The kinin B1 receptor mediates alloknesis in a murine model of inflammation
•Non-noxious mechanical stimulus elicits itch in skin inflamed by complete Freund's adjuvant.•Subcutaneous naltrexone reduces alloknesis score.•Premedication with kinin B1 receptor antagonist reduces alloknesis score.•Premedication with kinin B2 receptor antagonist increases alloknesis score. N...
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| Veröffentlicht in: | Neuroscience letters 2014-02, Vol.560, p.31-35 |
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| creator | Feng, Jumian Chen, Yuanzhen Xiong, Jialing Chen, Xu Liang, Jiexian Ji, Wenjin |
| description | •Non-noxious mechanical stimulus elicits itch in skin inflamed by complete Freund's adjuvant.•Subcutaneous naltrexone reduces alloknesis score.•Premedication with kinin B1 receptor antagonist reduces alloknesis score.•Premedication with kinin B2 receptor antagonist increases alloknesis score.
Noxious stimuli and non-noxious mechanical stimuli elicit itch (alloknesis) instead of pain on skin lesions of patients with atopic dermatitis. We previously found that bradykinin evokes an itch-related scratching response through activation of kinin B1 receptor in skin inflamed using complete Freund's adjuvant. In this study we investigated whether alloknesis is evoked in CFA-inflamed skin and the involvement of kinin receptors. In our results, alloknesis was elicited four days after CFA-inflammation. Furthermore, pretreatment with a B1 receptor antagonist or μ-opioid receptor antagonist significantly reduced alloknesis. In contrast, treatment with a B2 receptor antagonist significantly increased alloknesis. These results suggest that the alloknesis response is mediated by the activation of kinin B1 receptor but antagonized by the B2 receptor in CFA-inflamed mice. |
| doi_str_mv | 10.1016/j.neulet.2013.12.014 |
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Noxious stimuli and non-noxious mechanical stimuli elicit itch (alloknesis) instead of pain on skin lesions of patients with atopic dermatitis. We previously found that bradykinin evokes an itch-related scratching response through activation of kinin B1 receptor in skin inflamed using complete Freund's adjuvant. In this study we investigated whether alloknesis is evoked in CFA-inflamed skin and the involvement of kinin receptors. In our results, alloknesis was elicited four days after CFA-inflammation. Furthermore, pretreatment with a B1 receptor antagonist or μ-opioid receptor antagonist significantly reduced alloknesis. In contrast, treatment with a B2 receptor antagonist significantly increased alloknesis. These results suggest that the alloknesis response is mediated by the activation of kinin B1 receptor but antagonized by the B2 receptor in CFA-inflamed mice.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2013.12.014</identifier><identifier>PMID: 24355361</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Alloknesis ; Animals ; Bradykinin - pharmacology ; Bradykinin B1 Receptor Antagonists ; Bradykinin B2 Receptor Antagonists ; Complete Freund's adjuvant ; Dermatitis - etiology ; Dermatitis - metabolism ; Dermatitis - physiopathology ; Freund's Adjuvant ; Inflammation ; Itch ; Kinin B1 receptor ; Male ; Mice, Inbred C57BL ; Physical Stimulation ; Pruritus - etiology ; Pruritus - metabolism ; Pruritus - physiopathology ; Receptor, Bradykinin B1 - metabolism ; Receptor, Bradykinin B2 - metabolism ; Receptors, Opioid, mu - antagonists & inhibitors ; Skin - metabolism ; Touch</subject><ispartof>Neuroscience letters, 2014-02, Vol.560, p.31-35</ispartof><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-8469f3191192edb9cafe12ab23fc14c7173c3b5a5a34d657faa5d12cff15cbbd3</citedby><cites>FETCH-LOGICAL-c310t-8469f3191192edb9cafe12ab23fc14c7173c3b5a5a34d657faa5d12cff15cbbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2013.12.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24355361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Jumian</creatorcontrib><creatorcontrib>Chen, Yuanzhen</creatorcontrib><creatorcontrib>Xiong, Jialing</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Liang, Jiexian</creatorcontrib><creatorcontrib>Ji, Wenjin</creatorcontrib><title>The kinin B1 receptor mediates alloknesis in a murine model of inflammation</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>•Non-noxious mechanical stimulus elicits itch in skin inflamed by complete Freund's adjuvant.•Subcutaneous naltrexone reduces alloknesis score.•Premedication with kinin B1 receptor antagonist reduces alloknesis score.•Premedication with kinin B2 receptor antagonist increases alloknesis score.
Noxious stimuli and non-noxious mechanical stimuli elicit itch (alloknesis) instead of pain on skin lesions of patients with atopic dermatitis. We previously found that bradykinin evokes an itch-related scratching response through activation of kinin B1 receptor in skin inflamed using complete Freund's adjuvant. In this study we investigated whether alloknesis is evoked in CFA-inflamed skin and the involvement of kinin receptors. In our results, alloknesis was elicited four days after CFA-inflammation. Furthermore, pretreatment with a B1 receptor antagonist or μ-opioid receptor antagonist significantly reduced alloknesis. In contrast, treatment with a B2 receptor antagonist significantly increased alloknesis. These results suggest that the alloknesis response is mediated by the activation of kinin B1 receptor but antagonized by the B2 receptor in CFA-inflamed mice.</description><subject>Alloknesis</subject><subject>Animals</subject><subject>Bradykinin - pharmacology</subject><subject>Bradykinin B1 Receptor Antagonists</subject><subject>Bradykinin B2 Receptor Antagonists</subject><subject>Complete Freund's adjuvant</subject><subject>Dermatitis - etiology</subject><subject>Dermatitis - metabolism</subject><subject>Dermatitis - physiopathology</subject><subject>Freund's Adjuvant</subject><subject>Inflammation</subject><subject>Itch</subject><subject>Kinin B1 receptor</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Physical Stimulation</subject><subject>Pruritus - etiology</subject><subject>Pruritus - metabolism</subject><subject>Pruritus - physiopathology</subject><subject>Receptor, Bradykinin B1 - metabolism</subject><subject>Receptor, Bradykinin B2 - metabolism</subject><subject>Receptors, Opioid, mu - antagonists & inhibitors</subject><subject>Skin - metabolism</subject><subject>Touch</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1r3DAQgGERGpLNtv-gBB1zsavRhxVfCm1o0pJALpuzkOUR1ca2NpJdyL-vlt30mJ4E4p0ZeAj5DKwGBs2XbT3hMuBccwaiBl4zkCdkBdeaV7rV_ANZMcFkJVrJzslFzlvGmAIlz8g5l0Ip0cCK3G9-I30OU5jod6AJHe7mmOiIfbAzZmqHIT5PmEOmJbF0XFKYkI6xx4FGXz79YMfRziFOH8mpt0PGT8d3TZ5uf2xuflYPj3e_br49VE4Am6tr2bReQAvQcuy71lmPwG3HhXcgnQYtnOiUVVbIvlHaW6t64M57UK7rerEmV4e9uxRfFsyzGUN2OAx2wrhkAwoaLbVk6v-pbHmj2z3hmshD6lLMOaE3uxRGm14NMLMXN1tzEDf73AA3RbyMXR4vLF1R-zf0RlyCr4cAC8mfgMlkF3ByRbhwz6aP4f0LfwHWnZNu</recordid><startdate>20140207</startdate><enddate>20140207</enddate><creator>Feng, Jumian</creator><creator>Chen, Yuanzhen</creator><creator>Xiong, Jialing</creator><creator>Chen, Xu</creator><creator>Liang, Jiexian</creator><creator>Ji, Wenjin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20140207</creationdate><title>The kinin B1 receptor mediates alloknesis in a murine model of inflammation</title><author>Feng, Jumian ; Chen, Yuanzhen ; Xiong, Jialing ; Chen, Xu ; Liang, Jiexian ; Ji, Wenjin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-8469f3191192edb9cafe12ab23fc14c7173c3b5a5a34d657faa5d12cff15cbbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alloknesis</topic><topic>Animals</topic><topic>Bradykinin - pharmacology</topic><topic>Bradykinin B1 Receptor Antagonists</topic><topic>Bradykinin B2 Receptor Antagonists</topic><topic>Complete Freund's adjuvant</topic><topic>Dermatitis - etiology</topic><topic>Dermatitis - metabolism</topic><topic>Dermatitis - physiopathology</topic><topic>Freund's Adjuvant</topic><topic>Inflammation</topic><topic>Itch</topic><topic>Kinin B1 receptor</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>Physical Stimulation</topic><topic>Pruritus - etiology</topic><topic>Pruritus - metabolism</topic><topic>Pruritus - physiopathology</topic><topic>Receptor, Bradykinin B1 - metabolism</topic><topic>Receptor, Bradykinin B2 - metabolism</topic><topic>Receptors, Opioid, mu - antagonists & inhibitors</topic><topic>Skin - metabolism</topic><topic>Touch</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Jumian</creatorcontrib><creatorcontrib>Chen, Yuanzhen</creatorcontrib><creatorcontrib>Xiong, Jialing</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Liang, Jiexian</creatorcontrib><creatorcontrib>Ji, Wenjin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Jumian</au><au>Chen, Yuanzhen</au><au>Xiong, Jialing</au><au>Chen, Xu</au><au>Liang, Jiexian</au><au>Ji, Wenjin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The kinin B1 receptor mediates alloknesis in a murine model of inflammation</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2014-02-07</date><risdate>2014</risdate><volume>560</volume><spage>31</spage><epage>35</epage><pages>31-35</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>•Non-noxious mechanical stimulus elicits itch in skin inflamed by complete Freund's adjuvant.•Subcutaneous naltrexone reduces alloknesis score.•Premedication with kinin B1 receptor antagonist reduces alloknesis score.•Premedication with kinin B2 receptor antagonist increases alloknesis score.
Noxious stimuli and non-noxious mechanical stimuli elicit itch (alloknesis) instead of pain on skin lesions of patients with atopic dermatitis. We previously found that bradykinin evokes an itch-related scratching response through activation of kinin B1 receptor in skin inflamed using complete Freund's adjuvant. In this study we investigated whether alloknesis is evoked in CFA-inflamed skin and the involvement of kinin receptors. In our results, alloknesis was elicited four days after CFA-inflammation. Furthermore, pretreatment with a B1 receptor antagonist or μ-opioid receptor antagonist significantly reduced alloknesis. In contrast, treatment with a B2 receptor antagonist significantly increased alloknesis. These results suggest that the alloknesis response is mediated by the activation of kinin B1 receptor but antagonized by the B2 receptor in CFA-inflamed mice.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>24355361</pmid><doi>10.1016/j.neulet.2013.12.014</doi><tpages>5</tpages></addata></record> |
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| subjects | Alloknesis Animals Bradykinin - pharmacology Bradykinin B1 Receptor Antagonists Bradykinin B2 Receptor Antagonists Complete Freund's adjuvant Dermatitis - etiology Dermatitis - metabolism Dermatitis - physiopathology Freund's Adjuvant Inflammation Itch Kinin B1 receptor Male Mice, Inbred C57BL Physical Stimulation Pruritus - etiology Pruritus - metabolism Pruritus - physiopathology Receptor, Bradykinin B1 - metabolism Receptor, Bradykinin B2 - metabolism Receptors, Opioid, mu - antagonists & inhibitors Skin - metabolism Touch |
| title | The kinin B1 receptor mediates alloknesis in a murine model of inflammation |
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