A new device for the quantitative assessment of dopaminergic drug effects in unilateral MPTP-lesioned monkeys

Non-human primates exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) have been employed to study the clinical features of parkinsonism. Monkeys lesioned by unilateral intracarotid administration of MPTP display spontaneous and drug responsive turning behavior. However this seems to corr...

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Veröffentlicht in:	Neuroscience letters 1988-12, Vol.95 (1), p.257-261
Hauptverfasser:	Wolters, E.Ch, Kebabian, J.C., Guttman, M., Mak, E., Pate, B.D., Calne, D.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Assessment Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Disease Models, Animal Equipment Design Feeding Behavior - physiology Levodopa - therapeutic use Macaca fascicularis Male Medical sciences Movement - drug effects Movement time Neuropharmacology Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - drug therapy Parkinson Disease, Secondary - physiopathology Parkinson's disease Pharmacology. Drug treatments Pyridines - pharmacology Receptors, Dopamine - drug effects Receptors, Dopamine - physiology
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