Neural correlation of successful cognitive behaviour therapy for spider phobia: A magnetoencephalography study
Abstract Cognitive behavioural therapy (CBT) can be an effective treatment for spider phobia, but the underlying neural correlates of therapeutic change are yet to be specified. The present study used magnetoencephalography (MEG) to study responses within the first half second, to phobogenic stimuli...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2013-12, Vol.214 (3), p.444-451 |
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| creator | Wright, Barry Alderson-Day, Ben Prendergast, Garreth Kennedy, Juliette Bennett, Sophie Docherty, Mary Whitton, Clare Manea, Laura Gouws, Andre Tomlinson, Heather Green, Gary |
| description | Abstract Cognitive behavioural therapy (CBT) can be an effective treatment for spider phobia, but the underlying neural correlates of therapeutic change are yet to be specified. The present study used magnetoencephalography (MEG) to study responses within the first half second, to phobogenic stimuli in a group of individuals with spider phobia prior to treatment ( n =12) and then in nine of them following successful CBT (where they could touch and manage live large common house spiders) at least 9 months later. We also compared responses to a group of age-matched healthy control participants ( n =11). Participants viewed static photographs of real spiders, other fear-inducing images (e.g. snakes, sharks) and neutral stimuli (e.g. kittens). Beamforming methods were used to localise sources of significant power changes in response to stimuli. Prior to treatment, participants with spider phobia showed a significant maximum response in the right frontal pole when viewing images of real spiders specifically. No significant frontal response was observed for either control participants or participants with spider phobia post-treatment. In addition, participants' subjective ratings of spider stimuli significantly predicted peak responses in right frontal regions. The implications for understanding brain-based effects of cognitive therapies are discussed. |
| doi_str_mv | 10.1016/j.pscychresns.2013.09.011 |
| format | Article |
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The present study used magnetoencephalography (MEG) to study responses within the first half second, to phobogenic stimuli in a group of individuals with spider phobia prior to treatment ( n =12) and then in nine of them following successful CBT (where they could touch and manage live large common house spiders) at least 9 months later. We also compared responses to a group of age-matched healthy control participants ( n =11). Participants viewed static photographs of real spiders, other fear-inducing images (e.g. snakes, sharks) and neutral stimuli (e.g. kittens). Beamforming methods were used to localise sources of significant power changes in response to stimuli. Prior to treatment, participants with spider phobia showed a significant maximum response in the right frontal pole when viewing images of real spiders specifically. No significant frontal response was observed for either control participants or participants with spider phobia post-treatment. In addition, participants' subjective ratings of spider stimuli significantly predicted peak responses in right frontal regions. The implications for understanding brain-based effects of cognitive therapies are discussed.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2013.09.011</identifier><identifier>PMID: 24139305</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Animals ; Anxiety disorders. Neuroses ; Araneae ; Behavior therapy. Cognitive therapy ; Biological and medical sciences ; Brain activation ; Brain Mapping ; Case-Control Studies ; Cognitive Therapy ; Fear ; Fear - physiology ; Fear - psychology ; Female ; Frontal Lobe - cytology ; Frontal Lobe - pathology ; Frontal Lobe - physiopathology ; Humans ; Magnetoencephalography ; Male ; Medical sciences ; Neuroimaging ; Neurons - physiology ; Phobia ; Phobic Disorders - pathology ; Phobic Disorders - physiopathology ; Phobic Disorders - psychology ; Phobic Disorders - therapy ; Psychiatry ; Psychological therapy ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiology ; Simple phobia ; Spiders ; Treatments ; Young Adult</subject><ispartof>Psychiatry research. 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Neuroimaging</title><addtitle>Psychiatry Res</addtitle><description>Abstract Cognitive behavioural therapy (CBT) can be an effective treatment for spider phobia, but the underlying neural correlates of therapeutic change are yet to be specified. The present study used magnetoencephalography (MEG) to study responses within the first half second, to phobogenic stimuli in a group of individuals with spider phobia prior to treatment ( n =12) and then in nine of them following successful CBT (where they could touch and manage live large common house spiders) at least 9 months later. We also compared responses to a group of age-matched healthy control participants ( n =11). Participants viewed static photographs of real spiders, other fear-inducing images (e.g. snakes, sharks) and neutral stimuli (e.g. kittens). Beamforming methods were used to localise sources of significant power changes in response to stimuli. Prior to treatment, participants with spider phobia showed a significant maximum response in the right frontal pole when viewing images of real spiders specifically. No significant frontal response was observed for either control participants or participants with spider phobia post-treatment. In addition, participants' subjective ratings of spider stimuli significantly predicted peak responses in right frontal regions. The implications for understanding brain-based effects of cognitive therapies are discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Animals</subject><subject>Anxiety disorders. Neuroses</subject><subject>Araneae</subject><subject>Behavior therapy. Cognitive therapy</subject><subject>Biological and medical sciences</subject><subject>Brain activation</subject><subject>Brain Mapping</subject><subject>Case-Control Studies</subject><subject>Cognitive Therapy</subject><subject>Fear</subject><subject>Fear - physiology</subject><subject>Fear - psychology</subject><subject>Female</subject><subject>Frontal Lobe - cytology</subject><subject>Frontal Lobe - pathology</subject><subject>Frontal Lobe - physiopathology</subject><subject>Humans</subject><subject>Magnetoencephalography</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuroimaging</subject><subject>Neurons - physiology</subject><subject>Phobia</subject><subject>Phobic Disorders - pathology</subject><subject>Phobic Disorders - physiopathology</subject><subject>Phobic Disorders - psychology</subject><subject>Phobic Disorders - therapy</subject><subject>Psychiatry</subject><subject>Psychological therapy</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiology</subject><subject>Simple phobia</subject><subject>Spiders</subject><subject>Treatments</subject><subject>Young Adult</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2P0zAQhiMEYsvCX0DmgMQlxV-xHQ5IqwoWpBUcgLPlOOPGJY2DnVTKv8dRy4K4gHzwwc_MWPO8RfGC4C3BRLw-bMdkF9tFSEPaUkzYFtdbTMiDYkOUpKWssHhYbHBNq5LXVF4VT1I6YEyZEuxxcUU5YTXD1aYYPsEcTY9siBF6M_kwoOBQmq2FlNy8vuwHP_kToAY6c_JhjmjqIJpxQS5ElEbfQkRjFxpv3qAbdDT7AaYAg4WxM33YZ7RbUJrmdnlaPHKmT_Dscl8X396_-7r7UN59vv24u7krLa-rqawaYl3LObOqIdRhUA3IxsnKOEu4kZBPrYQV3LbOUCIxbpmrucCNoJI6dl28OvcdY_gxQ5r00ScLfW8GCHPSpCJCVpVi6t8oF1wpoSTLaH1GbQwpRXB6jP5o4qIJ1qsZfdB_mNGrGY1rnc3k2ueXMXNzhPa-8peKDLy8ACZZ07toBuvTb05hLDFfud2Zg7y_k4eok_XrslsfwU66Df6_vvP2ry6294PPg7_DAumQLQ9ZkCY6UY31lzVKa5IIyykSsmY_AXsJyhI</recordid><startdate>20131230</startdate><enddate>20131230</enddate><creator>Wright, Barry</creator><creator>Alderson-Day, Ben</creator><creator>Prendergast, Garreth</creator><creator>Kennedy, Juliette</creator><creator>Bennett, Sophie</creator><creator>Docherty, Mary</creator><creator>Whitton, Clare</creator><creator>Manea, Laura</creator><creator>Gouws, Andre</creator><creator>Tomlinson, Heather</creator><creator>Green, Gary</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20131230</creationdate><title>Neural correlation of successful cognitive behaviour therapy for spider phobia: A magnetoencephalography study</title><author>Wright, Barry ; Alderson-Day, Ben ; Prendergast, Garreth ; Kennedy, Juliette ; Bennett, Sophie ; Docherty, Mary ; Whitton, Clare ; Manea, Laura ; Gouws, Andre ; Tomlinson, Heather ; Green, Gary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-5b1cfd443c8b12f0e8be7bf75afc14a7e7e7986c64cdfa21700d3f9460b6272f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Animals</topic><topic>Anxiety disorders. 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| subjects | Adolescent Adult Adult and adolescent clinical studies Animals Anxiety disorders. Neuroses Araneae Behavior therapy. Cognitive therapy Biological and medical sciences Brain activation Brain Mapping Case-Control Studies Cognitive Therapy Fear Fear - physiology Fear - psychology Female Frontal Lobe - cytology Frontal Lobe - pathology Frontal Lobe - physiopathology Humans Magnetoencephalography Male Medical sciences Neuroimaging Neurons - physiology Phobia Phobic Disorders - pathology Phobic Disorders - physiopathology Phobic Disorders - psychology Phobic Disorders - therapy Psychiatry Psychological therapy Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiology Simple phobia Spiders Treatments Young Adult |
| title | Neural correlation of successful cognitive behaviour therapy for spider phobia: A magnetoencephalography study |
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