Rugulactone derivatives act as inhibitors of NF-κB activation and modulates the transcription of NF-κB dependent genes in MDA-MB-231cells

Rugulactone and its analogues were synthesized following Horners-Wadsworth-Emmons and ring-closing metathesis as the key reactions. A library of new rugulactone analogues were designed, synthesized and evaluated for their anticancer activity in breast cancer cells. All analogues have shown anti-prol...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-03, Vol.24 (5), p.1389-1396
Hauptverfasser:	Mohapatra, Debendra K, Reddy, D Sai, Ramaiah, M Janaki, Ghosh, Sowjanya, Pothula, Vikram, Lunavath, Swetha, Thomas, Shine, Valli, S N C V L Pushpa, Bhadra, Manika Pal, Yadav, Jhillu S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology bcl-X Protein - metabolism Cell Line, Tumor Cell Survival - drug effects Cyclin E - metabolism Cyclin-Dependent Kinase 2 - metabolism Cyclin-Dependent Kinase Inhibitor p27 - genetics Cyclin-Dependent Kinase Inhibitor p27 - metabolism G1 Phase Cell Cycle Checkpoints - drug effects Humans Lactones - chemical synthesis Lactones - chemistry Lactones - pharmacology MCF-7 Cells NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Oncogene Proteins - metabolism Poly(ADP-ribose) Polymerases - metabolism Structure-Activity Relationship Transcription, Genetic - drug effects
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