Controlled release of 5-fluorouracil from microporous zeolites
Abstract Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release st...
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| Veröffentlicht in: | Nanomedicine 2014, Vol.10 (1), p.197-205 |
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| creator | Spanakis, Marios, PhD Bouropoulos, Nikolaos, PhD Theodoropoulos, Dimitrios, MSc Sygellou, Lamprini, PhD Ewart, Sinead, MSc Moschovi, Anastasia Maria, PhD Siokou, Angeliki, PhD Niopas, Ioannis, PhD Kachrimanis, Kyriakos, PhD Nikolakis, Vladimiros, PhD Cox, Paul A., PhD Vizirianakis, Ioannis S., PhD Fatouros, Dimitrios G., PhD |
| description | Abstract Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles. From the Clinical Editor This article describes zeolite-based nanoparticles in generating time-controlled release of 5-FU from zeolite preparations for anti-cancer therapy. |
| doi_str_mv | 10.1016/j.nano.2013.06.016 |
| format | Article |
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The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles. From the Clinical Editor This article describes zeolite-based nanoparticles in generating time-controlled release of 5-FU from zeolite preparations for anti-cancer therapy.</description><identifier>ISSN: 1549-9634</identifier><identifier>EISSN: 1549-9642</identifier><identifier>DOI: 10.1016/j.nano.2013.06.016</identifier><identifier>PMID: 23916887</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Caco-2 Cells ; Cell Survival - drug effects ; Controlled release ; Cytocompatibility ; Diffusion ; Drug Carriers - administration & dosage ; Drug Carriers - chemistry ; Fluorouracil - administration & dosage ; Fluorouracil - chemistry ; Humans ; Internal Medicine ; Kinetics ; Molecular Dynamics Simulation ; Molecular modeling ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Neoplasms - drug therapy ; Spectroscopy, Fourier Transform Infrared ; Zeolites ; Zeolites - administration & dosage ; Zeolites - chemistry</subject><ispartof>Nanomedicine, 2014, Vol.10 (1), p.197-205</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>2013.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-63839d56422e8f74401542de5123702380bb5128b57273347f00a72e63a634b23</citedby><cites>FETCH-LOGICAL-c488t-63839d56422e8f74401542de5123702380bb5128b57273347f00a72e63a634b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1549963413003523$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23916887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spanakis, Marios, PhD</creatorcontrib><creatorcontrib>Bouropoulos, Nikolaos, PhD</creatorcontrib><creatorcontrib>Theodoropoulos, Dimitrios, MSc</creatorcontrib><creatorcontrib>Sygellou, Lamprini, PhD</creatorcontrib><creatorcontrib>Ewart, Sinead, MSc</creatorcontrib><creatorcontrib>Moschovi, Anastasia Maria, PhD</creatorcontrib><creatorcontrib>Siokou, Angeliki, PhD</creatorcontrib><creatorcontrib>Niopas, Ioannis, PhD</creatorcontrib><creatorcontrib>Kachrimanis, Kyriakos, PhD</creatorcontrib><creatorcontrib>Nikolakis, Vladimiros, PhD</creatorcontrib><creatorcontrib>Cox, Paul A., PhD</creatorcontrib><creatorcontrib>Vizirianakis, Ioannis S., PhD</creatorcontrib><creatorcontrib>Fatouros, Dimitrios G., PhD</creatorcontrib><title>Controlled release of 5-fluorouracil from microporous zeolites</title><title>Nanomedicine</title><addtitle>Nanomedicine</addtitle><description>Abstract Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles. From the Clinical Editor This article describes zeolite-based nanoparticles in generating time-controlled release of 5-FU from zeolite preparations for anti-cancer therapy.</description><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Caco-2 Cells</subject><subject>Cell Survival - drug effects</subject><subject>Controlled release</subject><subject>Cytocompatibility</subject><subject>Diffusion</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - chemistry</subject><subject>Fluorouracil - administration & dosage</subject><subject>Fluorouracil - chemistry</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kinetics</subject><subject>Molecular Dynamics Simulation</subject><subject>Molecular modeling</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasms - drug therapy</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Zeolites</subject><subject>Zeolites - administration & dosage</subject><subject>Zeolites - chemistry</subject><issn>1549-9634</issn><issn>1549-9642</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UUtLxDAYDKK46-of8CA9emnNo21SkAVZfMGCB_Uc0vQrZE2bNekK6683Zdc9ePCUj2FmmMwgdElwRjApb1ZZr3qXUUxYhsssQkdoSoq8Sqsyp8eHm-UTdBbCCmPGMa5O0YSyipRC8CmaL1w_eGctNIkHCypA4tqkSFu7cd5tvNLGJq13XdIZ7d16BEPyDc6aAcI5OmmVDXCxf2fo_eH-bfGULl8enxd3y1TnQgxpyQSrmiKmoiBanuc4RqMNFITGSJQJXNfxFnXBKWcs5y3GilMomYrpa8pm6Hrnu_bucwNhkJ0JGqxVPcQ8khSk5AWmXEQq3VFj2hA8tHLtTaf8VhIsx97kSo69ybE3iUsZoSi62vtv6g6ag-S3qEi43REg_vLLgJdBG-g1NMaDHmTjzP_-8z9ybU1vtLIfsIWwikX3sT9JZKASy9dxuXE4wuJoBWXsB1d8kU0</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Spanakis, Marios, PhD</creator><creator>Bouropoulos, Nikolaos, PhD</creator><creator>Theodoropoulos, Dimitrios, MSc</creator><creator>Sygellou, Lamprini, PhD</creator><creator>Ewart, Sinead, MSc</creator><creator>Moschovi, Anastasia Maria, PhD</creator><creator>Siokou, Angeliki, PhD</creator><creator>Niopas, Ioannis, PhD</creator><creator>Kachrimanis, Kyriakos, PhD</creator><creator>Nikolakis, Vladimiros, PhD</creator><creator>Cox, Paul A., PhD</creator><creator>Vizirianakis, Ioannis S., PhD</creator><creator>Fatouros, Dimitrios G., PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2014</creationdate><title>Controlled release of 5-fluorouracil from microporous zeolites</title><author>Spanakis, Marios, PhD ; Bouropoulos, Nikolaos, PhD ; Theodoropoulos, Dimitrios, MSc ; Sygellou, Lamprini, PhD ; Ewart, Sinead, MSc ; Moschovi, Anastasia Maria, PhD ; Siokou, Angeliki, PhD ; Niopas, Ioannis, PhD ; Kachrimanis, Kyriakos, PhD ; Nikolakis, Vladimiros, PhD ; Cox, Paul A., PhD ; Vizirianakis, Ioannis S., PhD ; Fatouros, Dimitrios G., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-63839d56422e8f74401542de5123702380bb5128b57273347f00a72e63a634b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Caco-2 Cells</topic><topic>Cell Survival - drug effects</topic><topic>Controlled release</topic><topic>Cytocompatibility</topic><topic>Diffusion</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - chemistry</topic><topic>Fluorouracil - administration & dosage</topic><topic>Fluorouracil - chemistry</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kinetics</topic><topic>Molecular Dynamics Simulation</topic><topic>Molecular modeling</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasms - drug therapy</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Zeolites</topic><topic>Zeolites - administration & dosage</topic><topic>Zeolites - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spanakis, Marios, PhD</creatorcontrib><creatorcontrib>Bouropoulos, Nikolaos, PhD</creatorcontrib><creatorcontrib>Theodoropoulos, Dimitrios, MSc</creatorcontrib><creatorcontrib>Sygellou, Lamprini, PhD</creatorcontrib><creatorcontrib>Ewart, Sinead, MSc</creatorcontrib><creatorcontrib>Moschovi, Anastasia Maria, PhD</creatorcontrib><creatorcontrib>Siokou, Angeliki, PhD</creatorcontrib><creatorcontrib>Niopas, Ioannis, PhD</creatorcontrib><creatorcontrib>Kachrimanis, Kyriakos, PhD</creatorcontrib><creatorcontrib>Nikolakis, Vladimiros, PhD</creatorcontrib><creatorcontrib>Cox, Paul A., PhD</creatorcontrib><creatorcontrib>Vizirianakis, Ioannis S., PhD</creatorcontrib><creatorcontrib>Fatouros, Dimitrios G., PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Nanomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spanakis, Marios, PhD</au><au>Bouropoulos, Nikolaos, PhD</au><au>Theodoropoulos, Dimitrios, MSc</au><au>Sygellou, Lamprini, PhD</au><au>Ewart, Sinead, MSc</au><au>Moschovi, Anastasia Maria, PhD</au><au>Siokou, Angeliki, PhD</au><au>Niopas, Ioannis, PhD</au><au>Kachrimanis, Kyriakos, PhD</au><au>Nikolakis, Vladimiros, PhD</au><au>Cox, Paul A., PhD</au><au>Vizirianakis, Ioannis S., PhD</au><au>Fatouros, Dimitrios G., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled release of 5-fluorouracil from microporous zeolites</atitle><jtitle>Nanomedicine</jtitle><addtitle>Nanomedicine</addtitle><date>2014</date><risdate>2014</risdate><volume>10</volume><issue>1</issue><spage>197</spage><epage>205</epage><pages>197-205</pages><issn>1549-9634</issn><eissn>1549-9642</eissn><abstract>Abstract Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles. From the Clinical Editor This article describes zeolite-based nanoparticles in generating time-controlled release of 5-FU from zeolite preparations for anti-cancer therapy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23916887</pmid><doi>10.1016/j.nano.2013.06.016</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Caco-2 Cells Cell Survival - drug effects Controlled release Cytocompatibility Diffusion Drug Carriers - administration & dosage Drug Carriers - chemistry Fluorouracil - administration & dosage Fluorouracil - chemistry Humans Internal Medicine Kinetics Molecular Dynamics Simulation Molecular modeling Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasms - drug therapy Spectroscopy, Fourier Transform Infrared Zeolites Zeolites - administration & dosage Zeolites - chemistry |
| title | Controlled release of 5-fluorouracil from microporous zeolites |
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