Replacement of the Saccharomyces cerevisiae acetyl-CoA synthetases by alternative pathways for cytosolic acetyl-CoA synthesis

Cytosolic acetyl-coenzyme A is a precursor for many biotechnologically relevant compounds produced by Saccharomyces cerevisiae. In this yeast, cytosolic acetyl-CoA synthesis and growth strictly depend on expression of either the Acs1 or Acs2 isoenzyme of acetyl-CoA synthetase (ACS). Since hydrolysis...

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Veröffentlicht in:	Metabolic engineering 2014-01, Vol.21, p.46-59
Hauptverfasser:	Kozak, Barbara U., van Rossum, Harmen M., Benjamin, Kirsten R., Wu, Liang, Daran, Jean-Marc G., Pronk, Jack T., van Maris, Antonius J.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetate-CoA Ligase - biosynthesis Acetate-CoA Ligase - genetics Acetyl Coenzyme A - biosynthesis Acetyl Coenzyme A - genetics Acetylating acetaldehyde dehydrogenase Acetyltransferases - biosynthesis Acetyltransferases - genetics Aldehyde Oxidoreductases - biosynthesis Aldehyde Oxidoreductases - genetics Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Cytosol - enzymology Metabolic compartments Precursor supply Pyruvate-formate lyase Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - biosynthesis Saccharomyces cerevisiae Proteins - genetics Transcriptome Yeast
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