Protective Effect of Leptin and Ghrelin against Toxicity Induced by Amyloid-β Oligomers in a Hypothalamic cell Line

In addition to cognitive decline, Alzheimer's disease (AD) patients also exhibit an unexplained weight loss that correlates with disease progression. In young and middle‐aged AD patients, large amounts of amyloid‐β (Aβ) deposits were observed in the hypothalamus, a brain region involved in the...

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Veröffentlicht in:	Journal of neuroendocrinology 2014-03, Vol.26 (3), p.176-185
Hauptverfasser:	Gomes, S., Martins, I., Fonseca, A. C. R. G., Oliveira, C. R., Resende, R., Pereira, C. M. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - toxicity amyloid-β oligomers Animals Biopolymers - toxicity Calcium - metabolism Cell Line ghrelin Ghrelin - pharmacology hypothalamus Hypothalamus - cytology Hypothalamus - drug effects Hypothalamus - metabolism leptin Leptin - pharmacology Membrane Potential, Mitochondrial Mice mitochondrial dysfunction Peptide Fragments - antagonists & inhibitors Peptide Fragments - toxicity Reactive Oxygen Species - metabolism
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