New non-symmetrical choline kinase inhibitors

Identification of novel and selective anticancer agents remains an important and challenging goal in pharmacological research. Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine (PC), the major phospholipid in eukaryotic cell membranes. In the p...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-11, Vol.21 (22), p.7146-7154
Hauptverfasser:	Schiaffino-Ortega, Santiago, López-Cara, Luisa Carlota, Ríos-Marco, Pablo, Carrasco-Jimenez, Maria Paz, Gallo, Miguel A., Espinosa, Antonio, Marco, Carmen, Entrena, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Aminophenol aminophenols antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Binding Sites cell membranes Cell Proliferation - drug effects chemistry Choline kinase Choline Kinase - antagonists & inhibitors Choline Kinase - metabolism Docking studies Drug Design Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism eukaryotic cells Hemicholinium 3 - chemistry Hep G2 Cells Humans Inhibitors Molecular Docking Simulation phosphatidylcholines Protein Binding Protein Structure, Tertiary Zea
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