p53 is involved in shrimp survival via its regulation roles on MnSOD and GPx in response to acute environmental stresses

The tumor suppressor gene p53 plays a critical role in safeguarding the integrity of genome in mammalian cells. It acts as a sequence-specific transcription factor. Once activated by a variety of cellular stresses, p53 transactivates downstream target genes, through which it regulates cell cycle and...

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Veröffentlicht in:	Comparative biochemistry and physiology. Toxicology & pharmacology 2014-01, Vol.159, p.38-51
Hauptverfasser:	Qian, Zhaoying, Liu, Tao, Liu, Qiao, He, Shulin, Liu, Yongjie, Hou, Fujun, Wang, Xianzong, Mi, Xiao, Cai, Chen, Liu, Xiaolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute environmental stresses Amino Acid Sequence Animals Antioxidants - metabolism Base Sequence Cadmium - pharmacology Cloning, Molecular Crustacea - drug effects Crustacea - genetics Crustacea - metabolism Cumulative mortalities Environment Enzymatic activities Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Hydrogen-Ion Concentration Litopenaeus vannamei Marsupenaeus japonicus Molecular Sequence Data Oxidative Stress - drug effects Oxidative Stress - genetics p53 Phylogeny RNA interference (RNAi) RNA, Messenger - genetics Sequence Homology Stress, Physiological - drug effects Stress, Physiological - genetics Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Tissue distribution Transcription expression Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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