Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model

Cartilage degradation is the most predominant pathological change during osteoarthritis (OA). Furthermore, accumulating evidence suggests that an excess of matrix metalloproteinase-13 (MMP-13) plays a critical role in the breakdown of cartilage. Here, the effects of Icariin on the expression of MMP-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunopharmacology 2014-01, Vol.18 (1), p.175-181
Hauptverfasser:	Zeng, Li, Wang, Wei, Rong, Xiao-Feng, Zhong, Yu, Jia, Ping, Zhou, Guo-Qing, Li, Rong-Heng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anterior Cruciate Ligament - surgery beta Catenin - metabolism Cartilage - drug effects Cartilage - pathology Cell Line, Tumor Chondrosarcoma - drug therapy Chondrosarcoma - immunology Disease Models, Animal Flavonoids - administration & dosage Flavonoids - adverse effects Gene Expression Regulation - drug effects Humans Icariin Interleukin-1 - immunology JNK MAP Kinase Signaling System - drug effects Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - metabolism Matrix metalloproteinase-13 Osteoarthritis Osteoarthritis - drug therapy p38 Rats Rats, Sprague-Dawley Wnt Proteins - metabolism β-catenin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!