Cholinesterase inhibitory activity versus aromatic core multiplicity: A facile green synthesis and molecular docking study of novel piperidone embedded thiazolopyrimidines

Novel piperidone grafted heterocycles comprising three aromatic core synthesized and evaluated for cholinesterases inhibitory activity to disclose the relationship between the activity and aromatic content of inhibitors. Novel thiazolopyrimidine derivatives have been synthesized via microwave assist...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2014-01, Vol.22 (2), p.906-916
Hauptverfasser:	Basiri, Alireza, Murugaiyah, Vikneswaran, Osman, Hasnah, Kumar, Raju Suresh, Kia, Yalda, Hooda, Alysha, Parsons, Richard B.
Format:	Artikel
Sprache:	eng
Schlagworte:	AChE and BChE inhibitory activity Aromatic core multiplicity Butyrylcholinesterase - metabolism Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Cholinesterases - metabolism Domino cascade synthesis Dose-Response Relationship, Drug Green Chemistry Technology Humans Ionic liquids Molecular Docking Simulation Molecular modeling Molecular Structure Piperidones - chemistry Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Structure-Activity Relationship Thiazolopyrimidines
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