Ischemic preconditioning-induced neuroprotection against transient cerebral ischemic damage via attenuating ubiquitin aggregation

Abstract Ubiquitin binds to short-lived proteins, and denatured proteins are produced by various forms of injuries. In the present study, we investigated the effect of ischemic preconditioning (IPC) on free ubiquitin and its mutant form (ubiquitin + 1 ) in the gerbil hippocampus induced by transient...

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Veröffentlicht in:	Journal of the neurological sciences 2014-01, Vol.336 (1), p.74-82
Hauptverfasser:	Lee, Jae-Chul, Kim, In Hye, Cho, Geum-Sil, Park, Joon Ha, Ahn, Ji Hyeon, Yan, Bing Chun, Kwon, Hyuk Min, Kim, Young-Myeong, Cheon, Seung Hwan, Cho, Jun Hwi, Lee, Hui Young, Won, Moo-Ho, Seo, Jeong Yeol
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Delayed neuronal death Gerbillinae Hippocampus Ischemia–reperfusion Ischemic Attack, Transient - metabolism Ischemic Attack, Transient - pathology Ischemic Attack, Transient - prevention & control Ischemic preconditioning Ischemic Preconditioning - methods Male Neurology Neuroprotective Agents - metabolism Pyramidal Cells - metabolism Pyramidal Cells - pathology Pyramidal neurons Ubiquitin - antagonists & inhibitors Ubiquitin - metabolism Ubiquitin system
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