Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats
Abstract Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divide...
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| Veröffentlicht in: | Neuropeptides (Edinburgh) 2013-10, Vol.47 (5), p.355-360 |
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| creator | Babri, Shirin Amani, Mohammad Mohaddes, Gisou Mirzaei, Fariba Mahmoudi, Fariba |
| description | Abstract Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including control, saline, ghrelin (0.3, 1.5 or 3 nmol) and pentylenetetrazol (PTZ, 50 mg/kg, i.p.) plus saline or ghrelin (0.3, 1.5 or 3 nmol). All groups were trained in Morris water maze (MWM) for two consecutive days. Our results showed that ghrelin significantly improves spatial memory at the doses of 1.5 or 3 nmol ( P < 0.05) in normal rats. We also demonstrated the significant impairment of spatial memory in PTZ group ( P < 0.05). Intrahippocampal injection of ghrelin at the dose of 3 nmol significantly improved spatial memory in PTZ + gh group compared to PTZ group ( P < 0.05). These findings suggest that ghrelin as a neuropeptide can improve spatial memory in PTZ-treated rats. |
| doi_str_mv | 10.1016/j.npep.2013.05.005 |
| format | Article |
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There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including control, saline, ghrelin (0.3, 1.5 or 3 nmol) and pentylenetetrazol (PTZ, 50 mg/kg, i.p.) plus saline or ghrelin (0.3, 1.5 or 3 nmol). All groups were trained in Morris water maze (MWM) for two consecutive days. Our results showed that ghrelin significantly improves spatial memory at the doses of 1.5 or 3 nmol ( P < 0.05) in normal rats. We also demonstrated the significant impairment of spatial memory in PTZ group ( P < 0.05). Intrahippocampal injection of ghrelin at the dose of 3 nmol significantly improved spatial memory in PTZ + gh group compared to PTZ group ( P < 0.05). These findings suggest that ghrelin as a neuropeptide can improve spatial memory in PTZ-treated rats.</description><identifier>ISSN: 0143-4179</identifier><identifier>EISSN: 1532-2785</identifier><identifier>DOI: 10.1016/j.npep.2013.05.005</identifier><identifier>PMID: 23790400</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Animals ; Convulsants ; Disease Models, Animal ; Endocrinology & Metabolism ; Ghrelin ; Ghrelin - administration & dosage ; Ghrelin - pharmacology ; Hippocampus ; Hippocampus - drug effects ; Injections ; Learning ; Male ; Maze Learning - drug effects ; Memory - drug effects ; Morris water maze ; Pentylenetetrazol (PTZ) ; Pentylenetetrazole ; Rats ; Rats, Wistar ; Seizures - chemically induced ; Seizures - physiopathology ; Spatial Behavior - drug effects ; Spatial memory</subject><ispartof>Neuropeptides (Edinburgh), 2013-10, Vol.47 (5), p.355-360</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-bdab02dd2bda2824f22c1d559e19114e534bca57495823b284251f211cb8b8e13</citedby><cites>FETCH-LOGICAL-c477t-bdab02dd2bda2824f22c1d559e19114e534bca57495823b284251f211cb8b8e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0143417913000413$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23790400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babri, Shirin</creatorcontrib><creatorcontrib>Amani, Mohammad</creatorcontrib><creatorcontrib>Mohaddes, Gisou</creatorcontrib><creatorcontrib>Mirzaei, Fariba</creatorcontrib><creatorcontrib>Mahmoudi, Fariba</creatorcontrib><title>Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats</title><title>Neuropeptides (Edinburgh)</title><addtitle>Neuropeptides</addtitle><description>Abstract Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including control, saline, ghrelin (0.3, 1.5 or 3 nmol) and pentylenetetrazol (PTZ, 50 mg/kg, i.p.) plus saline or ghrelin (0.3, 1.5 or 3 nmol). All groups were trained in Morris water maze (MWM) for two consecutive days. Our results showed that ghrelin significantly improves spatial memory at the doses of 1.5 or 3 nmol ( P < 0.05) in normal rats. We also demonstrated the significant impairment of spatial memory in PTZ group ( P < 0.05). Intrahippocampal injection of ghrelin at the dose of 3 nmol significantly improved spatial memory in PTZ + gh group compared to PTZ group ( P < 0.05). These findings suggest that ghrelin as a neuropeptide can improve spatial memory in PTZ-treated rats.</description><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Convulsants</subject><subject>Disease Models, Animal</subject><subject>Endocrinology & Metabolism</subject><subject>Ghrelin</subject><subject>Ghrelin - administration & dosage</subject><subject>Ghrelin - pharmacology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Injections</subject><subject>Learning</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Memory - drug effects</subject><subject>Morris water maze</subject><subject>Pentylenetetrazol (PTZ)</subject><subject>Pentylenetetrazole</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seizures - chemically induced</subject><subject>Seizures - physiopathology</subject><subject>Spatial Behavior - drug effects</subject><subject>Spatial memory</subject><issn>0143-4179</issn><issn>1532-2785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2L1kAMgAdR3NfVP-BBevTSmsxHOwURZFk_YEHB9eJlmE7T3an9cqYVXn-9U97Vgwf1lJA8ySFPGHuKUCBg-aIvpoWWggOKAlQBoO6xAyrBc15pdZ8dAKXIJVb1GXsUYw8Akmv9kJ1xUdUgAQ7s5rLryK0xm7vMT2uwt35ZZmfHxQ6p0Keen6e9e3MbaPApnbK42NWn_kjjHI4Jyz5ef8n91G6O2iyS_7EFint9tANlwa7xMXvQ2SHSk7t4zj6_uby-eJdffXj7_uL1Ve5kVa1509oGeNvylHDNZce5w1apmrBGlKSEbJxVlayV5qLhWnKFHUd0jW40oThnz097lzB_2yiuZvTR0TDYieYtGlRYVlKrGv6NypqXWHLQ_4HubKnLKqH8hLowxxioM0vwow1Hg2B2baY3uzazazOgTNKWhp7d7d-akdrfI788JeDlCaB0u--egonO05TO7UNSZNrZ_33_qz_GXVLpnR2-0pFiP29hSlYMmsgNmE_74-x_g2L_GRTiJ8LsvRI</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Babri, Shirin</creator><creator>Amani, Mohammad</creator><creator>Mohaddes, Gisou</creator><creator>Mirzaei, Fariba</creator><creator>Mahmoudi, Fariba</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20131001</creationdate><title>Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats</title><author>Babri, Shirin ; Amani, Mohammad ; Mohaddes, Gisou ; Mirzaei, Fariba ; Mahmoudi, Fariba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-bdab02dd2bda2824f22c1d559e19114e534bca57495823b284251f211cb8b8e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Convulsants</topic><topic>Disease Models, Animal</topic><topic>Endocrinology & Metabolism</topic><topic>Ghrelin</topic><topic>Ghrelin - administration & dosage</topic><topic>Ghrelin - pharmacology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Injections</topic><topic>Learning</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Memory - drug effects</topic><topic>Morris water maze</topic><topic>Pentylenetetrazol (PTZ)</topic><topic>Pentylenetetrazole</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seizures - chemically induced</topic><topic>Seizures - physiopathology</topic><topic>Spatial Behavior - drug effects</topic><topic>Spatial memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babri, Shirin</creatorcontrib><creatorcontrib>Amani, Mohammad</creatorcontrib><creatorcontrib>Mohaddes, Gisou</creatorcontrib><creatorcontrib>Mirzaei, Fariba</creatorcontrib><creatorcontrib>Mahmoudi, Fariba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuropeptides (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babri, Shirin</au><au>Amani, Mohammad</au><au>Mohaddes, Gisou</au><au>Mirzaei, Fariba</au><au>Mahmoudi, Fariba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats</atitle><jtitle>Neuropeptides (Edinburgh)</jtitle><addtitle>Neuropeptides</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>47</volume><issue>5</issue><spage>355</spage><epage>360</epage><pages>355-360</pages><issn>0143-4179</issn><eissn>1532-2785</eissn><abstract>Abstract Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including control, saline, ghrelin (0.3, 1.5 or 3 nmol) and pentylenetetrazol (PTZ, 50 mg/kg, i.p.) plus saline or ghrelin (0.3, 1.5 or 3 nmol). All groups were trained in Morris water maze (MWM) for two consecutive days. Our results showed that ghrelin significantly improves spatial memory at the doses of 1.5 or 3 nmol ( P < 0.05) in normal rats. We also demonstrated the significant impairment of spatial memory in PTZ group ( P < 0.05). Intrahippocampal injection of ghrelin at the dose of 3 nmol significantly improved spatial memory in PTZ + gh group compared to PTZ group ( P < 0.05). These findings suggest that ghrelin as a neuropeptide can improve spatial memory in PTZ-treated rats.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>23790400</pmid><doi>10.1016/j.npep.2013.05.005</doi><tpages>6</tpages></addata></record> |
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| subjects | Advanced Basic Science Animals Convulsants Disease Models, Animal Endocrinology & Metabolism Ghrelin Ghrelin - administration & dosage Ghrelin - pharmacology Hippocampus Hippocampus - drug effects Injections Learning Male Maze Learning - drug effects Memory - drug effects Morris water maze Pentylenetetrazol (PTZ) Pentylenetetrazole Rats Rats, Wistar Seizures - chemically induced Seizures - physiopathology Spatial Behavior - drug effects Spatial memory |
| title | Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats |
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