A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp: e90766

Mis-sense mutations in the alpha -subunit of the G-protein, Gs alpha , cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these mutations is constitutively active Gs alpha and increased levels of cAMP. The aim of this study was to develop an assay system that would...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3)
Hauptverfasser:	Bhattacharyya, Nisan, Hu, Xin, Chen, Catherine Z, Griner, Lesley AMathews, Zheng, Wei, Inglese, James, Austin, Christopher P, Marugan, Juan J, Southall, Noel, Neumann, Susanne
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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