHnQ4KgS1eKt69dtbtXirAFMtqtePB-bdgdq_mj9mJuDdCaD05jdLQUVjyRlqbSAzqdbb_xx4_4_eDNZZo4cvdKTY-zkky9MnKhYK1N0S75IuplABa-S_AGxroL8</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Sarafoglou, Kyriakie, MD</creator><creator>Addo, O. Yaw, PhD</creator><creator>Turcotte, Lucie, MD</creator><creator>Otten, Noelle, MD</creator><creator>Wickremasinghe, Andrea, MD</creator><creator>Pittock, Siobhan, MD</creator><creator>Kyllo, Jennifer, MD</creator><creator>Lteif, Aida N., MD</creator><creator>Himes, John H., PhD</creator><creator>Miller, Bradley S., MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Impact of Hydrocortisone on Adult Height in Congenital Adrenal Hyperplasia—The Minnesota Cohort</title><author>Sarafoglou, Kyriakie, MD ; Addo, O. Yaw, PhD ; Turcotte, Lucie, MD ; Otten, Noelle, MD ; Wickremasinghe, Andrea, MD ; Pittock, Siobhan, MD ; Kyllo, Jennifer, MD ; Lteif, Aida N., MD ; Himes, John H., PhD ; Miller, Bradley S., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-80587eed9630ae46b88541be8c837e9f972284102e65e3f1c829b689c41a13da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adrenal Hyperplasia, Congenital - drug therapy</topic><topic>Adult</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Body Height - drug effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hydrocortisone - pharmacology</topic><topic>Hydrocortisone - therapeutic use</topic><topic>Infant</topic><topic>Linear Models</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Minnesota</topic><topic>Pediatrics</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarafoglou, Kyriakie, MD</creatorcontrib><creatorcontrib>Addo, O. Yaw, PhD</creatorcontrib><creatorcontrib>Turcotte, Lucie, MD</creatorcontrib><creatorcontrib>Otten, Noelle, MD</creatorcontrib><creatorcontrib>Wickremasinghe, Andrea, MD</creatorcontrib><creatorcontrib>Pittock, Siobhan, MD</creatorcontrib><creatorcontrib>Kyllo, Jennifer, MD</creatorcontrib><creatorcontrib>Lteif, Aida N., MD</creatorcontrib><creatorcontrib>Himes, John H., PhD</creatorcontrib><creatorcontrib>Miller, Bradley S., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarafoglou, Kyriakie, MD</au><au>Addo, O. Yaw, PhD</au><au>Turcotte, Lucie, MD</au><au>Otten, Noelle, MD</au><au>Wickremasinghe, Andrea, MD</au><au>Pittock, Siobhan, MD</au><au>Kyllo, Jennifer, MD</au><au>Lteif, Aida N., MD</au><au>Himes, John H., PhD</au><au>Miller, Bradley S., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Hydrocortisone on Adult Height in Congenital Adrenal Hyperplasia—The Minnesota Cohort</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>164</volume><issue>5</issue><spage>1141</spage><epage>1146.e1</epage><pages>1141-1146.e1</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Objective To estimate the impact of the average daily dose of hydrocortisone (HC) on the amount of growth attained in children with congenital adrenal hyperplasia (CAH). The effect of glucocorticoid therapy on adult height (AH) in children with CAH has yet to be elucidated. Study design Triple-logistic models estimating components of growth and maturation were fitted to longitudinal records of 104 patients with classic CAH from 3 pediatric medical centers in Minnesota between 1955 and 2012. A total of 3664 clinical encounters were examined. Random-effects longitudinal models with time-related covariates were used to estimate the effect of HC therapy on linear growth. Results The predicted AH z -score (−0.7) was similar between the sexes and among CAH subtypes. The mean growth period HC dose was 18.9 ± 5.6 mg/m2 /day. In the final regression model, HC dose was negatively associated with predicted AH, with each mg/m2 /day increase in average growth period HC dose predicting a 0.37-cm decrease in AH ( P < .004). Conclusion This study has quantified the fractional reduction in predicted final AH with an incremental increase in HC dose. These findings have important clinical implications in the decision making balance between HC replacement dose and adrenal androgen suppression in children with CAH.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24560184</pmid><doi>10.1016/j.jpeds.2014.01.011</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 2014-05, Vol.164 (5), p.1141-1146.e1 |
| issn | 0022-3476 1097-6833 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1517879611 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adrenal Hyperplasia, Congenital - drug therapy Adult Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Body Height - drug effects Child Child, Preschool Cohort Studies Dose-Response Relationship, Drug Female Follow-Up Studies Humans Hydrocortisone - pharmacology Hydrocortisone - therapeutic use Infant Linear Models Logistic Models Male Minnesota Pediatrics Treatment Outcome |
| title | Impact of Hydrocortisone on Adult Height in Congenital Adrenal Hyperplasia—The Minnesota Cohort |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T08%3A25%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Hydrocortisone%20on%20Adult%20Height%20in%20Congenital%20Adrenal%20Hyperplasia%E2%80%94The%20Minnesota%20Cohort&rft.jtitle=The%20Journal%20of%20pediatrics&rft.au=Sarafoglou,%20Kyriakie,%20MD&rft.date=2014-05-01&rft.volume=164&rft.issue=5&rft.spage=1141&rft.epage=1146.e1&rft.pages=1141-1146.e1&rft.issn=0022-3476&rft.eissn=1097-6833&rft_id=info:doi/10.1016/j.jpeds.2014.01.011&rft_dat=%3Cproquest_cross%3E1517879611%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1517879611&rft_id=info:pmid/24560184&rft_els_id=S0022347614000171&rfr_iscdi=true |