Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 225% of iron (III) in the substantia nigra of the parkinsonian patients compared to age matched co...
Gespeichert in:
| Veröffentlicht in: | Journal of Neural Transmission 1988-10, Vol.74 (3), p.199-205 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 205 |
|---|---|
| container_issue | 3 |
| container_start_page | 199 |
| container_title | Journal of Neural Transmission |
| container_volume | 74 |
| creator | SOFIC, E RIEDERER, P HEINSEN, H BEKCMANN, H REYNOLDS, G. P HEBENSTREIT, G YOUDIM, M. B. H |
| description | Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 225% of iron (III) in the substantia nigra of the parkinsonian patients compared to age matched controls. In the cortex (Brodmann area 21), hippocampus, putamen, and globus pallidus there was no significant difference in the levels of iron (III) and total iron. Thus the changes in total iron, iron (III) and the iron (II)/iron (III) ratio in the parkinsonian substantia nigra are likely to be involved in the pathophysiology and treatment of this disorder. |
| doi_str_mv | 10.1007/bf01244786 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15174311</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15174311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-69326879ede7d174e8d10e10ff811374b548e76aca655005ed08e33f2b7fe6803</originalsourceid><addsrcrecordid>eNo9kEFv1DAQhS0EKtuFC3ckHxCCSikza8f2HqFqaaRKXMo5miRjZEjsxfYe-PcE7dLTSPO-9x2eEG8QrhHAfho84E5r68wzsUGt2ga1Uc_FBhRAs2-NfikuS_kJAIjWXYgLtVuLqDeCujhmpsKTDDlF-aHruo-S4iRrqjSfnmOKlWOVIcpDKlUuKVdeZDkOpVKsgWQMPzLJ5OWB8q8QS4qBohwyhfhKvPA0F359vlvx_e728ea-efj2tbv5_NCMGl1tzF7tjLN7nthOaDW7CYERvHeIyuqh1Y6toZFM2wK0PIFjpfxusJ6NA7UV70_eQ06_j1xqv4Qy8jxT5HQsPbarVa2urbg6gWNOpWT2_SGHhfKfHqH_t2f_5e7_niv89mw9DgtPT-h5wDV_d86pjDT7THEM5QkzRinbovoLD3l7qw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15174311</pqid></control><display><type>article</type><title>Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>SOFIC, E ; RIEDERER, P ; HEINSEN, H ; BEKCMANN, H ; REYNOLDS, G. P ; HEBENSTREIT, G ; YOUDIM, M. B. H</creator><creatorcontrib>SOFIC, E ; RIEDERER, P ; HEINSEN, H ; BEKCMANN, H ; REYNOLDS, G. P ; HEBENSTREIT, G ; YOUDIM, M. B. H</creatorcontrib><description>Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 225% of iron (III) in the substantia nigra of the parkinsonian patients compared to age matched controls. In the cortex (Brodmann area 21), hippocampus, putamen, and globus pallidus there was no significant difference in the levels of iron (III) and total iron. Thus the changes in total iron, iron (III) and the iron (II)/iron (III) ratio in the parkinsonian substantia nigra are likely to be involved in the pathophysiology and treatment of this disorder.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/bf01244786</identifier><identifier>PMID: 3210014</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Ferric Compounds - metabolism ; Humans ; Iron - metabolism ; Male ; Medical sciences ; Neurology ; Parkinson Disease - metabolism ; Substantia Nigra - metabolism</subject><ispartof>Journal of Neural Transmission, 1988-10, Vol.74 (3), p.199-205</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-69326879ede7d174e8d10e10ff811374b548e76aca655005ed08e33f2b7fe6803</citedby><cites>FETCH-LOGICAL-c418t-69326879ede7d174e8d10e10ff811374b548e76aca655005ed08e33f2b7fe6803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6633751$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3210014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SOFIC, E</creatorcontrib><creatorcontrib>RIEDERER, P</creatorcontrib><creatorcontrib>HEINSEN, H</creatorcontrib><creatorcontrib>BEKCMANN, H</creatorcontrib><creatorcontrib>REYNOLDS, G. P</creatorcontrib><creatorcontrib>HEBENSTREIT, G</creatorcontrib><creatorcontrib>YOUDIM, M. B. H</creatorcontrib><title>Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm</addtitle><description>Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 225% of iron (III) in the substantia nigra of the parkinsonian patients compared to age matched controls. In the cortex (Brodmann area 21), hippocampus, putamen, and globus pallidus there was no significant difference in the levels of iron (III) and total iron. Thus the changes in total iron, iron (III) and the iron (II)/iron (III) ratio in the parkinsonian substantia nigra are likely to be involved in the pathophysiology and treatment of this disorder.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Ferric Compounds - metabolism</subject><subject>Humans</subject><subject>Iron - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Parkinson Disease - metabolism</subject><subject>Substantia Nigra - metabolism</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFv1DAQhS0EKtuFC3ckHxCCSikza8f2HqFqaaRKXMo5miRjZEjsxfYe-PcE7dLTSPO-9x2eEG8QrhHAfho84E5r68wzsUGt2ga1Uc_FBhRAs2-NfikuS_kJAIjWXYgLtVuLqDeCujhmpsKTDDlF-aHruo-S4iRrqjSfnmOKlWOVIcpDKlUuKVdeZDkOpVKsgWQMPzLJ5OWB8q8QS4qBohwyhfhKvPA0F359vlvx_e728ea-efj2tbv5_NCMGl1tzF7tjLN7nthOaDW7CYERvHeIyuqh1Y6toZFM2wK0PIFjpfxusJ6NA7UV70_eQ06_j1xqv4Qy8jxT5HQsPbarVa2urbg6gWNOpWT2_SGHhfKfHqH_t2f_5e7_niv89mw9DgtPT-h5wDV_d86pjDT7THEM5QkzRinbovoLD3l7qw</recordid><startdate>198810</startdate><enddate>198810</enddate><creator>SOFIC, E</creator><creator>RIEDERER, P</creator><creator>HEINSEN, H</creator><creator>BEKCMANN, H</creator><creator>REYNOLDS, G. P</creator><creator>HEBENSTREIT, G</creator><creator>YOUDIM, M. B. H</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>198810</creationdate><title>Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain</title><author>SOFIC, E ; RIEDERER, P ; HEINSEN, H ; BEKCMANN, H ; REYNOLDS, G. P ; HEBENSTREIT, G ; YOUDIM, M. B. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-69326879ede7d174e8d10e10ff811374b548e76aca655005ed08e33f2b7fe6803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Ferric Compounds - metabolism</topic><topic>Humans</topic><topic>Iron - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Parkinson Disease - metabolism</topic><topic>Substantia Nigra - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SOFIC, E</creatorcontrib><creatorcontrib>RIEDERER, P</creatorcontrib><creatorcontrib>HEINSEN, H</creatorcontrib><creatorcontrib>BEKCMANN, H</creatorcontrib><creatorcontrib>REYNOLDS, G. P</creatorcontrib><creatorcontrib>HEBENSTREIT, G</creatorcontrib><creatorcontrib>YOUDIM, M. B. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SOFIC, E</au><au>RIEDERER, P</au><au>HEINSEN, H</au><au>BEKCMANN, H</au><au>REYNOLDS, G. P</au><au>HEBENSTREIT, G</au><au>YOUDIM, M. B. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain</atitle><jtitle>Journal of Neural Transmission</jtitle><addtitle>J Neural Transm</addtitle><date>1988-10</date><risdate>1988</risdate><volume>74</volume><issue>3</issue><spage>199</spage><epage>205</epage><pages>199-205</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTMAH</coden><abstract>Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 225% of iron (III) in the substantia nigra of the parkinsonian patients compared to age matched controls. In the cortex (Brodmann area 21), hippocampus, putamen, and globus pallidus there was no significant difference in the levels of iron (III) and total iron. Thus the changes in total iron, iron (III) and the iron (II)/iron (III) ratio in the parkinsonian substantia nigra are likely to be involved in the pathophysiology and treatment of this disorder.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>3210014</pmid><doi>10.1007/bf01244786</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9564 |
| ispartof | Journal of Neural Transmission, 1988-10, Vol.74 (3), p.199-205 |
| issn | 0300-9564 1435-1463 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15174311 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Aged, 80 and over Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Ferric Compounds - metabolism Humans Iron - metabolism Male Medical sciences Neurology Parkinson Disease - metabolism Substantia Nigra - metabolism |
| title | Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T08%3A08%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20iron%20(III)%20and%20total%20iron%20content%20in%20post%20mortem%20substantia%20nigra%20of%20parkinsonian%20brain&rft.jtitle=Journal%20of%20Neural%20Transmission&rft.au=SOFIC,%20E&rft.date=1988-10&rft.volume=74&rft.issue=3&rft.spage=199&rft.epage=205&rft.pages=199-205&rft.issn=0300-9564&rft.eissn=1435-1463&rft.coden=JNTMAH&rft_id=info:doi/10.1007/bf01244786&rft_dat=%3Cproquest_cross%3E15174311%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15174311&rft_id=info:pmid/3210014&rfr_iscdi=true |