Equivalent cross-relaxation rate imaging positively correlates with pathological grade and cell density of adipocytic tumors
Abstract Objective Equivalent cross-relaxation rate imaging (ECRI) is an MRI technique used to evaluate qualitative changes in protein-water interactions. We aimed to prospectively evaluate the utility of ECRI for classification of adipocytic tumors. Materials and Methods Institutional Review Board...
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| Veröffentlicht in: | Magnetic resonance imaging 2014-04, Vol.32 (3), p.206-210 |
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| creator | Okuda, Hirofumi Matsushima, Shigeru Sugiura, Hideshi Yamada, Kenji Hamada, Shunsuke Nishida, Yoshihiro Ishiguro, Naoki |
| description | Abstract Objective Equivalent cross-relaxation rate imaging (ECRI) is an MRI technique used to evaluate qualitative changes in protein-water interactions. We aimed to prospectively evaluate the utility of ECRI for classification of adipocytic tumors. Materials and Methods Institutional Review Board approval was obtained and all patients provided informed consent. Study participants included 40 patients with adipocytic tumors who were diagnosed with lipomas (n = 22), atypical lipomatous tissue/well-differentiated liposarcoma (ALT/WDL; n = 9), myxoid/round cell liposarcoma (MyL; n = 6), and dedifferentiated liposarcoma (DDL; n = 3), and 20 control patients for whom subcutaneous fat in the buttock or thigh was analyzed. Results Mean ECR values of lipomas, ALT/WDL, and subcutaneous fat were low, and those of MyL and DDL were high. Mean ECR values of MyL and DDL were significantly higher than those of ALT/WDL. The cut-off value was 5.1%. There was a positive correlation between ECR value, pathological grade, and cell density in adipocytic tumors. Conclusion The ECR value positively correlates with pathological grade and cell density of adipocytic tumors. Our findings suggest that ECRI is a useful method for preoperative evaluation of adipocytic tumors. |
| doi_str_mv | 10.1016/j.mri.2013.12.004 |
| format | Article |
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We aimed to prospectively evaluate the utility of ECRI for classification of adipocytic tumors. Materials and Methods Institutional Review Board approval was obtained and all patients provided informed consent. Study participants included 40 patients with adipocytic tumors who were diagnosed with lipomas (n = 22), atypical lipomatous tissue/well-differentiated liposarcoma (ALT/WDL; n = 9), myxoid/round cell liposarcoma (MyL; n = 6), and dedifferentiated liposarcoma (DDL; n = 3), and 20 control patients for whom subcutaneous fat in the buttock or thigh was analyzed. Results Mean ECR values of lipomas, ALT/WDL, and subcutaneous fat were low, and those of MyL and DDL were high. Mean ECR values of MyL and DDL were significantly higher than those of ALT/WDL. The cut-off value was 5.1%. There was a positive correlation between ECR value, pathological grade, and cell density in adipocytic tumors. Conclusion The ECR value positively correlates with pathological grade and cell density of adipocytic tumors. Our findings suggest that ECRI is a useful method for preoperative evaluation of adipocytic tumors.</description><identifier>ISSN: 0730-725X</identifier><identifier>EISSN: 1873-5894</identifier><identifier>DOI: 10.1016/j.mri.2013.12.004</identifier><identifier>PMID: 24439360</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adipocytes - pathology ; Adipocytic tumors ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Algorithms ; Cell Count ; Equivalent cross-relaxation rate imaging ; Female ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Lipoma ; Lipoma - pathology ; Liposarcoma ; Liposarcoma - pathology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Neoplasm Grading ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Soft Tissue Neoplasms - pathology ; Young Adult</subject><ispartof>Magnetic resonance imaging, 2014-04, Vol.32 (3), p.206-210</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-71ffcb1286d45dc916efb6b39d231899933d51f2871fe3e9fb2b6a0dbfe20e43</citedby><cites>FETCH-LOGICAL-c441t-71ffcb1286d45dc916efb6b39d231899933d51f2871fe3e9fb2b6a0dbfe20e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0730725X13003883$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24439360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okuda, Hirofumi</creatorcontrib><creatorcontrib>Matsushima, Shigeru</creatorcontrib><creatorcontrib>Sugiura, Hideshi</creatorcontrib><creatorcontrib>Yamada, Kenji</creatorcontrib><creatorcontrib>Hamada, Shunsuke</creatorcontrib><creatorcontrib>Nishida, Yoshihiro</creatorcontrib><creatorcontrib>Ishiguro, Naoki</creatorcontrib><title>Equivalent cross-relaxation rate imaging positively correlates with pathological grade and cell density of adipocytic tumors</title><title>Magnetic resonance imaging</title><addtitle>Magn Reson Imaging</addtitle><description>Abstract Objective Equivalent cross-relaxation rate imaging (ECRI) is an MRI technique used to evaluate qualitative changes in protein-water interactions. We aimed to prospectively evaluate the utility of ECRI for classification of adipocytic tumors. Materials and Methods Institutional Review Board approval was obtained and all patients provided informed consent. Study participants included 40 patients with adipocytic tumors who were diagnosed with lipomas (n = 22), atypical lipomatous tissue/well-differentiated liposarcoma (ALT/WDL; n = 9), myxoid/round cell liposarcoma (MyL; n = 6), and dedifferentiated liposarcoma (DDL; n = 3), and 20 control patients for whom subcutaneous fat in the buttock or thigh was analyzed. Results Mean ECR values of lipomas, ALT/WDL, and subcutaneous fat were low, and those of MyL and DDL were high. Mean ECR values of MyL and DDL were significantly higher than those of ALT/WDL. The cut-off value was 5.1%. There was a positive correlation between ECR value, pathological grade, and cell density in adipocytic tumors. Conclusion The ECR value positively correlates with pathological grade and cell density of adipocytic tumors. Our findings suggest that ECRI is a useful method for preoperative evaluation of adipocytic tumors.</description><subject>Adipocytes - pathology</subject><subject>Adipocytic tumors</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Algorithms</subject><subject>Cell Count</subject><subject>Equivalent cross-relaxation rate imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Lipoma</subject><subject>Lipoma - pathology</subject><subject>Liposarcoma</subject><subject>Liposarcoma - pathology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Young Adult</subject><issn>0730-725X</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAURS0EotPCD2CDvGST4GfnU0hIqCoFqRILumBnOfbL1EMSp7YzEIkfj8MUFiwQK2_OvbLueYS8AJYDg-r1IR-9zTkDkQPPGSsekR00tcjKpi0ekx2rBctqXn45I-chHBhjJRflU3LGi0K0omI78uPqfrFHNeAUqfYuhMzjoL6raN1EvYpI7aj2dtrT2QUb7RGHlWrnNypioN9svKOzinducHur1UD3XhmkajJU4zBQg1PKrdT1VBk7O71Gq2lcRufDM_KkV0PA5w_vBbl9f3V7-SG7-XT98fLdTaaLAmJWQ9_rDnhTmaI0uoUK-67qRGu4gKZtWyFMCT1vEogC277jXaWY6XrkDAtxQV6damfv7hcMUY42bJ9TE7olSCihqktgAv4DZdCIqipZQuGE_prNYy9nn7byqwQmNz3yIJMeuemRwGXSkzIvH-qXbkTzJ_HbRwLenABMcxwtehm0xUmjsR51lMbZf9a__SutBzttVr7iiuHgFj-lnSXIkALy83Yf23mAYEw0jRA_AbEVuCU</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Okuda, Hirofumi</creator><creator>Matsushima, Shigeru</creator><creator>Sugiura, Hideshi</creator><creator>Yamada, Kenji</creator><creator>Hamada, Shunsuke</creator><creator>Nishida, Yoshihiro</creator><creator>Ishiguro, Naoki</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20140401</creationdate><title>Equivalent cross-relaxation rate imaging positively correlates with pathological grade and cell density of adipocytic tumors</title><author>Okuda, Hirofumi ; Matsushima, Shigeru ; Sugiura, Hideshi ; Yamada, Kenji ; Hamada, Shunsuke ; Nishida, Yoshihiro ; Ishiguro, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-71ffcb1286d45dc916efb6b39d231899933d51f2871fe3e9fb2b6a0dbfe20e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adipocytes - pathology</topic><topic>Adipocytic tumors</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Algorithms</topic><topic>Cell Count</topic><topic>Equivalent cross-relaxation rate imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Lipoma</topic><topic>Lipoma - pathology</topic><topic>Liposarcoma</topic><topic>Liposarcoma - pathology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Soft Tissue Neoplasms - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okuda, Hirofumi</creatorcontrib><creatorcontrib>Matsushima, Shigeru</creatorcontrib><creatorcontrib>Sugiura, Hideshi</creatorcontrib><creatorcontrib>Yamada, Kenji</creatorcontrib><creatorcontrib>Hamada, Shunsuke</creatorcontrib><creatorcontrib>Nishida, Yoshihiro</creatorcontrib><creatorcontrib>Ishiguro, Naoki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okuda, Hirofumi</au><au>Matsushima, Shigeru</au><au>Sugiura, Hideshi</au><au>Yamada, Kenji</au><au>Hamada, Shunsuke</au><au>Nishida, Yoshihiro</au><au>Ishiguro, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Equivalent cross-relaxation rate imaging positively correlates with pathological grade and cell density of adipocytic tumors</atitle><jtitle>Magnetic resonance imaging</jtitle><addtitle>Magn Reson Imaging</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>32</volume><issue>3</issue><spage>206</spage><epage>210</epage><pages>206-210</pages><issn>0730-725X</issn><eissn>1873-5894</eissn><abstract>Abstract Objective Equivalent cross-relaxation rate imaging (ECRI) is an MRI technique used to evaluate qualitative changes in protein-water interactions. We aimed to prospectively evaluate the utility of ECRI for classification of adipocytic tumors. Materials and Methods Institutional Review Board approval was obtained and all patients provided informed consent. Study participants included 40 patients with adipocytic tumors who were diagnosed with lipomas (n = 22), atypical lipomatous tissue/well-differentiated liposarcoma (ALT/WDL; n = 9), myxoid/round cell liposarcoma (MyL; n = 6), and dedifferentiated liposarcoma (DDL; n = 3), and 20 control patients for whom subcutaneous fat in the buttock or thigh was analyzed. Results Mean ECR values of lipomas, ALT/WDL, and subcutaneous fat were low, and those of MyL and DDL were high. Mean ECR values of MyL and DDL were significantly higher than those of ALT/WDL. The cut-off value was 5.1%. There was a positive correlation between ECR value, pathological grade, and cell density in adipocytic tumors. Conclusion The ECR value positively correlates with pathological grade and cell density of adipocytic tumors. Our findings suggest that ECRI is a useful method for preoperative evaluation of adipocytic tumors.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>24439360</pmid><doi>10.1016/j.mri.2013.12.004</doi><tpages>5</tpages></addata></record> |
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| subjects | Adipocytes - pathology Adipocytic tumors Adolescent Adult Aged Aged, 80 and over Algorithms Cell Count Equivalent cross-relaxation rate imaging Female Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Lipoma Lipoma - pathology Liposarcoma Liposarcoma - pathology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Neoplasm Grading Radiology Reproducibility of Results Sensitivity and Specificity Soft Tissue Neoplasms - pathology Young Adult |
| title | Equivalent cross-relaxation rate imaging positively correlates with pathological grade and cell density of adipocytic tumors |
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