The association of alcohol consumption and smoking with quality of life, disability and disease activity in an international sample of people with multiple sclerosis

Abstract Background Modifiable lifestyle factors represent important targets for preventive intervention in multiple sclerosis (MS). We aimed to explore the association of cigarette smoking and alcohol consumption with major MS morbidity outcomes. Methods We surveyed a large, international sample of...

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Veröffentlicht in:Journal of the neurological sciences 2014-01, Vol.336 (1), p.211-219
Hauptverfasser: Weiland, Tracey J, Hadgkiss, Emily J, Jelinek, George A, Pereira, Naresh G, Marck, Claudia H, van der Meer, Dania M
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container_end_page 219
container_issue 1
container_start_page 211
container_title Journal of the neurological sciences
container_volume 336
creator Weiland, Tracey J
Hadgkiss, Emily J
Jelinek, George A
Pereira, Naresh G
Marck, Claudia H
van der Meer, Dania M
description Abstract Background Modifiable lifestyle factors represent important targets for preventive intervention in multiple sclerosis (MS). We aimed to explore the association of cigarette smoking and alcohol consumption with major MS morbidity outcomes. Methods We surveyed a large, international sample of people with MS recruited via Web 2.0 platforms about type of MS, relapse rates, disability, disease activity, health-related quality of life (HRQOL), alcohol use and smoking. Results Of 2469 respondents with confirmed MS, 11.7% were current and 40.3% former smokers. Most (61.5%) consumed less than 15 g alcohol weekly; few (0.8%) drank large amounts. Moderate alcohol consumption was associated with increased HRQOL; and after controlling for age and gender, was associated with lower odds of significant disability (41% decrease). After controlling for age, gender and alcohol use, smokers had an increased likelihood of major mobility requirements by 90% compared to never smokers. There was no association between alcohol or smoking and relapse rate or disease activity after controlling for age and gender, however among former smokers, a longer duration of smoking cessation was associated with reduced disease activity. Smokers had significantly lower HRQOL than never smokers and former smokers; heavier smoking was associated with greater decreases in HRQOL. Conclusion This cross-sectional study supports previous research showing a link between morbidity indicators in MS and alcohol use and smoking. While people with MS should be advised of the potential risks of smoking, any risks and benefits of alcohol consumption require validation using a prospective cohort of people with MS.
doi_str_mv 10.1016/j.jns.2013.10.046
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We aimed to explore the association of cigarette smoking and alcohol consumption with major MS morbidity outcomes. Methods We surveyed a large, international sample of people with MS recruited via Web 2.0 platforms about type of MS, relapse rates, disability, disease activity, health-related quality of life (HRQOL), alcohol use and smoking. Results Of 2469 respondents with confirmed MS, 11.7% were current and 40.3% former smokers. Most (61.5%) consumed less than 15 g alcohol weekly; few (0.8%) drank large amounts. Moderate alcohol consumption was associated with increased HRQOL; and after controlling for age and gender, was associated with lower odds of significant disability (41% decrease). After controlling for age, gender and alcohol use, smokers had an increased likelihood of major mobility requirements by 90% compared to never smokers. There was no association between alcohol or smoking and relapse rate or disease activity after controlling for age and gender, however among former smokers, a longer duration of smoking cessation was associated with reduced disease activity. Smokers had significantly lower HRQOL than never smokers and former smokers; heavier smoking was associated with greater decreases in HRQOL. Conclusion This cross-sectional study supports previous research showing a link between morbidity indicators in MS and alcohol use and smoking. While people with MS should be advised of the potential risks of smoking, any risks and benefits of alcohol consumption require validation using a prospective cohort of people with MS.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2013.10.046</identifier><identifier>PMID: 24290614</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alcohol ; Alcohol Drinking - epidemiology ; Alcohol Drinking - psychology ; Cross-Sectional Studies ; Data Collection - methods ; Disability ; Disabled Persons - psychology ; Disease Progression ; Female ; Humans ; Internationality ; Life Style ; Male ; Multiple sclerosis ; Multiple Sclerosis - epidemiology ; Multiple Sclerosis - psychology ; Neurology ; Quality of life ; Quality of Life - psychology ; Relapse ; Smoking ; Smoking - epidemiology ; Smoking - psychology ; Survey</subject><ispartof>Journal of the neurological sciences, 2014-01, Vol.336 (1), p.211-219</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-d138ff47fa4cb011ea92944375e0eeacb618320dd861ae4bf5798e310d193cf63</citedby><cites>FETCH-LOGICAL-c441t-d138ff47fa4cb011ea92944375e0eeacb618320dd861ae4bf5798e310d193cf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2013.10.046$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24290614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weiland, Tracey J</creatorcontrib><creatorcontrib>Hadgkiss, Emily J</creatorcontrib><creatorcontrib>Jelinek, George A</creatorcontrib><creatorcontrib>Pereira, Naresh G</creatorcontrib><creatorcontrib>Marck, Claudia H</creatorcontrib><creatorcontrib>van der Meer, Dania M</creatorcontrib><title>The association of alcohol consumption and smoking with quality of life, disability and disease activity in an international sample of people with multiple sclerosis</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Abstract Background Modifiable lifestyle factors represent important targets for preventive intervention in multiple sclerosis (MS). We aimed to explore the association of cigarette smoking and alcohol consumption with major MS morbidity outcomes. Methods We surveyed a large, international sample of people with MS recruited via Web 2.0 platforms about type of MS, relapse rates, disability, disease activity, health-related quality of life (HRQOL), alcohol use and smoking. Results Of 2469 respondents with confirmed MS, 11.7% were current and 40.3% former smokers. Most (61.5%) consumed less than 15 g alcohol weekly; few (0.8%) drank large amounts. Moderate alcohol consumption was associated with increased HRQOL; and after controlling for age and gender, was associated with lower odds of significant disability (41% decrease). After controlling for age, gender and alcohol use, smokers had an increased likelihood of major mobility requirements by 90% compared to never smokers. There was no association between alcohol or smoking and relapse rate or disease activity after controlling for age and gender, however among former smokers, a longer duration of smoking cessation was associated with reduced disease activity. Smokers had significantly lower HRQOL than never smokers and former smokers; heavier smoking was associated with greater decreases in HRQOL. Conclusion This cross-sectional study supports previous research showing a link between morbidity indicators in MS and alcohol use and smoking. While people with MS should be advised of the potential risks of smoking, any risks and benefits of alcohol consumption require validation using a prospective cohort of people with MS.</description><subject>Alcohol</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol Drinking - psychology</subject><subject>Cross-Sectional Studies</subject><subject>Data Collection - methods</subject><subject>Disability</subject><subject>Disabled Persons - psychology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Internationality</subject><subject>Life Style</subject><subject>Male</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Multiple Sclerosis - psychology</subject><subject>Neurology</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Relapse</subject><subject>Smoking</subject><subject>Smoking - epidemiology</subject><subject>Smoking - psychology</subject><subject>Survey</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEokvhAbigHDmwy0zsJI6QkKqKf1IlDhSJm-V1JqxTJ95mkqJ9IN4Te7dw4AAX2_Ppm581_pxlzxE2CFi97jf9yJsCUMR6A7J6kK1Q1WpdKiUeZiuAoliXCN_OsifMPQBUSjWPs7NCFg1UKFfZz-sd5YY5WGdmF8Y8dLnxNuyCz20YeRn2R9mMbc5DuHHj9_yHm3f57WK8mw_J711Hr_LWsdm6o5bMsSTDkW1nd5dElyBxnWkaj1cZn7MZ9p4SY08hnY7oYfGzSxVbT1Ngx0-zR53xTM_u9_Ps6_t315cf11efP3y6vLhaWylxXrcoVNfJujPSbgGRTFM0Uoq6JCAydluhEgW0rarQkNx2Zd0oEggtNsJ2lTjPXp64-yncLsSzHhxb8t6MFBbWWGJVy0bUxf-tsoG6rrFKVjxZbRyGJ-r0fnKDmQ4aQacgda9jkDoFmaQYZOx5cY9ftgO1fzp-JxcNb04Giu9x52jSbB2Nllo3kZ11G9w_8W__6rbejc4af0MH4j4sMSQfp9BcaNBf0k9KHwkFCABViV8w9sb0</recordid><startdate>20140115</startdate><enddate>20140115</enddate><creator>Weiland, Tracey J</creator><creator>Hadgkiss, Emily J</creator><creator>Jelinek, George A</creator><creator>Pereira, Naresh G</creator><creator>Marck, Claudia H</creator><creator>van der Meer, Dania M</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20140115</creationdate><title>The association of alcohol consumption and smoking with quality of life, disability and disease activity in an international sample of people with multiple sclerosis</title><author>Weiland, Tracey J ; Hadgkiss, Emily J ; Jelinek, George A ; Pereira, Naresh G ; Marck, Claudia H ; van der Meer, Dania M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-d138ff47fa4cb011ea92944375e0eeacb618320dd861ae4bf5798e310d193cf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alcohol</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol Drinking - psychology</topic><topic>Cross-Sectional Studies</topic><topic>Data Collection - methods</topic><topic>Disability</topic><topic>Disabled Persons - psychology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Internationality</topic><topic>Life Style</topic><topic>Male</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - epidemiology</topic><topic>Multiple Sclerosis - psychology</topic><topic>Neurology</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Relapse</topic><topic>Smoking</topic><topic>Smoking - epidemiology</topic><topic>Smoking - psychology</topic><topic>Survey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weiland, Tracey J</creatorcontrib><creatorcontrib>Hadgkiss, Emily J</creatorcontrib><creatorcontrib>Jelinek, George A</creatorcontrib><creatorcontrib>Pereira, Naresh G</creatorcontrib><creatorcontrib>Marck, Claudia H</creatorcontrib><creatorcontrib>van der Meer, Dania M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiland, Tracey J</au><au>Hadgkiss, Emily J</au><au>Jelinek, George A</au><au>Pereira, Naresh G</au><au>Marck, Claudia H</au><au>van der Meer, Dania M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of alcohol consumption and smoking with quality of life, disability and disease activity in an international sample of people with multiple sclerosis</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2014-01-15</date><risdate>2014</risdate><volume>336</volume><issue>1</issue><spage>211</spage><epage>219</epage><pages>211-219</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>Abstract Background Modifiable lifestyle factors represent important targets for preventive intervention in multiple sclerosis (MS). We aimed to explore the association of cigarette smoking and alcohol consumption with major MS morbidity outcomes. Methods We surveyed a large, international sample of people with MS recruited via Web 2.0 platforms about type of MS, relapse rates, disability, disease activity, health-related quality of life (HRQOL), alcohol use and smoking. Results Of 2469 respondents with confirmed MS, 11.7% were current and 40.3% former smokers. Most (61.5%) consumed less than 15 g alcohol weekly; few (0.8%) drank large amounts. Moderate alcohol consumption was associated with increased HRQOL; and after controlling for age and gender, was associated with lower odds of significant disability (41% decrease). After controlling for age, gender and alcohol use, smokers had an increased likelihood of major mobility requirements by 90% compared to never smokers. There was no association between alcohol or smoking and relapse rate or disease activity after controlling for age and gender, however among former smokers, a longer duration of smoking cessation was associated with reduced disease activity. Smokers had significantly lower HRQOL than never smokers and former smokers; heavier smoking was associated with greater decreases in HRQOL. Conclusion This cross-sectional study supports previous research showing a link between morbidity indicators in MS and alcohol use and smoking. While people with MS should be advised of the potential risks of smoking, any risks and benefits of alcohol consumption require validation using a prospective cohort of people with MS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24290614</pmid><doi>10.1016/j.jns.2013.10.046</doi><tpages>9</tpages></addata></record>
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subjects Alcohol
Alcohol Drinking - epidemiology
Alcohol Drinking - psychology
Cross-Sectional Studies
Data Collection - methods
Disability
Disabled Persons - psychology
Disease Progression
Female
Humans
Internationality
Life Style
Male
Multiple sclerosis
Multiple Sclerosis - epidemiology
Multiple Sclerosis - psychology
Neurology
Quality of life
Quality of Life - psychology
Relapse
Smoking
Smoking - epidemiology
Smoking - psychology
Survey
title The association of alcohol consumption and smoking with quality of life, disability and disease activity in an international sample of people with multiple sclerosis
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