Simultaneous activation of mitophagy and autophagy by staurosporine protects against dopaminergic neuronal cell death

Abnormal autophagy is frequently observed during dopaminergic neurodegeneration in Parkinson's disease (PD). However, it is not yet firmly established whether active autophagy is beneficial or pathogenic with respect to dopaminergic cell loss. Staurosporine, a common inducer of apoptosis, is of...

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Veröffentlicht in:	Neuroscience letters 2014-02, Vol.561, p.101-106
Hauptverfasser:	Ha, Ji-Young, Kim, Ji-Soo, Kim, Seo-Eun, Son, Jin H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Autophagy - drug effects Cell Line Dopaminergic Neurons - cytology Dopaminergic Neurons - drug effects Mice Mitochondrial Degradation - drug effects Protein Kinases - genetics Staurosporine - pharmacology
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