Synthesis and biological evaluation of new boron-containing chlorin derivatives as agents for both photodynamic therapy and boron neutron capture therapy of cancer

New boron-containing chlorin derivatives 9 and 13 as agents for both photodynamic therapy (PDT) and boron neutron capture therapy (BNCT) of cancer were synthesized from photoprotoporphyrin IX dimethyl ester (2) and L-4-boronophenylalanine-related compounds. The in vivo biodistribution and clearance...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-03, Vol.24 (5), p.1339-1343
Hauptverfasser:	Asano, Ryuji, Nagami, Amon, Fukumoto, Yuki, Miura, Kaori, Yazama, Futoshi, Ito, Hideyuki, Sakata, Isao, Tai, Akihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Boron - chemistry Boron Neutron Capture Therapy Boronic Acids - chemical synthesis Boronic Acids - chemistry Boronic Acids - pharmacology Cell Proliferation - drug effects Light Mice Mice, Inbred BALB C Neoplasms - radiotherapy Photochemotherapy Photosensitizing Agents - chemical synthesis Photosensitizing Agents - pharmacokinetics Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Porphyrins - chemical synthesis Porphyrins - chemistry Porphyrins - pharmacokinetics Porphyrins - pharmacology Porphyrins - therapeutic use Tissue Distribution
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