N-Bromosuccinimide as an oxidant for the transition-metal-free synthesis of 2-aminobenzoxazoles from benzoxazoles and secondary amines
A facile and transition-metal-free method was developed through merging the ring opening of benzoxazoles with secondary amines and N-bromosuccinimide (NBS) mediated oxidative cyclization toward the synthesis of 2-aminobenzoxazoles. NBS was selected as a powerful oxidant in the oxidative cyclization...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2014-05, Vol.12 (19), p.3108-3113 |
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| container_end_page | 3113 |
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| container_issue | 19 |
| container_start_page | 3108 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 12 |
| creator | Wang, Xiaoe Xu, Daqian Miao, Chengxia Zhang, Qiaohong Sun, Wei |
| description | A facile and transition-metal-free method was developed through merging the ring opening of benzoxazoles with secondary amines and N-bromosuccinimide (NBS) mediated oxidative cyclization toward the synthesis of 2-aminobenzoxazoles. NBS was selected as a powerful oxidant in the oxidative cyclization of ring-opening amidines to provide the desirable 2-aminobenzoxazoles in excellent yields (up to 94%). |
| doi_str_mv | 10.1039/c4ob00386a |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2014-05, Vol.12 (19), p.3108-3113 |
| issn | 1477-0520 1477-0539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1517398009 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amination Amines - chemistry Benzoxazoles - chemical synthesis Benzoxazoles - chemistry Bromosuccinimide - chemistry Catalysis Cyclization Oxidants - chemistry Oxidation-Reduction Receptors, Somatostatin - antagonists & inhibitors Transition Elements - chemistry |
| title | N-Bromosuccinimide as an oxidant for the transition-metal-free synthesis of 2-aminobenzoxazoles from benzoxazoles and secondary amines |
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