Bovine serum albumin nanoparticle vaccine reduces lung pathology induced by live Pseudomonas aeruginosa infection in mice

Highlights • A nanoparticle associated to P. aeruginosa antigens is proposed as a new vaccine. • The immunized mice showed a significant production of anti P. aeruginosa antibodies. • The immunized mice had a less lung tissue damage induced by live P. aeruginosa.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2013-10, Vol.31 (44), p.5062-5066
Hauptverfasser:	Rodrigues, Naiara Ferreira, van Tilburg Bernardes, Erik, Rocha, Raissa Prado, da Costa, Lauro César Felipe, Coutinho, Ana Carolina Amaral, dos Santos Muniz, Miriam, Pereira, Alessandro Antônio Costa, da Silva, Paulo Henrique Braz, Malaquias, Luiz Cosme Cotta, Coelho, Luiz Felipe Leomil
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal models Animals Antibodies, Bacterial - blood antibody formation antigens Antigens, Bacterial - immunology Applied microbiology Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Bovine serum albumin cystic fibrosis edema enzyme-linked immunosorbent assay functional response Fundamental and applied biological sciences. Psychology histopathology humans immunoglobulin G Immunoglobulin G - blood Inflammation Inflammation - microbiology Inflammation - pathology Lung - microbiology Lung - pathology lungs Male Mice Microbiology Miscellaneous Nanoparticles nose pathogens patients Pseudomonas aeruginosa Pseudomonas Infections - immunology Pseudomonas Infections - prevention & control Serum Albumin, Bovine - administration & dosage Vaccine vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Beschreibung
Zusammenfassung:	Highlights • A nanoparticle associated to P. aeruginosa antigens is proposed as a new vaccine. • The immunized mice showed a significant production of anti P. aeruginosa antibodies. • The immunized mice had a less lung tissue damage induced by live P. aeruginosa.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.08.078