A new device for the quantitative assessment of dopaminergic drug effects in unilateral MPTP-lesioned monkeys
Non-human primates exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) have been employed to study the clinical features of parkinsonism. Monkeys lesioned by unilateral intracarotid administration of MPTP display spontaneous and drug responsive turning behavior. However this seems to corr...
Gespeichert in:
| Veröffentlicht in: | Neuroscience letters 1988-12, Vol.95 (1), p.257-261 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 261 |
|---|---|
| container_issue | 1 |
| container_start_page | 257 |
| container_title | Neuroscience letters |
| container_volume | 95 |
| creator | Wolters, E.Ch Kebabian, J.C. Guttman, M. Mak, E. Pate, B.D. Calne, D.B. |
| description | Non-human primates exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) have been employed to study the clinical features of parkinsonism. Monkeys lesioned by unilateral intracarotid administration of MPTP display spontaneous and drug responsive turning behavior. However this seems to correlate poorly with their clinical deficits. We describe an objective measurement of arm movement velocity, applied in 4 cynomolgus monkeys before and after unilateral administration of MPTP. Reduced movement velocities correlated with clinical signs of unilateral flexed arm posture, rigidity, tremor and bradykinesia and could be reversed with
l-DOPA therapy. This measurement technique has advantages for the quantitative assessment of parkinsonian deficits and will permit the evaluation of dopaminergic therapy and transplantation in non-human primates. |
| doi_str_mv | 10.1016/0304-3940(88)90667-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15174336</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0304394088906672</els_id><sourcerecordid>15174336</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-c5ac638dd44da282cf815d8d7107e99e424fe17e2bdbf3beaf4eb3377b18a06b3</originalsourceid><addsrcrecordid>eNp9kDtvFDEUhS0ECkvgH4DkAiEoBvwa29NEiiJeUhApQm157OtgmLE3tmdR_j2z7GpLqluc7xxdfQi9pOQ9JVR-IJyIjg-CvNX63UCkVB17hDZUK9apQbHHaHNCnqJntf4ihPS0F2fojDPZK0U3aL7ECf5gD7voAIdccPsJ-H6xqcVmW9wBtrVCrTOkhnPAPm_tHBOUu-iwL8sdhhDAtYpjwkuKk21Q7IS_3dzedBPUmBN4POf0Gx7qc_Qk2KnCi-M9Rz8-fby9-tJdf__89eryunOCqta53jrJtfdCeMs0c0HT3muvKFEwDCCYCEAVsNGPgY9gg4CRc6VGqi2RIz9Hbw6725LvF6jNzLE6mCabIC_V0J4qwblcQXEAXcm1FghmW-Jsy4OhxOwtm71Cs1dotDb_LBu21l4d95dxBn8qHbWu-etjbquzUyg2uVhPmNSDJEKv2MUBg9XFLkIx1UVIDnwsq1Ljc_z_H38BC8eaig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15174336</pqid></control><display><type>article</type><title>A new device for the quantitative assessment of dopaminergic drug effects in unilateral MPTP-lesioned monkeys</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Wolters, E.Ch ; Kebabian, J.C. ; Guttman, M. ; Mak, E. ; Pate, B.D. ; Calne, D.B.</creator><creatorcontrib>Wolters, E.Ch ; Kebabian, J.C. ; Guttman, M. ; Mak, E. ; Pate, B.D. ; Calne, D.B.</creatorcontrib><description>Non-human primates exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) have been employed to study the clinical features of parkinsonism. Monkeys lesioned by unilateral intracarotid administration of MPTP display spontaneous and drug responsive turning behavior. However this seems to correlate poorly with their clinical deficits. We describe an objective measurement of arm movement velocity, applied in 4 cynomolgus monkeys before and after unilateral administration of MPTP. Reduced movement velocities correlated with clinical signs of unilateral flexed arm posture, rigidity, tremor and bradykinesia and could be reversed with
l-DOPA therapy. This measurement technique has advantages for the quantitative assessment of parkinsonian deficits and will permit the evaluation of dopaminergic therapy and transplantation in non-human primates.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(88)90667-2</identifier><identifier>PMID: 3265771</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Assessment ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Biological and medical sciences ; Disease Models, Animal ; Equipment Design ; Feeding Behavior - physiology ; Levodopa - therapeutic use ; Macaca fascicularis ; Male ; Medical sciences ; Movement - drug effects ; Movement time ; Neuropharmacology ; Parkinson Disease, Secondary - chemically induced ; Parkinson Disease, Secondary - drug therapy ; Parkinson Disease, Secondary - physiopathology ; Parkinson's disease ; Pharmacology. Drug treatments ; Pyridines - pharmacology ; Receptors, Dopamine - drug effects ; Receptors, Dopamine - physiology</subject><ispartof>Neuroscience letters, 1988-12, Vol.95 (1), p.257-261</ispartof><rights>1988</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c5ac638dd44da282cf815d8d7107e99e424fe17e2bdbf3beaf4eb3377b18a06b3</citedby><cites>FETCH-LOGICAL-c417t-c5ac638dd44da282cf815d8d7107e99e424fe17e2bdbf3beaf4eb3377b18a06b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(88)90667-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6896048$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3265771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolters, E.Ch</creatorcontrib><creatorcontrib>Kebabian, J.C.</creatorcontrib><creatorcontrib>Guttman, M.</creatorcontrib><creatorcontrib>Mak, E.</creatorcontrib><creatorcontrib>Pate, B.D.</creatorcontrib><creatorcontrib>Calne, D.B.</creatorcontrib><title>A new device for the quantitative assessment of dopaminergic drug effects in unilateral MPTP-lesioned monkeys</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Non-human primates exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) have been employed to study the clinical features of parkinsonism. Monkeys lesioned by unilateral intracarotid administration of MPTP display spontaneous and drug responsive turning behavior. However this seems to correlate poorly with their clinical deficits. We describe an objective measurement of arm movement velocity, applied in 4 cynomolgus monkeys before and after unilateral administration of MPTP. Reduced movement velocities correlated with clinical signs of unilateral flexed arm posture, rigidity, tremor and bradykinesia and could be reversed with
l-DOPA therapy. This measurement technique has advantages for the quantitative assessment of parkinsonian deficits and will permit the evaluation of dopaminergic therapy and transplantation in non-human primates.</description><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</subject><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Assessment</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Equipment Design</subject><subject>Feeding Behavior - physiology</subject><subject>Levodopa - therapeutic use</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Movement - drug effects</subject><subject>Movement time</subject><subject>Neuropharmacology</subject><subject>Parkinson Disease, Secondary - chemically induced</subject><subject>Parkinson Disease, Secondary - drug therapy</subject><subject>Parkinson Disease, Secondary - physiopathology</subject><subject>Parkinson's disease</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyridines - pharmacology</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Receptors, Dopamine - physiology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtvFDEUhS0ECkvgH4DkAiEoBvwa29NEiiJeUhApQm157OtgmLE3tmdR_j2z7GpLqluc7xxdfQi9pOQ9JVR-IJyIjg-CvNX63UCkVB17hDZUK9apQbHHaHNCnqJntf4ihPS0F2fojDPZK0U3aL7ECf5gD7voAIdccPsJ-H6xqcVmW9wBtrVCrTOkhnPAPm_tHBOUu-iwL8sdhhDAtYpjwkuKk21Q7IS_3dzedBPUmBN4POf0Gx7qc_Qk2KnCi-M9Rz8-fby9-tJdf__89eryunOCqta53jrJtfdCeMs0c0HT3muvKFEwDCCYCEAVsNGPgY9gg4CRc6VGqi2RIz9Hbw6725LvF6jNzLE6mCabIC_V0J4qwblcQXEAXcm1FghmW-Jsy4OhxOwtm71Cs1dotDb_LBu21l4d95dxBn8qHbWu-etjbquzUyg2uVhPmNSDJEKv2MUBg9XFLkIx1UVIDnwsq1Ljc_z_H38BC8eaig</recordid><startdate>19881219</startdate><enddate>19881219</enddate><creator>Wolters, E.Ch</creator><creator>Kebabian, J.C.</creator><creator>Guttman, M.</creator><creator>Mak, E.</creator><creator>Pate, B.D.</creator><creator>Calne, D.B.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19881219</creationdate><title>A new device for the quantitative assessment of dopaminergic drug effects in unilateral MPTP-lesioned monkeys</title><author>Wolters, E.Ch ; Kebabian, J.C. ; Guttman, M. ; Mak, E. ; Pate, B.D. ; Calne, D.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c5ac638dd44da282cf815d8d7107e99e424fe17e2bdbf3beaf4eb3377b18a06b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</topic><topic>Animals</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Assessment</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Equipment Design</topic><topic>Feeding Behavior - physiology</topic><topic>Levodopa - therapeutic use</topic><topic>Macaca fascicularis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Movement - drug effects</topic><topic>Movement time</topic><topic>Neuropharmacology</topic><topic>Parkinson Disease, Secondary - chemically induced</topic><topic>Parkinson Disease, Secondary - drug therapy</topic><topic>Parkinson Disease, Secondary - physiopathology</topic><topic>Parkinson's disease</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyridines - pharmacology</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Receptors, Dopamine - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolters, E.Ch</creatorcontrib><creatorcontrib>Kebabian, J.C.</creatorcontrib><creatorcontrib>Guttman, M.</creatorcontrib><creatorcontrib>Mak, E.</creatorcontrib><creatorcontrib>Pate, B.D.</creatorcontrib><creatorcontrib>Calne, D.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolters, E.Ch</au><au>Kebabian, J.C.</au><au>Guttman, M.</au><au>Mak, E.</au><au>Pate, B.D.</au><au>Calne, D.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new device for the quantitative assessment of dopaminergic drug effects in unilateral MPTP-lesioned monkeys</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1988-12-19</date><risdate>1988</risdate><volume>95</volume><issue>1</issue><spage>257</spage><epage>261</epage><pages>257-261</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Non-human primates exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) have been employed to study the clinical features of parkinsonism. Monkeys lesioned by unilateral intracarotid administration of MPTP display spontaneous and drug responsive turning behavior. However this seems to correlate poorly with their clinical deficits. We describe an objective measurement of arm movement velocity, applied in 4 cynomolgus monkeys before and after unilateral administration of MPTP. Reduced movement velocities correlated with clinical signs of unilateral flexed arm posture, rigidity, tremor and bradykinesia and could be reversed with
l-DOPA therapy. This measurement technique has advantages for the quantitative assessment of parkinsonian deficits and will permit the evaluation of dopaminergic therapy and transplantation in non-human primates.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3265771</pmid><doi>10.1016/0304-3940(88)90667-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1988-12, Vol.95 (1), p.257-261 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15174336 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Assessment Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Disease Models, Animal Equipment Design Feeding Behavior - physiology Levodopa - therapeutic use Macaca fascicularis Male Medical sciences Movement - drug effects Movement time Neuropharmacology Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - drug therapy Parkinson Disease, Secondary - physiopathology Parkinson's disease Pharmacology. Drug treatments Pyridines - pharmacology Receptors, Dopamine - drug effects Receptors, Dopamine - physiology |
| title | A new device for the quantitative assessment of dopaminergic drug effects in unilateral MPTP-lesioned monkeys |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T21%3A13%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20device%20for%20the%20quantitative%20assessment%20of%20dopaminergic%20drug%20effects%20in%20unilateral%20MPTP-lesioned%20monkeys&rft.jtitle=Neuroscience%20letters&rft.au=Wolters,%20E.Ch&rft.date=1988-12-19&rft.volume=95&rft.issue=1&rft.spage=257&rft.epage=261&rft.pages=257-261&rft.issn=0304-3940&rft.eissn=1872-7972&rft.coden=NELED5&rft_id=info:doi/10.1016/0304-3940(88)90667-2&rft_dat=%3Cproquest_cross%3E15174336%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15174336&rft_id=info:pmid/3265771&rft_els_id=0304394088906672&rfr_iscdi=true |