Neonatal colonization of germ-free mice with Bifidobacterium longum prevents allergic sensitization to major birch pollen allergen Bet v 1

Highlights • B. longum was tested for perinatal intervention against the allergic sensitization. • Neonatal mother-to-offspring mono-colonization model was used. • B. longum suppressed Bet v 1-specific immune responses on humoral and cellular level. • B. longum induced increased levels of regulatory...

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Veröffentlicht in:	Vaccine 2013-11, Vol.31 (46), p.5405-5412
Hauptverfasser:	Schwarzer, Martin, Srutkova, Dagmar, Schabussova, Irma, Hudcovic, Tomas, Akgün, Johnnie, Wiedermann, Ursula, Kozakova, Hana
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Allergens Allergies Allergy Allergy and Immunology Animals Antigens, Plant - immunology Applied microbiology Bacteriology Betula Bifidobacterium Bifidobacterium - growth & development Bifidobacterium longum Bifidobacterium longum subsp. longum Biological and medical sciences blood serum Bone marrow cell culture Colonization Cytokines - secretion dendritic cells Disease Models, Animal Disease prevention Feces Female Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - microbiology germ-free animals Germ-Free Life Germ-free mice Hexosaminidases - metabolism humans hypersensitivity Hypersensitivity - prevention & control immune response Immune system Immune Tolerance Immunization immunoglobulin E Immunoglobulin E - blood immunoglobulin G interleukin-10 Ligands Male Mice Mice, Inbred BALB C Microbiology Miscellaneous mitogen-activated protein kinase Offspring Pollen Probiotics progeny protective effect signal transduction spleen Studies TLR2 transforming growth factor beta vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Yogurt
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Beschreibung
Zusammenfassung:	Highlights • B. longum was tested for perinatal intervention against the allergic sensitization. • Neonatal mother-to-offspring mono-colonization model was used. • B. longum suppressed Bet v 1-specific immune responses on humoral and cellular level. • B. longum induced increased levels of regulatory cytokines IL-10 and TGF-β. • B. longum induced production of IL-10 in TLR2-, MyD88-, and MAPK-dependent manner.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.09.014