Deletion of Soluble Epoxide Hydrolase Attenuates Cardiac Hypertrophy via Down-Regulation of Cardiac Fibroblasts–Derived Fibroblast Growth Factor-2

OBJECTIVE:Inhibition of soluble epoxide hydrolase (Ephx2) has been shown to play a protective role in cardiac hypertrophy, but the mechanism is not fully understood. We tested the hypothesis that deletion of soluble epoxide hydrolase attenuates cardiac hypertrophy via down-regulation of cardiac fibr...

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Veröffentlicht in:	Critical care medicine 2014-05, Vol.42 (5), p.e345-e354
Hauptverfasser:	Zhang, Huanji, Wang, Tong, Zhang, Kun, Liu, Yu, Huang, Feifei, Zhu, Xinhong, Liu, Yang, Wang, Mong-Heng, Tang, Wanchun, Wang, Jingfeng, Huang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Cardiomegaly - chemically induced Cardiomegaly - genetics Cardiomegaly - metabolism Disease Models, Animal Down-Regulation Enzyme-Linked Immunosorbent Assay Epoxide Hydrolases - antagonists & inhibitors Epoxide Hydrolases - genetics Epoxide Hydrolases - metabolism Fibroblast Growth Factor 2 - blood Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism Fibroblasts - metabolism Gene Expression Regulation Male Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Confocal Myocardium - metabolism Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Prospective Studies Real-Time Polymerase Chain Reaction Vasoconstrictor Agents - pharmacology
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